Gil McVean

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Gil McVean

FRS FMedSci
Professor Gilean McVean FMedSci FRS (cropped).jpg
McVean in 2016
Born
Gilean Alistair Tristram McVean

February 1973 (age 50)
NationalityBritish
Alma mater
Awards
Scientific career
Institutions
Thesis Adaptation and conflict : the differences between the sexes in mammalian genome evolution  (1998)
Doctoral advisor Laurence Hurst [2] [3] [4]
Other academic advisors
Website Professor Gil McVean - University of Oxford

Gilean Alistair Tristram McVean FRS FMedSci [5] (born February 1973) [6] is a professor of statistical genetics at the University of Oxford, [7] fellow of Linacre College, Oxford and co-founder and director of Genomics plc. [6] [8] He also co-chaired the 1000 Genomes Project analysis group. [9] [10]

Contents

Education

Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton Gilean McVean.JPG
Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton

From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford. [11] He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst [12] [13] in 1998. [3] [14]

Career and research

McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth. [15] [14]

From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age. [16] In October 2006, he was appointed professor of statistical genetics at the University of Oxford. [17]

McVean's research [18] focuses on population genetics, statistics [19] and evolutionary biology including the International HapMap Project, [20] [21] recombination rates in the human genome [22] and the 1000 Genomes Project. [23] [24]

McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene. [25] In 2014, with Peter Donnelly, McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford. [6] In 2017, he was a founding director of the Big Data Institute at the University of Oxford. [26]

Honours and awards

In 2006 McVean was awarded a Philip Leverhulme Prize. [27] [28]

In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history". [29]

In 2012, he was awarded the Weldon Memorial Prize. [30]

In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories. [31]

In May 2014, McVean was elected as a member of the European Molecular Biology Organisation. [32]

McVean was elected Fellow of the Royal Society (FRS) in 2016 [5] and a Fellow of the Academy of Medical Sciences (FMedSci). [33] [34]

Related Research Articles

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<span class="mw-page-title-main">Eric Lander</span> American mathematician (born 1957)

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<span class="mw-page-title-main">Michael Ashburner</span>

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<span class="mw-page-title-main">Wellcome Sanger Institute</span> British genomics research institute

The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.

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Gabriel A. Dover was a British geneticist, best known for coining the term molecular drive in 1982 to describe a putative third evolutionary force operating distinctly from natural selection and genetic drift.

<span class="mw-page-title-main">Crick Lecture</span> Award

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<span class="mw-page-title-main">Laurence Hurst</span>

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<span class="mw-page-title-main">Wellcome Centre for Human Genetics</span>

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References

  1. ↑ "Francis Crick Medal and Lecture 2010 - Our genomes, our history". Royal Society. Retrieved 27 January 2022.
  2. ↑ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology. 6 (5): 533–36. doi: 10.1016/S0960-9822(02)00535-3 . PMID   8805261.
  3. 1 2 McVean, Gilean Alistair Tristram (1998). Adaptation and conflict: the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC   894602716.
  4. ↑ "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived from the original on 15 May 2015.
  5. 1 2 Anon (2016). "Gilean McVean". royalsociety.org. London: Royal Society. Archived from the original on 29 April 2016.
  6. 1 2 3 Anon (2016). "Gilean MCVEAN Profile". companieshouse.gov.uk. London: Companies House. Archived from the original on 12 August 2016.
  7. ↑ McVean Group at the University of Oxford
  8. ↑ "Prof. Gil McVean - GENOMICS plc" . Retrieved 30 December 2017.
  9. ↑ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Archived from the original on 10 September 2018. Retrieved 30 December 2017.
  10. ↑ Gil McVean publications from Europe PubMed Central
  11. ↑ Gil McVean's ORCID   0000-0002-5012-4162
  12. ↑ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature. 386 (6623): 388–92. Bibcode:1997Natur.386..388M. doi:10.1038/386388a0. PMID   9121553. S2CID   4343123.
  13. ↑ Hurst, L.D.; McVean, G.T. (1996). "...And scandalous symbionts". Nature. 381 (6584): 650–51. Bibcode:1996Natur.381..650H. doi: 10.1038/381650a0 . PMID   8649507.
  14. 1 2 "Gilean McVean profile". Oxford University. Archived from the original on 24 October 2017. Retrieved 30 December 2017.
  15. ↑ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution. 16 (5): 235–42. doi:10.1016/S0169-5347(01)02126-7. PMID   11301152.
  16. ↑ "Oxford University Gazette - Reappointments". ox.ac.uk. 14 May 2009. Archived from the original on 30 May 2009. Retrieved 30 December 2017.
  17. ↑ "Oxford University Gazette". ox.ac.uk. Archived from the original on 2 October 2013. Retrieved 12 July 2016.
  18. ↑ Gilean McVean profile, Google Scholar; accessed 30 December 2017.
  19. ↑ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets". Science. 334 (6062): 1518–1524. Bibcode:2011Sci...334.1518R. doi:10.1126/science.1205438. PMC   3325791 . PMID   22174245.
  20. ↑ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; et al. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature. 449 (7164): 851–61. Bibcode:2007Natur.449..851F. doi:10.1038/nature06258. PMC   2689609 . PMID   17943122.
  21. ↑ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; et al. (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature. 449 (7164): 913–918. Bibcode:2007Natur.449..913S. doi:10.1038/nature06250. PMC   2687721 . PMID   17943131.
  22. ↑ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science. 304 (5670): 581–584. Bibcode:2004Sci...304..581M. doi:10.1126/science.1092500. PMID   15105499. S2CID   20616898.
  23. ↑ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools". Bioinformatics. 27 (15): 2156–58. doi:10.1093/bioinformatics/btr330. PMC   3137218 . PMID   21653522.
  24. ↑ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science. 331 (6019): 920–24. Bibcode:2011Sci...331..920H. doi:10.1126/science.1198878. PMC   3669691 . PMID   21330547.
  25. ↑ "Gilean McVean". royalsociety.org. Retrieved 30 December 2017.
  26. ↑ "Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute". www.bdi.ox.ac.uk. Retrieved 29 April 2021.
  27. ↑ "AWARDS MADE IN 2006" (PDF). leverhulme.ac.uk. The Leverhulme Trust. 2006. Archived from the original (PDF) on 10 August 2016. Retrieved 30 December 2017.
  28. ↑ "Philip Leverhulme Prizes 2006" (PDF). leverhulme.ac.uk. The Leverhulme Trust. 2006. Retrieved 30 December 2017.
  29. ↑ The Royal Society (10 December 2013), Our genomes, our history, archived from the original on 15 December 2021, retrieved 30 December 2017
  30. ↑ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". well.ox.ac.uk. Retrieved 30 December 2017.
  31. ↑ TEDx Talks (29 March 2013), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, archived from the original on 15 December 2021, retrieved 30 December 2017
  32. ↑ "EMBO enlarges its membership for 50th anniversary". embo.org. Retrieved 30 December 2017.
  33. ↑ "New Fellows: Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 30 December 2017.
  34. ↑ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc" . Retrieved 30 December 2017.
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