Gestation

Last updated
Drawing of a fetus in utero. Feminology; a guide for womankind, giving in detail instructions as to motherhood, maidenhood, and the nursery (1902) (14761381441).jpg
Drawing of a fetus in utero.

Gestation is the period of development during the carrying of an embryo, and later fetus, inside viviparous animals (the embryo develops within the parent). [1] It is typical for mammals, but also occurs for some non-mammals. Mammals during pregnancy can have one or more gestations at the same time, for example in a multiple birth. [2]

Contents

The time interval of a gestation is called the gestation period . In obstetrics, gestational age refers to the time since the onset of the last menses, which on average is fertilization age plus two weeks. [3]

Mammals

In mammals, pregnancy begins when a zygote (fertilized ovum) implants in the female's uterus and ends once the fetus leaves the uterus during labor or an abortion (whether induced or spontaneous).

Humans

Timeline of human fertilization Human Fertilization.png
Timeline of human fertilization

In humans, pregnancy can be defined clinically, biochemically or biologically. Clinically, pregnancy starts from first day of the mother's last period. [4] Biochemically, pregnancy starts when a woman's human chorionic gonadotropin (hCG) levels rise above 25 mIU/mL. [5] Biologically, pregnancy starts at implantation of the fertilized egg.

Human pregnancy can be divided into three trimesters, each approximately three months long: the first, second, and third trimester. The first trimester is from the last menstrual period through the 13th week, the second trimester is 14th–28/29th week, and the third trimester is 29/30th–42nd week. [6] Birth normally occurs at a gestational age of about 40 weeks, though it is common for births to occur from 37 to 42 weeks. [6] Labor occurring prior to 37 weeks gestation is considered preterm labor and can result from multiple factors, including previous preterm deliveries. [7] [8]

Prenatal care is important for the maintenance of a healthy pregnancy and surveillance of related complications. In high-income countries, prenatal care typically involves monthly visits during the first two trimesters, with an increasing number of visits closer to delivery. At these visits, healthcare providers will evaluate a variety of parental and fetal metrics, including fetal growth and heart rate, birth defects, maternal blood pressure, among others. [9]

After birth, health care providers will measure the baby's weight, vital signs, reflexes, head circumference, muscle tone, and posture to help determine the gestational age. [10]

Various factors can influence the duration of gestation, including diseases in pregnancy and adequate prenatal care. [11] The rates of morbidity and pre-existing diseases that predispose mothers to life-threatening, pregnancy-related complications in the United States are increasing. [12] Inaccessibility of prenatal care may partially explain this ongoing disparity. [12] [13]

Placental mammals

During gestation in placental mammals there is a gradual physiological increase in senescence in the maternal decidua (the specialized layer of endometrium that forms the base of the placental bed) and in placental cells. [14] This increase in senescence is associated with a gradual physiological increase in DNA damage during gestation. A positive correlation between the gestation period and maximum lifespan was observed across 740 mammalian species. [14] It was postulated that the rates of DNA damage and senescence may impact the gestation period as well as lifespan. [14]

Non-mammals

Pregnant scorpion Pregnant scorpion.jpg
Pregnant scorpion

In viviparous animals, the embryo develops inside the body of the mother, as opposed to outside in an egg (oviparity). The mother then gives live birth. The less developed form of viviparity is called ovoviviparity, in which the mother carries embryos inside eggs. Most vipers exhibit ovoviviparity. [15] The more developed form of viviparity is called placental viviparity; mammals are the best example, but it has also evolved independently in other animals, such as in scorpions, some sharks, and in velvet worms. [16] [17] [18] Viviparous offspring live independently and require an external food supply from birth. Certain lizards also employ this method such as the genera Tiliqua and Corucia. [19] [20] The placenta is attached directly to the mother in these lizards which is called viviparous matrotrophy. [21]

Ovoviviparous animals develop within eggs that remain within the mother's body up until they hatch or are about to hatch. It is similar to viviparity in that the embryo develops within the mother's body. Unlike the embryos of viviparous species, ovoviviparous embryos are nourished by the egg yolk rather than by the mother's body. [22] However, the mother's body does provide gas exchange. [23] The young of ovoviviparous amphibians are sometimes born as larvae, and undergo metamorphosis outside the body of the mother. [24]

The fish family Syngnathidae has the unique characteristic whereby females lay their eggs in a brood pouch on the male's chest, and the male incubates the eggs. [25] Fertilization may take place in the pouch or before implantation in the water. Included in Syngnathidae are seahorses, the pipefish, and the weedy and leafy sea dragons. [26] Syngnathidae is the only family in the animal kingdom to which the term "male pregnancy" has been applied. [27]

See also

Related Research Articles

<span class="mw-page-title-main">Multiple birth</span> End of a multiple pregnancy where two or more offspring are born

A multiple birth is the culmination of one multiple pregnancy, wherein the mother gives birth to two or more babies. A term most applicable to vertebrate species, multiple births occur in most kinds of mammals, with varying frequencies. Such births are often named according to the number of offspring, as in twins and triplets. In non-humans, the whole group may also be referred to as a litter, and multiple births may be more common than single births. Multiple births in humans are the exception and can be exceptionally rare in the largest mammals.

<span class="mw-page-title-main">Birth</span> Process of bearing offspring

Birth is the act or process of bearing or bringing forth offspring, also referred to in technical contexts as parturition. In mammals, the process is initiated by hormones which cause the muscular walls of the uterus to contract, expelling the fetus at a developmental stage when it is ready to feed and breathe.

<span class="mw-page-title-main">Intrauterine growth restriction</span> Medical condition

Intrauterine growth restriction (IUGR), or fetal growth restriction, is the poor growth of a fetus while in the womb during pregnancy. IUGR is defined by clinical features of malnutrition and evidence of reduced growth regardless of an infant's birth weight percentile. The causes of IUGR are broad and may involve maternal, fetal, or placental complications.

<span class="mw-page-title-main">Viviparity</span> Development of the embryo inside the mother

In animals, viviparity is development of the embryo inside the body of the mother, with the maternal circulation providing for the metabolic needs of the embryo's development, until the mother gives birth to a fully or partially developed juvenile that is at least metabolically independent. This is opposed to oviparity, where the embryos develop independently outside the mother in eggs until they are developed enough to break out as hatchlings; and ovoviviparity, where the embryos are developed in eggs that remain carried inside the mother's body until the hatchlings emerge from the mother as juveniles, similar to a live birth.

<span class="mw-page-title-main">Ovoviviparity</span> Gestation type

Ovoviviparity, ovovivipary, ovivipary, or aplacental viviparity is a term used as a "bridging" form of reproduction between egg-laying oviparous and live-bearing viviparous reproduction. Ovoviviparous animals possess embryos that develop inside eggs that remain in the mother's body until they are ready to hatch.

<span class="mw-page-title-main">Preterm birth</span> Birth at less than a specified gestational age

Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 28 and 32 weeks, early preterm birth occurs between 32 and 34 weeks, late preterm birth is between 34 and 36 weeks' gestation. These babies are also known as premature babies or colloquially preemies or premmies. Symptoms of preterm labor include uterine contractions which occur more often than every ten minutes and/or the leaking of fluid from the vagina before 37 weeks. Premature infants are at greater risk for cerebral palsy, delays in development, hearing problems and problems with their vision. The earlier a baby is born, the greater these risks will be.

<span class="mw-page-title-main">Chorionic villus sampling</span> Type of prenatal diagnosis done to determine chromosomal or genetic disorders in the fetus

Chorionic villus sampling (CVS), sometimes called "chorionic villous sampling", is a form of prenatal diagnosis done to determine chromosomal or genetic disorders in the fetus. It entails sampling of the chorionic villus and testing it for chromosomal abnormalities, usually with FISH or PCR. CVS usually takes place at 10–12 weeks' gestation, earlier than amniocentesis or percutaneous umbilical cord blood sampling. It is the preferred technique before 15 weeks.

In obstetrics, gestational age is a measure of the age of a pregnancy taken from the beginning of the woman's last menstrual period (LMP), or the corresponding age of the gestation as estimated by a more accurate method, if available. Such methods include adding 14 days to a known duration since fertilization, or by obstetric ultrasonography. The popularity of using this measure of pregnancy is largely due to convenience: menstruation is usually noticed, while there is generally no convenient way to discern when fertilization or implantation occurred.

<span class="mw-page-title-main">Pregnancy</span> Time of offspring development in mothers body

Pregnancy is the time during which one or more offspring develops (gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins.

<span class="mw-page-title-main">Oviparity</span> Animals that lay their eggs, with little or no other embryonic development within the mother

Oviparous animals are animals that reproduce by depositing fertilized zygotes outside the body in metabolically independent incubation organs known as eggs, which nurture the embryo into moving offsprings known as hatchlings with little or no embryonic development within the mother. This is the reproductive method used by most animal species, as opposed to viviparous animals that develop the embryos internally and metabolically dependent on the maternal circulation, until the mother gives birth to live juveniles.

Prenatal development involves the development of the embryo and of the fetus during a viviparous animal's gestation. Prenatal development starts with fertilization, in the germinal stage of embryonic development, and continues in fetal development until birth.

<span class="mw-page-title-main">Complications of pregnancy</span> Medical condition

Complications of pregnancy are health problems that are related to, or arise during pregnancy. Complications that occur primarily during childbirth are termed obstetric labor complications, and problems that occur primarily after childbirth are termed puerperal disorders. While some complications improve or are fully resolved after pregnancy, some may lead to lasting effects, morbidity, or in the most severe cases, maternal or fetal mortality.

<span class="mw-page-title-main">Placentation</span> Formation and structure of the placenta

Placentation is the formation, type and structure, or arrangement of the placenta. The function of placentation is to transfer nutrients, respiratory gases, and water from maternal tissue to a growing embryo, and in some instances to remove waste from the embryo. Placentation is best known in live-bearing mammals (Theria), but also occurs in some fish, reptiles, amphibians, a diversity of invertebrates, and flowering plants. In vertebrates, placentas have evolved more than 100 times independently, with the majority of these instances occurring in squamate reptiles.

<span class="mw-page-title-main">Velamentous cord insertion</span> Velamentous placenta

Velamentous cord insertion is a complication of pregnancy where the umbilical cord is inserted in the fetal membranes. It is a major cause of antepartum hemorrhage that leads to loss of fetal blood and associated with high perinatal mortality. In normal pregnancies, the umbilical cord inserts into the middle of the placental mass and is completely encased by the amniotic sac. The vessels are hence normally protected by Wharton's jelly, which prevents rupture during pregnancy and labor. In velamentous cord insertion, the vessels of the umbilical cord are improperly inserted in the chorioamniotic membrane, and hence the vessels traverse between the amnion and the chorion towards the placenta. Without Wharton's jelly protecting the vessels, the exposed vessels are susceptible to compression and rupture.

A fetus or foetus is the unborn mammalian offspring that develops from an embryo. Following the embryonic stage, the fetal stage of development takes place. Prenatal development is a continuum, with no clear defining feature distinguishing an embryo from a fetus. However, in general a fetus is characterized by the presence of all the major body organs, though they will not yet be fully developed and functional, and some may not yet be situated in their final anatomical location.

<span class="mw-page-title-main">Placental disease</span> Medical condition

A placental disease is any disease, disorder, or pathology of the placenta.

<span class="mw-page-title-main">Prenatal nutrition</span>

Prenatal nutrition addresses nutrient recommendations before and during pregnancy. Nutrition and weight management before and during pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy development since infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.

<span class="mw-page-title-main">Pregnancy in fish</span>

Pregnancy has been traditionally defined as the period of time eggs are incubated in the body after the egg-sperm union. Although the term often refers to placental mammals, it has also been used in the titles of many international, peer-reviewed, scientific articles on fish, e.g. Consistent with this definition, there are several modes of reproduction in fish, providing different amounts of parental care. In ovoviviparity, there is internal fertilization and the young are born live but there is no placental connection or significant trophic (feeding) interaction; the mother's body maintains gas exchange but the unborn young are nourished by egg yolk. There are two types of viviparity in fish. In histotrophic viviparity, the zygotes develop in the female's oviducts, but she provides no direct nutrition; the embryos survive by eating her eggs or their unborn siblings. In hemotrophic viviparity, the zygotes are retained within the female and are provided with nutrients by her, often through some form of placenta.

<span class="mw-page-title-main">Modes of reproduction</span>

Animals make use of a variety of modes of reproduction to produce their young. Traditionally this variety was classified into three modes, oviparity, viviparity, and ovoviviparity.

Vertebrate maternal behavior is a form of parental care that is specifically given to young animals by their mother in order to ensure the survival of the young. Parental care is a form of altruism, which means that the behaviors involved often require a sacrifice that could put their own survival at risk. This encompasses behaviors that aid in the evolutionary success of the offspring and parental investment, which is a measure of expenditure exerted by the parent in an attempt to provide evolutionary benefits to the offspring. Therefore, it is a measure of the benefits versus costs of engaging in the parental behaviors. Behaviors commonly exhibited by the maternal parent include feeding, either by lactating or gathering food, grooming young, and keeping the young warm. Another important aspect of parental care is whether the care is provided to the offspring by each parent in a relatively equal manner, or whether it is provided predominantly or entirely by one parent. There are several species that exhibit biparental care, where behaviors and/or investment in the offspring is divided equally amongst the parents. This parenting strategy is common in birds. However, even in species who exhibit biparental care, the maternal role is essential since the females are responsible for the incubation and/or delivery of the young.

References

  1. Mckay RJ, Lucey JF (June 1964). "NEONATOLOGY". The New England Journal of Medicine. 270 (23): 1231–6 CONTD. doi:10.1056/NEJM196406042702306. PMID   14132827.
  2. Keith L, Oleszczuk JJ (January 1999). "Iatrogenic multiple birth, multiple pregnancy and assisted reproductive technologies". International Journal of Gynaecology and Obstetrics. 64 (1): 11–25. doi:10.1016/S0020-7292(98)00230-6. PMID   10190665. S2CID   31814692.
  3. Liao JB, Buhimschi CS, Norwitz ER (June 2005). "Normal labor: mechanism and duration". Obstetrics and Gynecology Clinics of North America. 32 (2): 145–64, vii. doi:10.1016/j.ogc.2005.01.001. PMID   15899352.
  4. "You and your baby at 0-8 weeks pregnant". NHS 111 Wales. NHS Wales. 26 April 2018. Retrieved 24 December 2022.
  5. "What is HCG?". American Pregnancy Association. 2020-04-26. Retrieved 2021-09-13.
  6. 1 2 "How Your Baby Grows During Pregnancy" (PDF). American College of Obstetricians and Gynecologists.
  7. Griggs KM, Hrelic DA, Williams N, McEwen-Campbell M, Cypher R (November 2020). "Preterm Labor and Birth: A Clinical Review". MCN: The American Journal of Maternal/Child Nursing. 45 (6): 328–337. doi:10.1097/NMC.0000000000000656. PMID   33074911. S2CID   224813648.
  8. "Preterm Labor and Birth". www.acog.org. Retrieved 2021-09-13.
  9. Helton MR (March 1997). "Prenatal care". Primary Care. 24 (1): 135–46. doi:10.1016/S0095-4543(22)00091-4. PMID   9016732. S2CID   36322807.
  10. "Gestational age: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2021-09-13.
  11. Coley SL, Aronson RE (September 2013). "Exploring Birth Outcome Disparities and the Impact of Prenatal Care Utilization Among North Carolina Teen Mothers". Women's Health Issues. 23 (5): e287–e294. doi:10.1016/j.whi.2013.06.004. PMID   23993476.
  12. 1 2 Gadson, Alexis; Akpovi, Eloho; Mehta, Pooja K. (2017-08-01). "Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome". Seminars in Perinatology. 41 (5): 308–317. doi:10.1053/j.semperi.2017.04.008. ISSN   0146-0005. PMID   28625554.
  13. Gadson A, Akpovi E, Mehta PK (August 2017). "Exploring the social determinants of racial/ethnic disparities in prenatal care utilization and maternal outcome". Seminars in Perinatology. 41 (5): 308–317. doi:10.1053/j.semperi.2017.04.008. PMID   28625554.
  14. 1 2 3 Singh VP, Singh P (2024). "Linking DNA damage and senescence to gestation period and lifespan in placental mammals". Front Cell Dev Biol. 12: 1480695. doi: 10.3389/fcell.2024.1480695 . PMC   11471632 . PMID   39403126. Creative Commons by small.svg  This article incorporates textfrom this source, which is available under the CC BY 4.0 license.
  15. Neill WT (1964-01-01). "Viviparity in Snakes: Some Ecological and Zoogeographical Considerations". The American Naturalist. 98 (898): 35–55. doi:10.1086/282299. ISSN   0003-0147. S2CID   85209921.
  16. Bainbridge DR (November 2014). "The evolution of pregnancy". Early Human Development. 90 (11): 741–5. doi:10.1016/j.earlhumdev.2014.08.013. PMID   25242206.
  17. Carter AM, Soma H (August 2020). "Viviparity in the longest-living vertebrate, the Greenland shark (Somniosus microcephalus)". Placenta. 97: 26–28. doi:10.1016/j.placenta.2020.05.014. PMID   32792058. S2CID   221121663.
  18. Smith MR (October 2016). "Evolution: Velvet Worm Biogeography" (PDF). Current Biology. 26 (19): R882–R884. Bibcode:2016CBio...26.R882S. doi: 10.1016/j.cub.2016.07.067 . PMID   27728789. S2CID   4039461.
  19. Munns SL, Edwards A, Nicol S, Frappell PB (March 2015). "Pregnancy limits lung function during exercise and depresses metabolic rate in the skink Tiliqua nigrolutea". The Journal of Experimental Biology. 218 (Pt 6): 931–9. doi: 10.1242/jeb.111450 . PMID   25788728. S2CID   16426853.
  20. Hutchin K (2021-07-19). "Prehensile-tailed Skink". Ambassador Animal. Retrieved 2021-09-19.
  21. Ostrovsky AN, Lidgard S, Gordon DP, Schwaha T, Genikhovich G, Ereskovsky AV (August 2016). "Matrotrophy and placentation in invertebrates: a new paradigm". Biological Reviews of the Cambridge Philosophical Society. 91 (3): 673–711. doi:10.1111/brv.12189. PMC   5098176 . PMID   25925633.
  22. Mueller LD, Bitner K (December 2015). "The Evolution of Ovoviviparity in a Temporally Varying Environment" (PDF). The American Naturalist. 186 (6): 708–15. doi:10.1086/683661. PMID   26655978. S2CID   7447706.
  23. Thompson MB (December 2007). "Comparison of the respiratory transition at birth or hatching in viviparous and oviparous amniote vertebrates". Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 148 (4): 755–60. doi:10.1016/j.cbpa.2007.01.006. PMID   17314056.
  24. Cook DF, Voss SC, Dadour IR (November 2012). "The laying of live larvae by the blowfly Calliphora varifrons (Diptera: Calliphoridae)". Forensic Science International. 223 (1–3): 44–6. doi:10.1016/j.forsciint.2012.07.015. PMID   22921421.
  25. Scobell SK, Mackenzie DS (June 2011). "Reproductive endocrinology of Syngnathidae". Journal of Fish Biology. 78 (6): 1662–80. Bibcode:2011JFBio..78.1662S. doi: 10.1111/j.1095-8649.2011.02994.x . PMID   21651522.
  26. Wilson AB, Orr JW (June 2011). "The evolutionary origins of Syngnathidae: pipefishes and seahorses". Journal of Fish Biology. 78 (6): 1603–23. Bibcode:2011JFBio..78.1603W. doi:10.1111/j.1095-8649.2011.02988.x. PMID   21651519.
  27. Jones AG, Avise JC (October 2003). "Male pregnancy". Current Biology. 13 (20): R791. Bibcode:2003CBio...13.R791J. doi: 10.1016/j.cub.2003.09.045 . PMID   14561416.