FZR1

Last updated

FZR1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FZR1 , CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDs OMIM: 603619; MGI: 1926790; HomoloGene: 9444; GeneCards: FZR1; OMA:FZR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136197
NM_001136198
NM_016263

NM_019757

RefSeq (protein)

NP_001129669
NP_001129670
NP_057347

NP_062731

Location (UCSC) Chr 19: 3.51 – 3.54 Mb Chr 10: 81.2 – 81.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene. [5] [6] [7] [8]

Contents

Interactions

FZR1 has been shown to interact with CDC27 [9] [10] and FBXO5. [11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105325 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020235 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (1998-11-05). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. Bibcode:1998CBio....8.1207K. doi: 10.1016/S0960-9822(07)00510-6 . ISSN   0960-9822. PMID   9811605. S2CID   17181162.
  6. Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Molecular Cell. 2 (2): 163–71. doi: 10.1016/S1097-2765(00)80126-4 . PMID   9734353.
  7. Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (October 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Molecular and Cellular Biology. 20 (20): 7613–23. doi:10.1128/MCB.20.20.7613-7623.2000. PMC   86321 . PMID   11003657.
  8. "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".
  9. Zhou Y, Ching YP, Ng RW, Jin DY (September 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC   1223613 . PMID   12797865.
  10. Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (November 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. Bibcode:1998CBio....8.1207K. doi: 10.1016/S0960-9822(07)00510-6 . PMID   9811605. S2CID   17181162.
  11. Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID   11988738. S2CID   25403043.

Further reading