| FAM86B1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FAM86B1 , family with sequence similarity 86 member B1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616122 GeneCards: FAM86B1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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FAM86B1 is a protein, which in humans is encoded by the FAM86B1 gene. FAM86B1 is an essential gene in humans. [9] The protein contains two domains: FAM86, and AdoMet-MTase.
FAM86B1 homologs are found in most eukaryotes, from mammals to plants such as wild soybean.
FAM86B1 in the human genome is located at 8p23.1, spanning about 12,000 base pairs. FAM86B1 contains 9 exons. [10]
8p23.1 is the location of one of the largest and most common genetic inversions in humans. [11] FAM86B1 is upregulated in inv-8p23.1. [12] In the non-inverted allele 8p23.1, FAM86B1 is on the negative strand. [13] In the allele inv-8p23.1, FAM86B1 is on the positive strand. [14]
In humans, there are 20 alternative splicings of FAM86B1, and 19 mRNA transcripts. In humans, FAM86B1 is expressed ubiquitously, [15] and most strongly in brain tissues and the pituitary gland. [16]
The human FAM86B1 protein contains two domains, FAM86 and AdoMet-MTase, making FAM86B1 a member of these two protein families. [17] The human FAM86B1 gene encodes 13 protein isoforms. FAM86B1 is a non-classically secreted protein, targeted to the peroxisome by a C-terminus signal. [18]
FAM86B1 interacts with ubiquitin-C [19] and FAM86C1. [20]
FAM86B1 homologs are seen in most eukaryotes, but are not found in distant plants, such as green algae. Wild soybean is the most distant species from humans with a FAM86B1 homolog.
FAM86B1 in humans is paralogous with other FAM86 protein-coding genes.
| Gene symbol | Gene location | NCBI gene ID |
|---|---|---|
| EEF2KMT | 16p13.3 | 196483 |
| FAM86B1 | 8p23.1 | 85002 |
| FAM86B2 | 8p23.1 | 653333 |
| FAM86B3 | 8p23.1 | 286042 |
| LOC128966622 | 8p23.1 | 128966622 |
| FAM86C1 | 11q13.4 | 55199 |
| FAM86C2 | 11q13.2 | 645332 |
Alternative splicings of FAM86B1 are associated with decreased relapse in rectal cancer [21] and surviving longer in glioblastoma. [22] In bladder urothelial carcinoma, a differing FAM86B1 expression pattern compared to noncancer controls is associated with surviving longer. [23] In glioma, lower survival rates are associated with downregulation of FAM86B1. [24] Loss of FAM86B1 expression is associated with uterine carcinosarcoma, prostate adenocarcinoma, and bladder urothelial carcinoma. [25]
Severe respiratory syncytial virus bronchiolitis is associated with downregulation of FAM86B1. [26] Enterovirus-71, a positive-sense single-stranded RNA virus, binds to FAM86B1. [27] FAM86B1 is upregulated after exposure to the infection agent of Candida albicans . [28]
FAM86B1 is upregulated after exposure to oS100A4, a potential trigger of inflammation in rheumatoid arthritis. [28] FAM86B1 is downregulated after remote ischemic preconditioning, which inhibits inflammation regulation. [29]
Mitochondrially encoded 12S ribosomal RNA is the SSU rRNA of the mitochondrial ribosome. In humans, 12S is encoded by the MT-RNR1 gene and is 959 nucleotides long. MT-RNR1 is one of the 37 genes contained in animal mitochondria genomes. Their 2 rRNA, 22 tRNA and 13 mRNA genes are very useful in phylogenetic studies, in particular the 12S and 16S rRNAs. The 12S rRNA is the mitochondrial homologue of the prokaryotic 16S and eukaryotic nuclear 18S ribosomal RNAs. Mutations in the MT-RNR1 gene may be associated with hearing loss. The rRNA gene also encodes a peptide MOTS-c, also known as Mitochondrial-derived peptide MOTS-c or Mitochondrial open reading frame of the 12S rRNA-c.
Protein YIF1A is a Yip1 domain family proteins that in humans is encoded by the YIF1A gene.
Family with sequence similarity 167, member A is a protein in humans that is encoded by the FAM167A gene located on chromosome 8. FAM167A and its paralogs are protein encoding genes containing the conserved domain DUF3259, a protein of unknown function. FAM167A has many orthologs in which the domain of unknown function is highly conserved.
Transmembrane protein 151B is a protein that in humans is encoded by the TMEM151B gene.
Uncharacterized protein Chromosome 16 Open Reading Frame 71 is a protein in humans, encoded by the C16orf71 gene. The gene is expressed in epithelial tissue of the respiratory system, adipose tissue, and the testes. Predicted associated biological processes of the gene include regulation of the cell cycle, cell proliferation, apoptosis, and cell differentiation in those tissue types. 1357 bp of the gene are antisense to spliced genes ZNF500 and ANKS3, indicating the possibility of regulated alternate expression.
Uncharacterized protein C12orf60 is a protein that in humans is encoded by the C12orf60 gene. The gene is also known as LOC144608 or MGC47869. The protein lacks transmembrane domains and helices, but it is rich in alpha-helices. It is predicted to localize in the nucleus.
Retrotransposon Gag Like 6 is a protein encoded by the RTL6 gene in humans. RTL6 is a member of the Mart family of genes, which are related to Sushi-like retrotransposons and were derived from fish and amphibians. The RTL6 protein is localized to the nucleus and has a predicted leucine zipper motif that is known to bind nucleic acids in similar proteins, such as LDOC1.
Uncharacterized protein C2orf73 is a protein that in humans is encoded by the C2orf73 gene. The protein is predicted to be localized to the nucleus.
Colon cancer associated transcript 1 is a long non-coding RNA that, in humans, is encoded by the CCAT1 gene.
Proline-rich protein 30 is a protein in humans that is encoded for by the PRR30 gene. PRR30 is a member in the family of Proline-rich proteins characterized by their intrinsic lack of structure. Copy number variations in the PRR30 gene have been associated with an increased risk for neurofibromatosis.
C7orf50 is a gene in humans that encodes a protein known as C7orf50. This gene is ubiquitously expressed in the kidneys, brain, fat, prostate, spleen, among 22 other tissues and demonstrates low tissue specificity. C7orf50 is conserved in chimpanzees, Rhesus monkeys, dogs, cows, mice, rats, and chickens, along with 307 other organisms from mammals to fungi. This protein is predicted to be involved with the import of ribosomal proteins into the nucleus to be assembled into ribosomal subunits as a part of rRNA processing. Additionally, this gene is predicted to be a microRNA (miRNA) protein coding host gene, meaning that it may contain miRNA genes in its introns and/or exons.
ProteinFAM89A is a protein which in humans is encoded by the FAM89A gene. It is also known as chromosome 1 open reading frame 153 (C1orf153). Highest FAM89A gene expression is observed in the placenta and adipose tissue. Though its function is largely unknown, FAM89A is found to be differentially expressed in response to interleukin exposure, and it is implicated in immune responses pathways and various pathologies such as atherosclerosis and glioma cell expression.
FAM237A is a protein coding gene which encodes a protein of the same name. Within Homo sapiens, FAM237A is believed to be primarily expressed within the brain, with moderate heart and lesser testes expression,. FAM237A is hypothesized to act as a specific activator of receptor GPR83.
Transmembrane protein 212 is a protein that in humans is encoded by the TMEM212 gene. The protein consists of 5 transmembrane domains and localizes in the plasma membrane and endoplasmic reticulum. TMEM212 has orthologs in vertebrates but not invertebrates. TMEM212 has been associated with sporadic Parkinson's disease, facial processing, and adiposity in African Americans.
KIAA2013, also known as Q8IYS2 or MGC33867, is a single-pass transmembrane protein encoded by the KIAA2013 gene in humans. The complete function of KIAA2013 has not yet been fully elucidated.
TEKTIP1, also known as tektin-bundle interacting protein 1, is a protein that in humans is encoded by the TEKTIP1 gene.
THAP domain-containing protein 3 (THAP3) is a protein that, in Homo sapiens (humans), is encoded by the THAP3 gene. The THAP3 protein is as known as MGC33488, LOC90326, and THAP domain-containing, apoptosis associated protein 3. This protein contains the Thanatos-associated protein (THAP) domain and a host-cell factor 1C binding motif. These domains allow THAP3 to influence a variety of processes, including transcription and neuronal development. THAP3 is ubiquitously expressed in H. sapiens, though expression is highest in the kidneys.
Chromosome 13 Open Reading Frame 46 is a protein which in humans is encoded by the C13orf46 gene. In humans, C13orf46 is ubiquitously expressed at low levels in tissues, including the lungs, stomach, prostate, spleen, and thymus. This gene encodes eight alternatively spliced mRNA transcript, which produce five different protein isoforms.
C6orf163 is a human protein encoded by the C6orf163 gene.
Zinc Finger Protein 62, also known as "ZNF62," "ZNF755," or "ZET," is a protein that in humans is encoded by the ZFP62 gene. ZFP62 is part of the C2H2 Zinc Finger family of genes.
