| FBXO31 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | FBXO31 , FBX14, FBXO14, Fbx31, pp2386, MRT45, F-box protein 31 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609102 MGI: 1354708 HomoloGene: 11684 GeneCards: FBXO31 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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F-box only protein 31 is a protein that in humans is encoded by the FBXO31 gene. [5]
Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [6] [5]
F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. the F-box protein FBXO31, a candidate tumor suppressor encoded in 16q24.3 for which there is loss of heterozygosity in various solid tumors, is responsible for promoting MDM2 degradation. Following genotoxic stress, FBXO31 is phosphorylated by the DNA damage serine/threonine kinase ATM, resulting in increased levels of FBXO31. FBXO31 then interacts with and directs the degradation of MDM2, which is dependent on phosphorylation of MDM2 by ATM. FBXO31-mediated loss of MDM2 leads to elevated levels of p53, resulting in growth arrest. In cells depleted of FBXO31, MDM2 is not degraded and p53 levels do not increase following genotoxic stress. Thus, FBXO31 is essential for the classic robust increase in p53 levels following DNA damage. [7]
Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene.
F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene. Mutations in FBXO7 have been associated with Parkinson's disease.
Spermatid perinuclear RNA-binding protein is a protein that in humans is encoded by the STRBP gene.
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.
Deubiquitinating protein VCIP135 is a protein that in humans is encoded by the VCPIP1 gene.
Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.
Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.
Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.
Beta-taxilin is a protein that in humans is encoded by the TXLNB gene.
Stannin is a protein that in humans is encoded by the SNN gene.
Myopalladin is a protein that in humans is encoded by the MYPN gene. Myopalladin is a muscle protein responsible for tethering proteins at the Z-disc and for communicating between the sarcomere and the nucleus in cardiac and skeletal muscle
Myopodin protein, also called Synaptopodin-2 is a protein that in humans is encoded by the SYNPO2 gene. Myopodin is expressed in cardiac, smooth muscle and skeletal muscle, and localizes to Z-disc structures.
High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene.
Hippocalcin like 4, also known as HPCAL4, is a human gene.
Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene.
Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.
Spartan (SPRTN) is a protein that in humans is encoded by the SPRTN gene. It is involved in DNA repair. Ruijs-Aalfs syndrome is an autosomal recessive genetic disorder. Characteristics of this disorder are features of premature aging, chromosome instability and development of hepatocellular carcinoma. Ruijs-Aalfs syndrome arises as a result of mutations in the SPRTN gene that encodes a metalloproteinase employed in the repair of protein-linked DNA breaks.
Secretory carrier-associated membrane protein 5 is a protein that in humans is encoded by the SCAMP5 gene.
Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.
F-box protein 40 is a protein that in humans is encoded by the FBXO40 gene. Fbxo40 induces ubiqitination of IRS1, thus limiting activity of IGF1 signaling.
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