Four Thieves Vinegar Collective

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Four Thieves Vinegar Collective
Named after Four thieves vinegar
Formation2015;9 years ago (2015)
Founder Michael Laufer
Legal statusActive
Purpose Biohacking
ProductsEpiPencil, Apothecary MicroLab
Website fourthievesvinegar.org

The Four Thieves Vinegar Collective is an anarchist biohacking group founded in 2015 by Michael Laufer. They have published instructions for the "EpiPencil", an epinephrine autoinjector, and the "Apothecary MicroLab", a do-it-yourself (DIY) device intended to make a variety of medications, most notably pyrimethamine (Daraprim). They have been criticized by the medical community for causing potential harm to patients with the DIY instructions, but Laufer claims to defend people's right to attempt their own medical treatment.

Contents

Members

Four Thieves' membership is generally composed of technically-trained people, but does not include medical professionals. [1]

Views

Laufer has compared his work to that of Women on Waves, a group that provides abortion medication to women in areas where abortion is illegal. [2] His motivation in founding the group is to provide medication to people when it is too expensive for them to afford, is illegal to acquire, or is unavailable due to it treating an orphan disease. He believes that providing lifesaving medication to any that need it justifies violating intellectual property rights of pharmaceutical companies, and supports cognitive liberty. [1]

History

Laufer, who is trained in mathematics, decided to form the group in 2008 during a graduate school trip to El Salvador. While visiting a local medical clinic he learned that despite the existence of many clandestine chemistry labs producing methamphetamine and MDMA, the clinic was out of oral contraceptives. He investigated the possibility of DIY pharmaceuticals which culminated in the founding of Four Thieves in 2015. [3] He took the name from four thieves vinegar, a legendary plague cure. [4]

Four Thieves had formerly partnered with Chematica to develop recipes for the group's medication, [2] but this ended and they lost access to information and software they had been given after pharmaceutical company Merck bought the startup. [1]

EpiPencil

In 2016, after the price for an EpiPen was raised from $57 to $318 by its manufacturer Mylan, Four Thieves released instructions for how to build an "EpiPencil", a homemade epinephrine autoinjector that can be built for $30. [5] It is made from three off-the-shelf parts. [6] It has been criticized for potential danger. [7] Theresa Eisenman, a spokeswoman for the United States Food and Drug Administration, stated that using such a device is a "potentially dangerous practice". [8] The device is not known to have actually been used. [4]

Apothecary MicroLab

Four Thieves has released instructions for building an "Apothecary MicroLab", a DIY device claimed to be able to synthesize a variety of medications. The group released instructions for manufacturing pyrimethamine (Daraprim) from acetonitrile, ethyl bromide, and dicyandiamide with it. [3] [2] Laufer claims that it can also be used to make naloxone, cabotegravir, mifepristone, and misoprostol. [1] Jeremiah Johnson, a researcher at the Massachusetts Institute of Technology, has stated that using it would be very dangerous as it could create the wrong drug or the wrong dose. [3] Eric von Hippel, an economist at MIT who supports DIY medication, has stated that the design could create chemical byproducts as well as or instead of the intended medication. [1]

Laufer claims that they have successfully synthesized cabotegravir, an experimental new integrase inhibitor, and asked heroin dealers to cut their product with it in order to help lower the rates of HIV infection among heroin users. [1]

Abortion

In 2022, Four Thieves released detailed instructions for how to make an abortion pill, [9] and subsequently distributed business cards at a hacker convention in Queens, New York that were labeled "This Card is an Abortion" and had three doses of misoprostol embedded in them. [10]

Reception

Jose Gomez-Marquez, who is researching pharmaceuticals at MIT, has stated his belief that the group is more about publicity than medication, and is concerned about the danger of unvetted information being published. [3] Vinay Prasad, a professor of medicine at Oregon Health & Science University, believes that DIY medication is "foolhardy". [4]

Jo Zayner, another biohacker, believes that the group's work is more symbolic than anything else. [4]

Chemist Derek Lowe described the Vice magazine article on the collective as "largely bullshit". [11] He noted that they had synthesized known substances rather than producing new ones. [11] He also pointed out that their proposal to combat Hepatitis C could accidentally cause treatment-resistant strains of Hepatitis C. [11]

Patricia Zettler, a former attorney at the FDA, believes that Four Thieves' work is legal because they are only providing information rather than drugs themselves. [4]

See also

Related Research Articles

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Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about a medical abortion during pregnancy and manage early miscarriage. This combination is 97% effective during the first 63 days of pregnancy. It is also effective in the second trimester of pregnancy. It is taken by mouth.

An epinephrine autoinjector is a medical device for injecting a measured dose or doses of epinephrine (adrenaline) by means of autoinjector technology. It is most often used for the treatment of anaphylaxis. The first epinephrine autoinjector was brought to market in 1983.

<span class="mw-page-title-main">Misoprostol</span> Medication to induce abortion and treat ulcers

Misoprostol is a synthetic prostaglandin medication used to prevent and treat stomach and duodenal ulcers, induce labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. It is taken by mouth when used to prevent gastric ulcers in people taking nonsteroidal anti-inflammatory drugs (NSAID). For abortions it is used by itself or in conjunction with mifepristone or methotrexate. By itself, effectiveness for abortion is between 66% and 90%. For labor induction or abortion, it is taken by mouth, dissolved in the mouth, or placed in the vagina. For postpartum bleeding it may also be used rectally.

Self-medication, sometime called do-it-yourself (DIY) medicine, is a human behavior in which an individual uses a substance or any exogenous influence to self-administer treatment for physical or psychological conditions, for example headaches or fatigue.

<span class="mw-page-title-main">Self-induced abortion</span> Abortion performed by a pregnant person themselves outside the recognized medical system

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<span class="mw-page-title-main">King Pharmaceuticals</span> American pharmaceutical company

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An advanced emergency medical technician is a provider of emergency medical services in the United States. A transition to this level of training from the emergency medical technician-intermediate, which have somewhat less training, began in 2013 and has been implemented by most states. AEMTs are not intended to deliver definitive medical care in most cases, but rather to augment prehospital critical care and provide rapid on-scene treatment. AEMTs are usually employed in ambulance services, working in conjunction with EMTs and paramedics; however they are also commonly found in fire departments and law enforcement agencies as non-transporting first responders. Ambulances operating at the AEMT level of care are commonplace in rural areas, and occasionally found in larger cities as part of a tiered-response system, but are overall much less common than EMT- and paramedic-level ambulances. The AEMT provides a low-cost, high-benefit option to provide advanced-level care when the paramedic level of care is not feasible. The AEMT is authorized to provide limited advanced life support, which is beyond the scope of an EMT.

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A medical abortion, also known as medication abortion or non-surgical abortion, occurs when drugs (medication) are used to bring about an abortion. Medical abortions are an alternative to surgical abortions such as vacuum aspiration or dilation and curettage. Medical abortions are more common than surgical abortions in most places around the world.

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<span class="mw-page-title-main">Phineas Fisher</span> Hacktivist

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<span class="mw-page-title-main">Aid Access</span> Abortion services provider

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<span class="mw-page-title-main">Rebecca Gomperts</span> Dutch physician and artist, founder of Women on Waves

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Michael Laufer is the de facto leader of the open-source anarchist biohacking network, Four Thieves Vinegar Collective. Laufer is notable for creating the EpiPencil, an open source alternative to the Epipen.

References

  1. 1 2 3 4 5 6 Oberhaus, Daniel (July 26, 2018). "Meet the Anarchists Making Their Own Medicine". Vice . Retrieved July 31, 2018.
  2. 1 2 3 Rosenblatt, Seth (July 25, 2016). "Hacker targets Big Pharma with homebrew meds". The Parallax. Archived from the original on August 1, 2018. Retrieved August 1, 2018.
  3. 1 2 3 4 Brown, Kristen V. (August 2, 2017). "A DIY Pharmaceutical Revolution Is Coming—If It Doesn't Kill Us First". Gizmodo . Retrieved July 31, 2018.
  4. 1 2 3 4 5 Piller, Charles (October 13, 2017). "An Anarchist Is Teaching Patients to Make Their Own Medications". Scientific American . Retrieved July 31, 2018.
  5. Condliffe, Jamie (September 20, 2016). "It Costs $30 to Make a DIY EpiPen, and Here's the Proof". MIT Technology Review . Retrieved July 31, 2018.
  6. Laufer, Mixæl (September 19, 2016). "Introducing the EpiPencil". Four Thieves Vinegar Collective. Archived from the original on August 14, 2018.
  7. Weill, Kelly (April 13, 2017) [September 22, 2016]. "Please Do Not Hack Your Own EpiPen". The Daily Beast . Retrieved July 31, 2018.
  8. Leonard, Kimberly (September 23, 2016). "EpiPen Alternative? Meet the $30, DIY EpiPencil". U.S. News & World Report . Retrieved August 1, 2018.
  9. Koebler, Jason (May 3, 2022). "Anarchist Collective Shares Instructions to Make DIY Abortion Pills". Vice. Retrieved May 10, 2022.
  10. Franceschi-Bicchierai, Lorenzo (July 22, 2022). "DIY Collective Embeds Abortion Pill Onto Business Cards, Distributes Them At Hacker Conference". Vice. Retrieved July 28, 2022.
  11. 1 2 3 Lowe, Derek (July 30, 2018). "Anarchist Drugs For All. Yeahboy". Science . Retrieved December 1, 2018.