Helen Sang

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Helen Mary Sang
Helen Sang at the British Library.jpg
Sang speaks at the British Library in 2014
Born1955
Alma mater University of Cambridge (BSc, PhD)
Scientific career
Institutions Roslin Institute
University of Edinburgh
Harvard University
Thesis Studies in genetic recombination in Sordaria brevicollis  (1975)
Doctoral advisor Harold Leslie Keer Whitehouse

Helen Mary Sang OBE FRSE FRSB (born 1955) is the head of the Division of Developmental Biology at the Roslin Institute of the University of Edinburgh. Her research considers the development of chickens that cannot spread avian influenza (bird flu). She has previously served on the Biotechnology and Biological Sciences Research Council.

Contents

Early life and education

Sang studied natural sciences at the University of Cambridge and graduated in 1972. [1] She earned her doctorate in the Department of Botany where she studied genetic recombination in Sordaria . She worked in the laboratory of Harold Leslie Keer Whitehouse. After earning her PhD, Sang was awarded a SERC–NATO fellowship to look at mismatch repair in E. coli working with Matthew Meselson at Harvard University. [1]

Research and career

Sang returned to the United Kingdom as a Medical Research Council fellow working with David Finnegan at the University of Edinburgh. Here she investigated the transposable element that is responsible for the I-R system of hybrid dysgenesis in Drosophila melanogaster . Sang was made principal investigator at the Agriculture and Food Research Council (AFRC) Poultry Research Centre, which became the Roslin Institute in 1993. [1] Sang has dedicated much of her research career to the genetic modification of chickens. [2] In the 1980s when Sang started at the Roslin Institute she started to investigate ways to genetically modify hens so that they created valuable proteins in their eggs. [3] [4] She proposed purifying the egg whites and making use of the engineered proteins for medical therapies to treat cancer, arthritis and multiple sclerosis. [5] Since then, genome editing has evolved so that genes can be inserted into the DNA of chickens, producing new human proteins alongside those in egg white. [6] [7] Working with Lissa Herron Sang demonstrated new ways to purify these egg proteins. [8] In 2019 she demonstrated that these hens could produce IFNalpha2a, a protein which has anti-viral and anti-cancer potential. [9] [10]

She has developed new ways to produce transgenic chickens using lentiviral vectors. [11] [12] The transgenic chickens can serve as models for investigations into vertebrate development. [13] [14] Sang and colleagues developed transgenic lines that incorporated green fluorescent protein and membrane localised green fluorescent proteins in cells that are developing embryos. These could be used for in vivo imaging or grafting to analyse lineage during embryogenesis.

In 2011 together with Laurence Tiley Sang demonstrated that she could genetically modify chickens to confer resistance to avian influenza. [15] [16] [17]

Awards and honours

Sang is a fellow of the Royal Society of Edinburgh (2008) and the Royal Society of Biology. [18] From 2015 to 2018 Sang served on the Biotechnology and Biological Sciences Research Council. Sang was appointed Officer of the Order of the British Empire (OBE) in the 2020 New Year Honours for services to food security and bioscience for health. [19] [20]

Selected publications

Her publications include:

Sang has appeared on The Naked Scientists and delivered a TED talk on the need for genetically modified chickens. [21]

Related Research Articles

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<span class="mw-page-title-main">Genetically modified organism</span> Organisms whose genetic material has been altered using genetic engineering methods

A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms.

<span class="mw-page-title-main">Genetic engineering</span> Manipulation of an organisms genome

Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms.

<span class="mw-page-title-main">Chicken</span> Domesticated species of bird

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<span class="mw-page-title-main">Genetically modified food</span> Foods produced from organisms that have had changes introduced into their DNA

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<span class="mw-page-title-main">Avian influenza</span> Influenza caused by viruses adapted to birds

Avian influenza, also known as avian flu or bird flu, is a disease caused by the influenza A virus, which primarily affects birds but can sometimes affect mammals including humans. Wild aquatic birds are the primary host of the influenza A virus, which is enzootic in many bird populations.

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Avian coronavirus is a species of virus from the genus Gammacoronavirus that infects birds; since 2018, all gammacoronaviruses which infect birds have been classified as this single species. The strain of avian coronavirus previously known as infectious bronchitis virus (IBV) is the only coronavirus that infects chickens. It causes avian infectious bronchitis, a highly infectious disease that affects the respiratory tract, gut, kidney and reproductive system. IBV affects the performance of both meat-producing and egg-producing chickens and is responsible for substantial economic loss within the poultry industry. The strain of avian coronavirus previously classified as Turkey coronavirus causes gastrointestinal disease in turkeys.

<span class="mw-page-title-main">Genetically modified crops</span> Plants used in agriculture

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<span class="mw-page-title-main">H5N1 genetic structure</span> Genetic structure of Influenza A virus

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<span class="mw-page-title-main">Genetically modified plant</span> Plants with human-introduced genes from other organisms

Genetically modified plants have been engineered for scientific research, to create new colours in plants, deliver vaccines, and to create enhanced crops. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. Many plant cells are pluripotent, meaning that a single cell from a mature plant can be harvested and then under the right conditions form a new plant. This ability is most often taken advantage by genetic engineers through selecting cells that can successfully be transformed into an adult plant which can then be grown into multiple new plants containing transgene in every cell through a process known as tissue culture.

<span class="mw-page-title-main">Genetically modified animal</span> Animal that has been genetically modified

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<span class="mw-page-title-main">Genetically modified fish</span>

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<span class="mw-page-title-main">Genetically modified rice</span>

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<span class="mw-page-title-main">Genetically modified mammal</span>

Genetically modified mammals are mammals that have been genetically engineered. They are an important category of genetically modified organisms. The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.

Genetically modified sperm (GM sperm) is sperm that has undergone genetic modification for biomedical purposes, including the elimination of genetic diseases or infertility. Although the procedure has been tested on animals such as fish, pigs, and rabbits, it remains relatively untested on humans. In the case of pigs, the goal of research is to inexpensively produce organs and supplement the shortage of donated human organs. Although GM sperm has the potential to detect and treat genetic diseases, it will likely take many years for successful use in patients.

<span class="mw-page-title-main">H5N1 vaccine</span> Vaccine designed to provide immunity against H5N1 influenza

A H5N1 vaccine is an influenza vaccine intended to provide immunization to influenza A virus subtype H5N1.

<span class="mw-page-title-main">Influenza A virus subtype H7N9</span> Subtype of the influenza A virus

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<span class="mw-page-title-main">2015 United States H5N2 outbreak</span> 2015 outbreak of avian influenza subtype H5N2

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References

  1. 1 2 3 "Professor Helen Sang". The University of Edinburgh. Retrieved 28 December 2019.
  2. Ahuja, Anjana (19 February 2016). "Are these the chickens of the future?". Financial Times. Retrieved 28 December 2019.
  3. Herron, Lissa R.; Pridans, Clare; Turnbull, Matthew L.; Smith, Nikki; Lillico, Simon; Sherman, Adrian; Gilhooley, Hazel J.; Wear, Martin; Kurian, Dominic; Papadakos, Grigorios; Digard, Paul; Hume, David A.; Gill, Andrew & Sang, Helen M. A Chicken Bioreactor for Efficient Production of Functional Cytokines. BMC. OCLC   1090948795. PMID   30594166.
  4. Highfield, Roger (7 December 2000). "Dolly team will use eggs to mass-produce medicines". Daily Telegraph. ISSN   0307-1235 . Retrieved 28 December 2019.
  5. Jha, Alok (15 January 2007). "GM hens' medicinal eggs aid cancer fight". The Guardian. ISSN   0261-3077 . Retrieved 28 December 2019.
  6. Macdonald, Kenneth (28 January 2019). "Gene modified chickens 'lay medicines'". BBC News. Retrieved 28 December 2019.
  7. "Hens that lay human proteins in eggs offer future therapy hope". ScienceDaily. Retrieved 28 December 2019.
  8. "Professor Helen Sang". UK Research and Innovation. Retrieved 28 December 2019.
  9. Barrie, Douglas (28 January 2019). "Drugs for humans laid in chicken eggs". The Times. ISSN   0140-0460 . Retrieved 28 December 2019.
  10. "GM chickens lay eggs rich with cancer-killing proteins". BBC Science Focus Magazine. Retrieved 28 December 2019.
  11. "Production of Transgenic Chickens using Lentiviral Vectors". National Avian Research Facility. Retrieved 28 December 2019.
  12. "Genetically modified chickens lay drugs in eggs". Reuters. 24 January 2007. Retrieved 28 December 2019.
  13. McGrew, Michael J.; Sherman, Adrian; Ellard, Fiona M.; Lillico, Simon G.; Gilhooley, Hazel J.; Kingsman, Alan J.; Mitrophanous, Kyriacos A. & Sang, Helen (1 July 2004). "Efficient production of germline transgenic chickens using lentiviral vectors". EMBO Reports. 5 (7): 728–733. doi:10.1038/sj.embor.7400171. ISSN   1469-221X. PMC   1299092 . PMID   15192698.
  14. Sang, Helen M. "Next generation transgenic technologies for the chick". UK Research and Innovation. Retrieved 28 December 2019.
  15. "Helen Sang - Counting your GM chickens". The Naked Scientists. 13 June 2015. Retrieved 28 December 2019.
  16. "Could avian flu-resistant chickens be a commercial reality?". WATT Ag Net. Retrieved 28 December 2019.
  17. "GM chickens that don't transmit bird flu developed". University of Cambridge. 14 January 2011. Retrieved 28 December 2019.
  18. "Professor Helen Sang FRSE". The Royal Society of Edinburgh. 17 July 2019. Retrieved 28 December 2019.
  19. "No. 62866". The London Gazette (Supplement). 28 December 2019. p. N14.
  20. "The full 2020 New Year Honours list - From Olivia Newton-John to Ben Stokes". Metro. 28 December 2019. Retrieved 28 December 2019.
  21. Why do we need GM chickens? | Helen Sang | TEDxGlasgow , retrieved 28 December 2019