IGF2BP3

IGF2BP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E44
Identifiers
Aliases	IGF2BP3 , CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin like growth factor 2 mRNA binding protein 3
External IDs	OMIM: 608259 MGI: 1890359 HomoloGene: 4773 GeneCards: IGF2BP3
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.3 Start 23,310,209 bp [1] End 23,470,491 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B2.3|6 23.82 cM Start 49,062,157 bp [2] End 49,191,891 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte amniotic fluid placenta embryo sperm ganglionic eminence monocyte retinal pigment epithelium sural nerve stromal cell of endometrium Top expressed in primitive streak maxillary prominence somite internal carotid artery medullary collecting duct abdominal wall external carotid artery ureter secondary oocyte hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA 5'-UTR binding protein binding translation regulator activity mRNA 3'-UTR binding nucleic acid binding RNA binding Cellular component nucleus cytoplasm cytosol Biological process anatomical structure morphogenesis negative regulation of translation mRNA transport protein biosynthesis regulation of translation regulation of mRNA stability transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10643 140488 Ensembl ENSG00000136231 ENSMUSG00000029814 UniProt O00425 Q9CPN8 RefSeq (mRNA) NM_006547 NM_023670 RefSeq (protein) NP_006538 NP_076159 Location (UCSC) Chr 7: 23.31 – 23.47 Mb Chr 6: 49.06 – 49.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene. ^{[5] [6] [7]}

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.

The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. ^[7]

See also

• IGF2BP1
• IGF2BP2

References

1. GRCh38: Ensembl release 89: ENSG00000136231 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029814 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC   116055 . PMID   9891060.
6. Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein". Oncogene. 14 (22): 2729–33. doi:10.1038/sj.onc.1201110. PMID   9178771. S2CID   838180.
7. "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3".

Further reading

• Yaniv K, Yisraeli JK (2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID   11992722.
• Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi: 10.1042/BC20040151 . PMID   15601260. S2CID   8767105.
• Mueller-Pillasch F, Pohl B, Wilda M, et al. (2000). "Expression of the highly conserved RNA binding protein KOC in embryogenesis". Mech. Dev. 88 (1): 95–9. doi: 10.1016/S0925-4773(99)00160-4 . PMID   10525192. S2CID   17091365.
• Zhang JY, Chan EK, Peng XX, et al. (2001). "Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies". Clin. Immunol. 100 (2): 149–56. doi:10.1006/clim.2001.5048. PMID   11465943.
• Monk D, Bentley L, Beechey C, et al. (2002). "Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome". J. Med. Genet. 39 (8): 575–81. doi:10.1136/jmg.39.8.575. PMC   1735212 . PMID   12161597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1". Biochem. J. 376 (Pt 2): 383–91. doi:10.1042/BJ20030943. PMC   1223771 . PMID   12921532.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yantiss RK, Woda BA, Fanger GR, et al. (2005). "KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas". Am. J. Surg. Pathol. 29 (2): 188–95. doi:10.1097/01.pas.0000149688.98333.54. PMID   15644775. S2CID   23121446.
• Liao B, Hu Y, Herrick DJ, Brewer G (2005). "The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells". J. Biol. Chem. 280 (18): 18517–24. doi: 10.1074/jbc.M500270200 . PMID   15753088.
• Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203–12. doi: 10.1530/rep.1.00664 . PMID   16049158.
• Feagins LA, Susnow N, Zhang HY, et al. (2006). "Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (5): G871–5. doi:10.1152/ajpgi.00383.2005. PMID   16339295. S2CID   18680471.
• Vikesaa J, Hansen TV, Jønson L, et al. (2006). "RNA-binding IMPs promote cell adhesion and invadopodia formation". EMBO J. 25 (7): 1456–68. doi:10.1038/sj.emboj.7601039. PMC   1440323 . PMID   16541107.
• Jiang Z, Chu PG, Woda BA, et al. (2006). "Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study". Lancet Oncol. 7 (7): 556–64. doi:10.1016/S1470-2045(06)70732-X. PMID   16814207.
• Li C, Rock KL, Woda BA, et al. (2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression". Mod. Pathol. 20 (2): 242–7. doi: 10.1038/modpathol.3800735 . PMID   17192788.