Heran Darwin

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Heran Darwin
Heran Darwin Headshot cropped.jpg
Born
Santa Monica, California, United States
Citizenship United States of America
Alma mater University of California, Los Angeles
Scientific career
FieldsMicrobiology
Institutions New York University

Katerina Heran Darwin (née Hong) is an American microbiologist and professor of microbiology at New York University Grossman School of Medicine. [1] Her research interests include the bacterial proteasome [2] and the antimicrobial effects of host-produced effectors including nitric oxide, [3] [4] copper, [5] [6] [7] and aldehydes [8]

Contents

Education and academic career

Darwin received a bachelor's degree in microbiology and molecular genetics in 1992 and a PhD in microbiology and molecular genetics in 1999, both from the University of California, Los Angeles. [1] Darwin earned her PhD studying type III secretion in Salmonella typhimurium with Virginia Miller, [9] who moved her lab to Washington University in St. Louis, MO. Darwin remained with Miller for postdoctoral training before joining the lab of Carl Nathan at Weill Medical College of Cornell University (now Weill Cornell Medicine) in New York, New York.

Darwin joined the faculty of Microbiology at New York University Grossman School of Medicine in 2004. [1] Darwin is a fellow of the American Academy of Microbiology [10] [11] since 2016 and was elected to the US National Academy of Sciences in 2024. [12]

Research

Darwin has dedicated her career to studying infectious bacteria, in particular, Mycobacterium tuberculosis , [13] the bacterium responsible for tuberculosis in humans. Darwin focuses on the characterization of the M. tuberculosis proteasome, [2] a protease complex that is key to lethal infections by M. tuberculosis and helps protect the bacterium from the innate immune defenses of the host. While characterizing the mycobacterial proteasome, Darwin's group identified the first known protein-on-protein, post-translational modification in prokaryotes called Pup (prokaryotic ubiquitin-like protein). [14] While functionally similar to eukaryotic ubiquitin, Pup's distinct biochemistry makes it a potentially attractive drug target. [15]

Darwin and her collaborators are currently investigating the extent to which host-derived aldehydes may contribute to infection control. [8]

Honors and awards

References

  1. 1 2 3 "Heran Darwin". med.nyu.edu. Retrieved 2024-05-12.
  2. 1 2 Jastrab, Jordan B.; Wang, Tong; Murphy, J. Patrick; Bai, Lin; Hu, Kuan; Merkx, Remco; Huang, Jessica; Chatterjee, Champak; Ovaa, Huib; Gygi, Steven P.; Li, Huilin; Darwin, K. Heran (2015-03-23). "An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis". Proceedings of the National Academy of Sciences. 112 (14): E1763-72. Bibcode:2015PNAS..112E1763J. doi: 10.1073/pnas.1423319112 . ISSN   0027-8424. PMC   4394314 . PMID   25831519.
  3. ↑ Samanovic, Marie I.; Tu, Shengjiang; Novák, Ondřej; Iyer, Lakshminarayan M.; McAllister, Fiona E.; Aravind, L.; Gygi, Steven P.; Hubbard, Stevan R.; Strnad, Miroslav; Darwin, K. Heran (March 2015). "Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide". Molecular Cell. 57 (6): 984–994. doi:10.1016/j.molcel.2015.01.024. ISSN   1097-2765. PMC   4369403 . PMID   25728768.
  4. ↑ Darwin, K. Heran; Ehrt, Sabine; Gutierrez-Ramos, José-Carlos; Weich, Nadine; Nathan, Carl F. (2003-12-12). "The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide". Science. 302 (5652): 1963–1966. Bibcode:2003Sci...302.1963D. doi:10.1126/science.1091176. ISSN   0036-8075. PMID   14671303.
  5. ↑ Festa, Richard A.; Jones, Marcus B.; Butler-Wu, Susan; Sinsimer, Daniel; Gerads, Russell; Bishai, William R.; Peterson, Scott N.; Darwin, K. Heran (2010-10-29). "A novel copper-responsive regulon in Mycobacterium tuberculosis". Molecular Microbiology. 79 (1): 133–148. doi:10.1111/j.1365-2958.2010.07431.x. ISSN   0950-382X. PMC   3052634 . PMID   21166899.
  6. ↑ Limón, Gina; Samhadaneh, Nora M.; Pironti, Alejandro; Darwin, K. Heran (2022-10-02). "Aldehyde inactivation of the RicR regulon sensitizesMycobacterium tuberculosisto copper". doi:10.1101/2022.09.30.510424 . Retrieved 2024-05-12.{{cite journal}}: Cite journal requires |journal= (help)
  7. ↑ Shi, Xiaoshan; Festa, Richard A.; Ioerger, Thomas R.; Butler-Wu, Susan; Sacchettini, James C.; Darwin, K. Heran; Samanovic, Marie I. (2014-02-28). "The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence". mBio. 5 (1). doi:10.1128/mbio.00876-13. ISSN   2161-2129. PMC   3944814 . PMID   24549843.
  8. 1 2 Darwin, K. Heran; Stanley, Sarah A. (April 2022). "The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors". Open Biology. 12 (4). doi:10.1098/rsob.220010. ISSN   2046-2441. PMC   9006002 . PMID   35414258.
  9. ↑ Darwin, K. Heran; Miller, Virginia L. (July 1999). "Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa". Clinical Microbiology Reviews. 12 (3): 405–428. doi:10.1128/CMR.12.3.405. ISSN   0893-8512. PMC   100246 . PMID   10398673.
  10. 1 2 "American Academy of Microbiology". ASM.org. Retrieved 2024-05-12.
  11. 1 2 "K. Heran Darwin, Ph.D." ASM.org. Retrieved 2024-05-12.
  12. 1 2 Communications, NYU Web. "Two NYU Faculty Elected to the National Academy of Sciences". www.nyu.edu. Retrieved 2024-05-12.
  13. ↑ "K Heran Darwin". scholar.google.com. Retrieved 2024-05-12.
  14. ↑ Pearce, Michael J.; Mintseris, Julian; Ferreyra, Jessica; Gygi, Steven P.; Darwin, K. Heran (2008-11-14). "Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis". Science. 322 (5904): 1104–1107. Bibcode:2008Sci...322.1104P. doi:10.1126/science.1163885. ISSN   0036-8075. PMC   2698935 . PMID   18832610.
  15. ↑ Darwin, K. Heran (July 2009). "Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis". Nature Reviews Microbiology. 7 (7): 485–491. doi:10.1038/nrmicro2148. ISSN   1740-1534. PMC   3662484 . PMID   19483713.
  16. ↑ "Grant Recipients". Burroughs Wellcome Fund. Retrieved 2024-05-15.
  17. ↑ https://research.weill.cornell.edu/sites/default/files/irma_t._hirschl_trust-mwc_-_award_recipients_12-30-19_.pdf
  18. ↑ "Heran Darwin". www.nasonline.org. Retrieved 2024-05-15.
  19. ↑ "NIH Director's Wednesday Afternoon Lecture Series 2023-2024 | NIH Office of Intramural Research". oir.nih.gov. Retrieved 2024-05-15.
  20. ↑ "2024 Laureates - HOAM". www.hoamfoundation.org. Retrieved 2024-05-15.
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