GUCA1B

Last updated
GUCA1B
Identifiers
Aliases GUCA1B , GCAP2, GUCA2, RP48, guanylate cyclase activator 1B, GCAP 2
External IDs OMIM: 602275; MGI: 1194489; HomoloGene: 1586; GeneCards: GUCA1B; OMA:GUCA1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002098

NM_146079

RefSeq (protein)

NP_002089

NP_666191

Location (UCSC) Chr 6: 42.18 – 42.19 Mb Chr 17: 47.7 – 47.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene. [5] [6] Alternative names: [7]

Contents

Biological Role

Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation. [8] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase. [8] This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112599 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023979 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, et al. (February 1997). "The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1)". Genomics. 39 (3): 312–22. doi: 10.1006/geno.1996.4513 . PMID   9119368.
  6. "Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina)".
  7. "GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein". www.uniprot.org. Retrieved 2017-10-09.
  8. 1 2 Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K (April 1994). "Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 4014–8. Bibcode:1994PNAS...91.4014G. doi: 10.1073/pnas.91.9.4014 . PMC   43713 . PMID   7909609.

Further reading