GRAM domain-containing 2B

Last updated
GRAMD2B
Identifiers
Aliases GRAMD2B , NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDs MGI: 1914815 HomoloGene: 32570 GeneCards: GRAMD2B
Gene location (Human)
Ideogram human chromosome 5.svg
Chr. Chromosome 5 (human) [1]
Human chromosome 5 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 5q23.2Start126,360,132 bp [1]
End126,496,494 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

65983

107022

Ensembl

ENSG00000155324

ENSMUSG00000001700

UniProt

Q96HH9

Q6PEM6

RefSeq (mRNA)

NM_026240
NM_001360917

RefSeq (protein)

NP_080516
NP_001347846

Location (UCSC) Chr 5: 126.36 – 126.5 Mb Chr 18: 56.4 – 56.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene. [5] [6]

GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family. [7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum. [8] [7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.

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Gram domain containing 1a protein-coding gene in the species Homo sapiens

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GRAMD1C protein-coding gene in the species Homo sapiens

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Gram domain-containing 2A

GRAM domain-containing 2A protein is a protein encoded by the GRAMD2A gene. Like GRAMD2B, the protein consists of a GRAM domain and a transmembrane domain that anchors it to the endoplasmic reticulum.

VAD1 analog of StAR-related lipid transfer (VASt) is a steroidogenic acute regulatory protein‐related lipid transfer (StART)-like lipid-binding domain first identified in the vad1 protein in Arabidopsis thaliana. Proteins containing these domains are found in eukaryotes and usually contain another lipid-binding domain, typically the GRAM domain and sometimes the C2 domain in plants and the integral peroxisomal membrane peroxin Pex24p domain in oomycetes.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000155324 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001700 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]" . Retrieved March 7, 2020.
  6. ↑ "UniProtKB - Q96HH9 (GRM2B_HUMAN)" . Retrieved March 7, 2020.
  7. 1 2 Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC   5823543 . PMID   29469807.
  8. ↑ "RecName: Full=GRAM domain-containing protein 2A)" . Retrieved March 7, 2020.
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