Neurogenic locus notch homolog protein 1(Notch 1) is a protein encoded in humans by the NOTCH1 gene. [5] Notch 1 is a single-pass transmembrane receptor.
This gene encodes a member of the Notch family. Members of this type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila , notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [6]
A deficiency can be associated with bicuspid aortic valve. [7]
There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. [8] Notch 1, when activated before birth, induces radial glia differentiation, [9] but postnatally induces the differentiation into astrocytes. [10] One study shows that Notch-1 cascade is activated by Reelin in an unidentified way. [11] Reelin and Notch1 cooperate in the development of the dentate gyrus, according to another. [12]
NOTCH1 has been shown to interact with: