Indolizine

Indolizine

Names
Preferred IUPAC name Indolizine [1]
Other names Pyrrocoline; Indolizin; Pyrrolo[1,2-a]pyridine
Identifiers
CAS Number	274-40-8  Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:35583  Y
ChemSpider	8875  Y
ECHA InfoCard	100.219.195
PubChem CID	9230
UNII	B48FMH8YFQ  Y
CompTox Dashboard (EPA)	DTXSID50181818
InChI InChI=1S/C8H7N/c1-2-6-9-7-3-5-8(9)4-1/h1-7H Y Key: HOBCFUWDNJPFHB-UHFFFAOYSA-N Y InChI=1/C8H7N/c1-2-6-9-7-3-5-8(9)4-1/h1-7H Key: HOBCFUWDNJPFHB-UHFFFAOYAH
SMILES c1ccc2ccccn12
Properties
Chemical formula	C8H7N
Molar mass	117.151 g·mol−1
Appearance	White solid
Melting point	75 °C (167 °F; 348 K)
Boiling point	205 °C (401 °F; 478 K)
Basicity (pKb)	10.1 [2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y  verify  (what is  YN ?) Infobox references

Indolizine is an heterocyclic compound with the formula C₈H₇N). It is an uncommon isomer of indole with the nitrogen located at a ring fusion position. The saturated analog is indolizidine, which is the core of a variety of alkaloids such as swainsonine. ^[3]

Examples of some simple fully synthetic substituted indolizines include 2ZEDMA, 1ZP2MA, and 1Z2MAP1O. ^{[4] [5]}

References

1. International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 213. doi:10.1039/9781849733069. ISBN   978-0-85404-182-4.
2. Elattar, K.M.; Youssef, I.; Fadda, A.A. (4 May 2016). "Reactivity of indolizines in organic synthesis". Synthetic Communications Reviews. 46 (9): 719–744. doi:10.1080/00397911.2016.1166252. S2CID   100777050.
3. Julio Alvarez-Builla; Juan Jose Vaquero; José Barluenga, eds. (2011). Modern Heterocyclic Chemistry. Wiley-VCH.
4. WOapplication 2023081306A1, Baggott MJ,"Indolizine compounds for the treatment of mental disorders or mental enhancement",published 11 May 2023, assigned to Tactogen  
5. WOpatent 2023183613A2, Baggott MJ,"Indolizine compounds for the treatment of mental disorders or inflammation",published 2023 September 28, assigned to Tactogen  

External links

• Chemical synthesis of indolizines