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Hemagglutinin esterase (HEs) is a glycoprotein that certain enveloped viruses possess and use as an invading mechanism. HEs helps in the attachment and destruction of certain sialic acid receptors that are found on the host cell surface. Viruses that possess HEs include influenza C virus, toroviruses, and coronaviruses of the subgenus Embecovirus. HEs is a dimer transmembrane protein consisting of two monomers, each monomer is made of three domains. The three domains are: membrane fusion, esterase, and receptor binding domains.
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Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human influenza virus. The HA-tag is derived from the HA-molecule corresponding to amino acids 98-106. HA-tag has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA-tag, which does not generally appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation and purification of the protein of interest.
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References
- ↑ "Integrative Structural and Computational Biology | Scripps Research". www.scripps.edu.
- 1 2 3 Cooper, Leigh (9 May 2017). "Profile of Ian A. Wilson". Proceedings of the National Academy of Sciences. 114 (19): 4848–4850. doi: 10.1073/pnas.1705611114 . PMC 5441727 . PMID 28439000.
- ↑ Banner, DW; Bloomer, Ac; Petsko, GA; Phillips, DC; Wilson, IA (7 September 1976). "Atomic coordinates for triose phosphate isomerase from chicken muscle". Biochemical and Biophysical Research Communications. 72 (1): 146–55. doi:10.1016/0006-291x(76)90972-4. PMID 985462.
- ↑ Wilson, I. A.; Skehel, J. J.; Wiley, D. C. (29 January 1981). "Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution". Nature. 289 (5796): 366–373. Bibcode:1981Natur.289..366W. doi:10.1038/289366a0. ISSN 0028-0836. PMID 7464906. S2CID 4327688.
- ↑ [ permanent dead link ]
- ↑ "The Scripps Research Institute - News and Views". www.scripps.edu.
- ↑ Elsliger, MA; Deacon, AM; Godzik, A; Lesley, SA; Wooley, J; Wüthrich, K; Wilson, IA (1 October 2010). "The JCSG high-throughput structural biology pipeline". Acta Crystallographica Section F. 66 (Pt 10): 1137–42. doi:10.1107/S1744309110038212. PMC 2954196 . PMID 20944202.
- ↑ National Academy of Sciences Members and Foreign Associates Elected, News from the National Academy of Sciences, National Academy of Sciences, 3 May 2016, archived from the original on 6 May 2016, retrieved 14 May 2016.
