FARP2

FARP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GYV, 4GZU
Identifiers
Aliases	FARP2 , FIR, FRG, PLEKHC3, FERM, ARH/RhoGEF and pleckstrin domain protein 2
External IDs	OMIM: 617586; MGI: 2385126; HomoloGene: 8877; GeneCards: FARP2; OMA:FARP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,356,285 bp [1] End 241,494,841 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 93,439,801 bp [2] End 93,549,698 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon sural nerve right testis left testis right hemisphere of cerebellum skin of leg skin of abdomen rectum mucosa of sigmoid colon mucosa of transverse colon Top expressed in fossa calvaria primary oocyte zygote retinal pigment epithelium left lobe of liver secondary oocyte epithelium of lens body of femur molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal protein binding guanyl-nucleotide exchange factor activity Cellular component cytosol cytoskeleton cytoplasm Biological process osteoclast differentiation neuron remodeling actin cytoskeleton reorganization regulation of integrin activation podosome assembly cell adhesion Rac protein signal transduction regulation of Rho protein signal transduction semaphorin-plexin signaling pathway hair cycle process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9855 227377 Ensembl ENSG00000006607 ENSMUSG00000034066 UniProt O94887 Q91VS8 RefSeq (mRNA) NM_001282983 NM_001282984 NM_014808 NM_145519 RefSeq (protein) NP_001269912 NP_001269913 NP_055623 NP_663494 Location (UCSC) Chr 2: 241.36 – 241.49 Mb Chr 1: 93.44 – 93.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene. ^{[5] [6] [7]}

Interactions

FARP2 has been shown to interact with PDZK1. ^[8]

See also

• FARP1
• FERM domain
• RhoGEF domain
• Pleckstrin homology domain

References

1. GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
6. Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC   6757789 . PMID   12351724.
7. "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".
8. Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID   14531806.

Further reading

• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID   14531806.
• Miyamoto Y, Yamauchi J, Itoh H (Aug 2003). "Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK". The Journal of Biological Chemistry. 278 (32): 29890–900. doi: 10.1074/jbc.M301559200 . PMID   12771149.
• Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.

External links

• Overview of all the structural information available in the PDB for UniProt : Q91VS8 (FERM, ARHGEF and pleckstrin domain-containing protein 2) at the PDBe-KB .