FARP2

FARP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GYV, 4GZU
Identifiers
Aliases	FARP2 , FIR, FRG, PLEKHC3, FERM, ARH/RhoGEF and pleckstrin domain protein 2
External IDs	OMIM: 617586; MGI: 2385126; HomoloGene: 8877; GeneCards: FARP2; OMA:FARP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,494,841 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,549,698 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; sural nerve; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; skin of leg; ; skin of abdomen; ; rectum; ; mucosa of sigmoid colon; ; mucosa of transverse colon;
	Top expressed in
	fossa; ; calvaria; ; primary oocyte; ; zygote; ; retinal pigment epithelium; ; left lobe of liver; ; secondary oocyte; ; epithelium of lens; ; body of femur; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding ; guanyl-nucleotide exchange factor activity ;
Cellular component	cytosol ; cytoskeleton ; cytoplasm ;
Biological process	osteoclast differentiation ; neuron remodeling ; actin cytoskeleton reorganization ; regulation of integrin activation ; podosome assembly ; cell adhesion ; Rac protein signal transduction ; regulation of Rho protein signal transduction ; semaphorin-plexin signaling pathway ; hair cycle process ;
	Sources:Amigo / QuickGO
Orthologs
	9855
	227377
	ENSG00000006607
	ENSMUSG00000034066
	O94887
	Q91VS8
	NM_001282983 ; NM_001282984 ; NM_014808
	NM_145519
	NP_001269912 ; NP_001269913 ; NP_055623
	NP_663494
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 28, 2024

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.^[5]^[6]^[7]

Interactions

FARP2 has been shown to interact with PDZK1.^[8]

Related Research Articles

<span class="mw-page-title-main">Guanine nucleotide exchange factor</span> Proteins which remove GDP from GTPases

Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42.

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene.

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.

Solute carrier family 22, member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.

PDZK1-interacting protein 1 is a protein that in humans is encoded by the PDZK1IP1 gene.

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene.

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.

Sodium-dependent phosphate transport protein 1 is a protein that in humans is encoded by the SLC17A1 gene.

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

Sodium-dependent phosphate transport protein 2C is a protein that in humans is encoded by the SLC34A3 gene.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.
↑ Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC 6757789 . PMID 12351724.
↑ "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".
↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.

External links

Overview of all the structural information available in the PDB for UniProt : Q91VS8 (FERM, ARHGEF and pleckstrin domain-containing protein 2) at the PDBe-KB .

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.

[pmid12351724-6] Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC 6757789 . PMID 12351724.

[entrez-7] "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".

[pmid14531806-8] Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.

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FARP2

Contents

Interactions

See also

Related Research Articles

References

Further reading

External links