JAG2

JAG2
Identifiers
Aliases	JAG2 , HJ2, SER2, jagged 2, jagged canonical Notch ligand 2, LGMDR27
External IDs	OMIM: 602570; MGI: 1098270; HomoloGene: 1677; GeneCards: JAG2; OMA:JAG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.33 Start 105,140,982 bp [1] End 105,168,824 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 F1|12 61.37 cM Start 112,871,439 bp [2] End 112,893,396 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple apex of heart pituitary gland skin of abdomen anterior pituitary skin of leg skin of thigh endothelial cell olfactory zone of nasal mucosa right frontal lobe Top expressed in lip primary oocyte molar secondary oocyte esophagus superior frontal gyrus corneal stroma hair follicle muscle of thigh external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Notch binding protein binding growth factor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process Notch signaling pathway skeletal system development respiratory system process epithelial cell apoptotic process involved in palatal shelf morphogenesis in utero embryonic development multicellular organism development odontogenesis of dentin-containing tooth cell communication auditory receptor cell fate commitment T cell differentiation regulation of cell adhesion spermatogenesis morphogenesis of embryonic epithelium gamma-delta T cell differentiation thymic T cell selection positive regulation of Notch signaling pathway cell differentiation regulation of cell population proliferation regulation of signaling receptor activity negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3714 16450 Ensembl ENSG00000184916 ENSMUSG00000002799 UniProt Q9Y219 Q9QYE5 RefSeq (mRNA) NM_002226 NM_145159 NM_010588 RefSeq (protein) NP_002217 NP_660142 NP_034718 Location (UCSC) Chr 14: 105.14 – 105.17 Mb Chr 12: 112.87 – 112.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Jagged-2 is a protein that in humans is encoded by the JAG2 gene. ^{[5] [6] [7]}

Function

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

Interactions

JAG2 has been shown to interact with NOTCH2. ^[8]

MicroRNA miR-1280 has been shown to inhibit JAG2 expression. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000184916 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002799 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J (October 1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol Cell Biol. 17 (10): 6057–67. doi:10.1128/MCB.17.10.6057. PMC   232455 . PMID   9315665.
6. Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L (April 2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID   10662552.
7. "Entrez Gene: JAG2 jagged 2".
8. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC   88767 . PMID   10958687.
9. Wang, Remke, Bhat, Wong, Zhou, Ramaswamy, Dubuc, Fonkem, Salem, Zhang, Hsieh, O'Rourke, Wu, Li, Hawkins, Kohane, Wu, Wu, Taylor (February 2015). "A MicroRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma". Oncotarget. 6 (5): 2709–24. doi:10.18632/oncotarget.2779. PMC   4413612 . PMID   25576913.

Further reading

• Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi: 10.1006/dbio.1996.0310 . PMID   8948600.
• Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. doi:10.1016/S0925-4773(97)00146-9. PMID   9486542. S2CID   15978116.
• Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC   1866435 . PMID   10079256.
• Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, Kelley MW (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID   10080181. S2CID   6801552.
• Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. doi: 10.1093/intimm/11.7.1017 . PMID   10383933.
• Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood. 96 (3): 950–7. doi:10.1182/blood.V96.3.950. PMID   10910909.
• Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC   88767 . PMID   10958687.
• Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID   11006133.
• Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID   11056013. S2CID   683811.
• Lindner V, Booth C, Prudovsky I, Small D, Maciag T, Liaw L (2001). "Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction". Am. J. Pathol. 159 (3): 875–83. doi:10.1016/S0002-9440(10)61763-4. PMC   1850458 . PMID   11549580.
• Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. doi:10.1002/j.1939-4640.2001.tb03441.x. PMID   11700865.
• Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi: 10.1074/jbc.C200711200 . PMID   12551931.
• Houde C, Li Y, Song L, Barton K, Zhang Q, Godwin J, Nand S, Toor A, Alkan S, Smadja NV, Avet-Loiseau H, Lima CS, Miele L, Coignet LJ (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 (12): 3697–704. doi: 10.1182/blood-2003-12-4114 . PMID   15292061.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.