Extraño a Josué
Helen Mary Sang | |
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![]() Sang speaks at the British Library in 2014 | |
Born | 1955 |
Alma mater | University of Cambridge (BSc, PhD) |
Scientific career | |
Institutions | Roslin Institute University of Edinburgh Harvard University |
Thesis | Studies in genetic recombination in Sordaria brevicollis (1975) |
Doctoral advisor | Harold Leslie Keer Whitehouse |
Helen Mary Sang OBE FRSE FRSB (born 1955) is the head of the Division of Developmental Biology at the Roslin Institute of the University of Edinburgh. Her research considers the development of chickens that cannot spread avian influenza (bird flu). She has previously served on the Biotechnology and Biological Sciences Research Council.
Sang studied natural sciences at the University of Cambridge and graduated in 1972. [1] She earned her doctorate in the Department of Botany where she studied genetic recombination in Sordaria . She worked in the laboratory of Harold Leslie Keer Whitehouse. After earning her PhD, Sang was awarded a SERC–NATO fellowship to look at mismatch repair in E. coli working with Matthew Meselson at Harvard University. [1]
Sang returned to the United Kingdom as a Medical Research Council fellow working with David Finnegan at the University of Edinburgh. Here she investigated the transposable element that is responsible for the I-R system of hybrid dysgenesis in Drosophila melanogaster . Sang was made principal investigator at the Agriculture and Food Research Council (AFRC) Poultry Research Centre, which became the Roslin Institute in 1993. [1] Sang has dedicated much of her research career to the genetic modification of chickens. [2] In the 1980s when Sang started at the Roslin Institute she started to investigate ways to genetically modify hens so that they created valuable proteins in their eggs. [3] [4] She proposed purifying the egg whites and making use of the engineered proteins for medical therapies to treat cancer, arthritis and multiple sclerosis. [5] Since then, genome editing has evolved so that genes can be inserted into the DNA of chickens, producing new human proteins alongside those in egg white. [6] [7] Working with Lissa Herron Sang demonstrated new ways to purify these egg proteins. [8] In 2019 she demonstrated that these hens could produce IFNalpha2a, a protein which has anti-viral and anti-cancer potential. [9] [10]
She has developed new ways to produce transgenic chickens using lentiviral vectors. [11] [12] The transgenic chickens can serve as models for investigations into vertebrate development. [13] [14] Sang and colleagues developed transgenic lines that incorporated green fluorescent protein and membrane localised green fluorescent proteins in cells that are developing embryos. These could be used for in vivo imaging or grafting to analyse lineage during embryogenesis.
In 2011 together with Laurence Tiley Sang demonstrated that she could genetically modify chickens to confer resistance to avian influenza. [15] [16] [17]
Sang is a fellow of the Royal Society of Edinburgh (2008) and the Royal Society of Biology. [18] From 2015 to 2018 Sang served on the Biotechnology and Biological Sciences Research Council. Sang was appointed Officer of the Order of the British Empire (OBE) in the 2020 New Year Honours for services to food security and bioscience for health. [19] [20]
Her publications include:
Sang has appeared on The Naked Scientists and delivered a TED talk on the need for genetically modified chickens. [21]
Genetically modified maize (corn) is a genetically modified crop. Specific maize strains have been genetically engineered to express agriculturally-desirable traits, including resistance to pests and to herbicides. Maize strains with both traits are now in use in multiple countries. GM maize has also caused controversy with respect to possible health effects, impact on other insects and impact on other plants via gene flow. One strain, called Starlink, was approved only for animal feed in the US but was found in food, leading to a series of recalls starting in 2000.
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), including animals, plants, and microorganisms.
Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms.
The chicken is a large and round short-winged bird, domesticated from the red junglefowl of Southeast Asia around 8,000 years ago. Most chickens are raised for food, providing meat and eggs; others are kept as pets or for cockfighting.
Genetically modified foods, also known as genetically engineered foods, or bioengineered foods are foods produced from organisms that have had changes introduced into their DNA using various methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits when compared to previous methods, such as selective breeding and mutation breeding.
Avian influenza, also known as avian flu or bird flu, is a disease caused by the influenza A virus, which primarily affects birds but can sometimes affect mammals including humans. Wild aquatic birds are the primary host of the influenza A virus, which is enzootic in many bird populations.
Anthony John Clark OBE FRSE was an English molecular biologist who was a founder of applying molecular technology to farm animals. He was director of the Roslin Institute from 2002 to 2004.
Avian coronavirus is a species of virus from the genus Gammacoronavirus that infects birds; since 2018, all gammacoronaviruses which infect birds have been classified as this single species. The strain of avian coronavirus previously known as infectious bronchitis virus (IBV) is the only coronavirus that infects chickens. It causes avian infectious bronchitis, a highly infectious disease that affects the respiratory tract, gut, kidney and reproductive system. IBV affects the performance of both meat-producing and egg-producing chickens and is responsible for substantial economic loss within the poultry industry. The strain of avian coronavirus previously classified as Turkey coronavirus causes gastrointestinal disease in turkeys.
Genetically modified crops are plants used in agriculture, the DNA of which has been modified using genetic engineering methods. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. In most cases, the aim is to introduce a new trait to the plant which does not occur naturally in the species. Examples in food crops include resistance to certain pests, diseases, environmental conditions, reduction of spoilage, resistance to chemical treatments, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents, biofuels, and other industrially useful goods, as well as for bioremediation.
The genetic structure of H5N1, a highly pathogenic avian influenza virus, is characterized by a segmented RNA genome consisting of eight gene segments that encode for various viral proteins essential for replication, host adaptation, and immune evasion.
Genetically modified plants have been engineered for scientific research, to create new colours in plants, deliver vaccines, and to create enhanced crops. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. Many plant cells are pluripotent, meaning that a single cell from a mature plant can be harvested and then under the right conditions form a new plant. This ability is most often taken advantage by genetic engineers through selecting cells that can successfully be transformed into an adult plant which can then be grown into multiple new plants containing transgene in every cell through a process known as tissue culture.
Genetically modified animals are animals that have been genetically modified for a variety of purposes including producing drugs, enhancing yields, increasing resistance to disease, etc. The vast majority of genetically modified animals are at the research stage while the number close to entering the market remains small.
Genetically modified fish are organisms from the taxonomic clade which includes the classes Agnatha, Chondrichthyes and Osteichthyes whose genetic material (DNA) has been altered using genetic engineering techniques. In most cases, the aim is to introduce a new trait to the fish which does not occur naturally in the species, i.e. transgenesis.
Genetically modified rice are rice strains that have been genetically modified. Rice plants have been modified to increase micronutrients such as vitamin A, accelerate photosynthesis, tolerate herbicides, resist pests, increase grain size, generate nutrients, flavors or produce human proteins.
Genetically modified mammals are mammals that have been genetically engineered. They are an important category of genetically modified organisms. The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.
Genetically modified sperm (GM sperm) is sperm that has undergone genetic modification for biomedical purposes, including the elimination of genetic diseases or infertility. Although the procedure has been tested on animals such as fish, pigs, and rabbits, it remains relatively untested on humans. In the case of pigs, the goal of research is to inexpensively produce organs and supplement the shortage of donated human organs. Although GM sperm has the potential to detect and treat genetic diseases, it will likely take many years for successful use in patients.
A H5N1 vaccine is an influenza vaccine intended to provide immunization to influenza A virus subtype H5N1.
Influenza A virus subtype H7N9 (A/H7N9) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic in many bird populations. The virus can spread rapidly through poultry flocks and among wild birds; it can also infect humans that have been exposed to infected birds.
In 2015, an outbreak of avian influenza subtype H5N2 was identified in a series of chicken and turkey farming operations in the Midwestern United States. By May 30, more than 43 million birds in 15 states had been destroyed as a result of the outbreak, including nearly 30 million in Iowa alone, the nation's largest egg producer. In the Midwestern U.S., the average price of eggs had increased 120% between April 22 and May 30. The effects however were seen nationwide, with prices in California up 71% in the same timeframe.
Margaret M. Perry (1930-2009) was an English molecular geneticist and embryology researcher at the University of Edinburgh whose research produced the first warm-blooded animal developed completely in vitro.