GAS2

GAS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5R
Identifiers
Aliases	GAS2 , growth arrest specific 2, GAS-2
External IDs	OMIM: 602835 MGI: 95657 HomoloGene: 31301 GeneCards: GAS2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	22,813,001 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	51,644,723 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; liver; ; sural nerve; ; right lobe of liver; ; islet of Langerhans; ; Achilles tendon; ; spinal ganglia; ; body of pancreas; ; hair follicle; ; metanephric glomerulus;
	Top expressed in
	stria vascularis; ; proximal tubule; ; utricle; ; kidney; ; hand; ; cochlea; ; saccule; ; left lobe of liver; ; spermatocyte; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding ; actin binding ;
Cellular component	cytoskeleton ; cytosol ; actin filament ; membrane ; cytoplasm ;
Biological process	cell cycle ; regulation of cell shape ; apoptotic process ; initiation of primordial ovarian follicle growth ; antral ovarian follicle growth ; regulation of Notch signaling pathway ; ovulation ; basement membrane organization ; microtubule cytoskeleton organization ; actin cytoskeleton organization ;
	Sources:Amigo / QuickGO
Orthologs
	2620
	14453
	ENSG00000148935
	ENSMUSG00000030498
	O43903
	P11862
NM_001143830 ; NM_005256 ; NM_177553 ; NM_001351224 ; NM_001391933 ;
	NM_001391934 ; NM_001391935 ; NM_001391936 ; NM_001391937
	NM_008087 ; NM_001330607 ; NM_001330608
	NP_001137302 ; NP_005247 ; NP_808221 ; NP_001338153
	NP_001317536 ; NP_001317537 ; NP_032113
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.^[5]^[6]

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]

Related Research Articles

The Fas receptor, also known as Fas, FasR, apoptosis antigen 1, cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene. Fas was first identified using a monoclonal antibody generated by immunizing mice with the FS-7 cell line. Thus, the name Fas is derived from FS-7-associated surface antigen.

Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. CASP2 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.

Baculoviral IAP repeat-containing protein3 is a protein that in humans is encoded by the BIRC3 gene.

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

Calpain-2 catalytic subunit is a protein that in humans is encoded by the CAPN2 gene.

Calpastatin is a protein that in humans is encoded by the CAST gene.

MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene.

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene.

GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene.

E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene.

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.

Caspase activity and apoptosis inhibitor 1 is a protein that in humans is encoded by the CAAP1 gene.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.
1 2 "Entrez Gene: GAS2 growth arrest-specific 2".

Olson RE, Morello JA, Kieff ED (1975). "Antibiotic treatment of oral anaerobic infections". Journal of Oral Surgery. 33 (8): 619–21. PMID 1056466.
Brancolini C, Bottega S, Schneider C (1992). "Gas2, a growth arrest-specific protein, is a component of the microfilament network system". J. Cell Biol. 117 (6): 1251–61. doi:10.1083/jcb.117.6.1251. PMC 2289493 . PMID 1607387.
Schneider C, King RM, Philipson L (1988). "Genes specifically expressed at growth arrest of mammalian cells". Cell. 54 (6): 787–93. doi:10.1016/S0092-8674(88)91065-3. PMID 3409319. S2CID 37196421.
Sgorbissa A, Benetti R, Marzinotto S, et al. (2000). "Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis". J. Cell Sci. 112 (23): 4475–82. doi:10.1242/jcs.112.23.4475. PMID 10564664.
Benetti R, Del Sal G, Monte M, et al. (2001). "The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis". EMBO J. 20 (11): 2702–14. doi:10.1093/emboj/20.11.2702. PMC 125501 . PMID 11387205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tsutsumi S, Kamata N, Vokes TJ, et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089 . PMID 15124103.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Benetti R, Copetti T, Dell'Orso S, et al. (2005). "The calpain system is involved in the constitutive regulation of beta-catenin signaling functions". J. Biol. Chem. 280 (23): 22070–80. doi: 10.1074/jbc.M501810200 . PMID 15817486.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148935 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030498 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9521882-5] Collavin L, Buzzai M, Saccone S, Bernard L, Federico C, DellaValle G, Brancolini C, Schneider C (Jun 1998). "cDNA characterization and chromosome mapping of the human GAS2 gene". Genomics. 48 (2): 265–9. doi:10.1006/geno.1997.5172. PMID 9521882.

[entrez-6] 1 2 "Entrez Gene: GAS2 growth arrest-specific 2".

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[2]

[3]

[4]

[5]

[6]

GAS2

Related Research Articles

References

Further reading