IGF2BP2

IGF2BP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQH
Identifiers
Aliases	IGF2BP2 , IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2
External IDs	OMIM: 608289; MGI: 1890358; HomoloGene: 4774; GeneCards: IGF2BP2; OMA:IGF2BP2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.2 Start 185,643,130 bp [1] End 185,825,042 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B1 Start 21,877,759 bp [2] End 21,982,049 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell ventricular zone sural nerve stromal cell of endometrium embryo ganglionic eminence amniotic fluid bronchial epithelial cell mucosa of paranasal sinus cartilage tissue Top expressed in primitive streak medullary collecting duct primary oocyte Paneth cell fossa renal corpuscle condyle tail of embryo genital tubercle abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA 5'-UTR binding protein binding mRNA binding translation regulator activity mRNA 3'-UTR binding nucleic acid binding RNA binding Cellular component cytoplasm cytoskeleton nucleus cytosol Biological process anatomical structure morphogenesis negative regulation of translation mRNA transport regulation of translation regulation of mRNA stability transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10644 319765 Ensembl ENSG00000073792 ENSMUSG00000033581 UniProt Q9Y6M1 Q5SF07 RefSeq (mRNA) NM_001007225 NM_001291869 NM_001291872 NM_001291873 NM_001291874 NM_001291875 NM_006548 NM_183029 RefSeq (protein) NP_001007226 NP_001278798 NP_001278801 NP_001278802 NP_001278803 NP_001278804 NP_006539 NP_898850 Location (UCSC) Chr 3: 185.64 – 185.83 Mb Chr 16: 21.88 – 21.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene. ^{[5] [6] [7]}

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[7]

See also

• IGF2BP1
• IGF2BP3

References

1. GRCh38: Ensembl release 89: ENSG00000073792 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033581 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang JY, Chan EK, Peng XX, Tan EM (May 1999). "A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma". J Exp Med. 189 (7): 1101–10. doi:10.1084/jem.189.7.1101. PMC   2193003 . PMID   10190901.
6. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development". Mol Cell Biol. 19 (2): 1262–70. doi:10.1128/MCB.19.2.1262. PMC   116055 . PMID   9891060.
7. "Entrez Gene: IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2".

Further reading

• Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins". Biol. Cell. 97 (1): 87–96. doi: 10.1042/BC20040151 . PMID   15601260. S2CID   8767105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID   12674497. S2CID   30993043.
• Brants JR, Ayoubi TA, Chada K, et al. (2004). "Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2". FEBS Lett. 569 (1–3): 277–83. doi: 10.1016/j.febslet.2004.05.075 . PMID   15225648. S2CID   31167314.
• Ping S, Wang S, Zhang J, Peng X (2005). "Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells". Int. J. Biochem. Cell Biol. 37 (3): 616–27. doi:10.1016/j.biocel.2004.08.007. PMID   15618018.
• Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203–12. doi: 10.1530/rep.1.00664 . PMID   16049158.
• Natkunam Y, Vainer G, Chen J, et al. (2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176–83. doi: 10.3324/haematol.10724 . PMID   17296566.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Cleynen I, Brants JR, Peeters K, et al. (2007). "HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB". Mol. Cancer Res. 5 (4): 363–72. doi:10.1158/1541-7786.MCR-06-0331. PMID   17426251. S2CID   21026667.