IGF2BP1

IGF2BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KRM
Identifiers
Aliases	IGF2BP1 , CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1
External IDs	OMIM: 608288; MGI: 1890357; HomoloGene: 4772; GeneCards: IGF2BP1; OMA:IGF2BP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.32 Start 48,997,385 bp [1] End 49,056,145 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 59.08 cM Start 95,957,163 bp [2] End 96,005,940 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ganglionic eminence gonad ventricular zone stromal cell of endometrium buccal mucosa cell right testis left testis placenta retinal pigment epithelium Top expressed in tail of embryo abdominal wall hand epiblast mandibular prominence maxillary prominence primitive streak genital tubercle yolk sac embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation regulator activity mRNA 3'-UTR binding protein binding nucleic acid binding mRNA 5'-UTR binding mRNA binding RNA binding Cellular component cytoplasm CRD-mediated mRNA stability complex cell projection filopodium growth cone dendritic spine axon dendrite perinuclear region of cytoplasm cytoplasmic stress granule nucleus lamellipodium nucleoplasm cytosol ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA transport negative regulation of translation pallium cell proliferation in forebrain neuronal stem cell population maintenance RNA localization regulation of translation regulation of mRNA stability involved in response to stress regulation of mRNA stability transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10642 140486 Ensembl ENSG00000159217 ENSMUSG00000013415 UniProt Q9NZI8 O88477 RefSeq (mRNA) NM_001160423 NM_006546 NM_009951 RefSeq (protein) NP_001153895 NP_006537 NP_034081 NP_001388383 NP_001388384 NP_001388385 NP_001388386 Location (UCSC) Chr 17: 49 – 49.06 Mb Chr 11: 95.96 – 96.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. ^{[5] [6] [7]}

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. ^[7]

See also

• IGF2BP2
• IGF2BP3

References

1. GRCh38: Ensembl release 89: ENSG00000159217 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013415 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC   116055 . PMID   9891060.
6. Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi: 10.1016/S0378-1119(01)00866-6 . PMID   11992722.
7. "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

Further reading

• Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J (2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons". J. Neurosci. 31 (14): 5271–85. doi: 10.1523/JNEUROSCI.2387-10.2011 . PMC   6622686 . PMID   21471362.
• Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi: 10.1042/BC20040151 . PMID   15601260. S2CID   8767105.
• Prokipcak RD, Herrick DJ, Ross J (1994). "Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA". J. Biol. Chem. 269 (12): 9261–9. doi: 10.1016/S0021-9258(17)37102-8 . PMID   8132663.
• Doyle GA, Betz NA, Leeds PF, et al. (1999). "The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins". Nucleic Acids Res. 26 (22): 5036–44. doi:10.1093/nar/26.22.5036. PMC   147974 . PMID   9801297.
• Runge S, Nielsen FC, Nielsen J, et al. (2000). "H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein". J. Biol. Chem. 275 (38): 29562–9. doi: 10.1074/jbc.M001156200 . PMID   10875929.
• Nielsen FC, Nielsen J, Kristensen MA, et al. (2003). "Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains". J. Cell Sci. 115 (Pt 10): 2087–97. doi:10.1242/jcs.115.10.2087. PMID   11973350.
• Lemm I, Ross J (2002). "Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant". Mol. Cell. Biol. 22 (12): 3959–69. doi:10.1128/MCB.22.12.3959-3969.2002. PMC   133878 . PMID   12024010.
• Ioannidis P, Mahaira L, Papadopoulou A, et al. (2003). "8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas". Int. J. Cancer. 104 (1): 54–9. doi: 10.1002/ijc.10794 . PMID   12532419. S2CID   45119038.
• Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMC   1223771 . PMID   12921532.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gu L, Shigemasa K, Ohama K (2004). "Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer". Int. J. Oncol. 24 (3): 671–8. doi:10.3892/ijo.24.3.671. PMID   14767552.
• Hansen TV, Hammer NA, Nielsen J, et al. (2004). "Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice". Mol. Cell. Biol. 24 (10): 4448–64. doi:10.1128/MCB.24.10.4448-4464.2004. PMC   400488 . PMID   15121863.
• Ioannidis P, Kottaridi C, Dimitriadis E, et al. (2004). "Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors". Cancer Lett. 209 (2): 245–50. doi:10.1016/j.canlet.2003.12.015. PMID   15159028.
• Rackham O, Brown CM (2005). "Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs". EMBO J. 23 (16): 3346–55. doi:10.1038/sj.emboj.7600341. PMC   514514 . PMID   15282548.
• Nielsen J, Kristensen MA, Willemoës M, et al. (2004). "Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability". Nucleic Acids Res. 32 (14): 4368–76. doi:10.1093/nar/gkh754. PMC   514376 . PMID   15314207.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Liao B, Patel M, Hu Y, et al. (2005). "Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells". J. Biol. Chem. 279 (47): 48716–24. doi: 10.1074/jbc.M405853200 . PMID   15355996.