Kalirin, also known as Huntingtin-associated protein-interacting protein (HAPIP), protein duo (DUO), or serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, is a protein that in humans is encoded by the KALRN gene. Kalirin was first identified in 1997 as a protein interacting with huntingtin-associated protein 1. Is also known to play an important role in nerve growth and axonal development.
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42.
A-kinase anchor protein 13 is a protein that in humans is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.
Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome number seven in humans and is located on chromosome number thirteen in mice.
The DBL proto-oncogene is a protein that in humans is encoded by the MCF2 gene.
TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.
Oxysterol-binding protein-related protein 5 is a protein that in humans is encoded by the OSBPL5 gene.
Pleckstrin homology domain-containing family A member 5 is a protein that in humans is encoded by the PLEKHA5 gene.
Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.
WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.
Puratrophin-1 is a protein that in humans is encoded by the PLEKHG4 gene.
Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.
Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the PLEKHF2 gene.
FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.
Dock4, also known as DOCK4, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-B subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock4 activates the small G proteins Rac and Rap1.
Dock9, also known as Zizimin1, is a large protein involved in intracellular signalling networks. It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors that function as activators of small G proteins. Dock9 activates the small G protein Cdc42.
Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.
FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.
