FARP1

FARP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H6Y
Identifiers
Aliases	FARP1 , CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs	OMIM: 602654; MGI: 2446173; HomoloGene: 38098; GeneCards: FARP1; OMA:FARP1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q32.2 Start 98,142,562 bp [1] End 98,455,176 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E5 Start 121,272,612 bp [2] End 121,521,156 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla stromal cell of endometrium corpus epididymis ganglionic eminence human kidney ventricular zone epithelium of colon right lobe of liver parotid gland thyroid gland Top expressed in internal carotid artery external carotid artery mandibular prominence molar maxillary prominence hand Gonadal ridge medullary collecting duct vas deferens pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity cytoskeletal protein binding Cellular component cytosol cell projection membrane filopodium extrinsic component of cytoplasmic side of plasma membrane plasma membrane dendritic spine synapse cell junction dendrite neuron projection cytoskeleton cytoplasm Biological process dendrite morphogenesis negative regulation of phosphatase activity multicellular organism development synapse assembly regulation of Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10160 223254 Ensembl ENSG00000152767 ENSMUSG00000025555 UniProt Q9Y4F1 F8VPU2 RefSeq (mRNA) NM_001001715 NM_001286839 NM_005766 NM_134082 RefSeq (protein) NP_001001715 NP_001273768 NP_005757 NP_598843 Location (UCSC) Chr 13: 98.14 – 98.46 Mb Chr 14: 121.27 – 121.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene. ^{[5] [6]}

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[6]

See also

• FARP2
• FERM domain
• RhoGEF domain
• Pleckstrin homology domain

References

1. GRCh38: Ensembl release 89: ENSG00000152767 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025555 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID   9425278.
6. "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

Further reading

• Zhuang B, Su YS, Sockanathan S (February 2009). "FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling". Neuron. 61 (3): 359–72. doi:10.1016/j.neuron.2008.12.022. PMC   2654783 . PMID   19217374.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• FARP1 human gene location in the UCSC Genome Browser .
• FARP1 human gene details in the UCSC Genome Browser .