| KIAA0895L | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KIAA0895L , KIAA0895 like | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1921606 HomoloGene: 47588 GeneCards: KIAA0895L | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Uncharacterized protein KIAA0895-like also known as LOC653319, is a protein that in humans is encoded by the KIAA0895L gene. [5]
KIAA0895L is located at q22.1 on chromosome 16 of the human genome. [6] Its genomic DNA consists of 8,379 base pairs. [7] KIAA0895L is located between EXOC3L and E2F4 on the right, and NOL3 and HSF4 on the left. [8] The promoter for KIAA0895L is located on chromosome 16 and spans 67217367-67218383bp. [9] [10]
KIAA0895L was first documented by the Mammalian Gene Collection Program Team in 2002. [11] There are several patents on KIAA0895L, two of those being patent US 6943241 and patent EP1308459. [12]
KIAA0895L orthologs can be found in all mammals. [13] It is not found in plants, archaea, or fungi. KIAA0895L has a single paralog, known as KIAA0895. [14]
The known orthologs of KIAA0895L are listed below: [15] [16]
| Domain of unknown function 1704 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DUF1704 | ||||||||
| Pfam | PF08014 | ||||||||
| InterPro | IPR012548 | ||||||||
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KIAA0895L is composed of 471 amino acids (53.5kDa). [17] A proline-rich region was also revealed at 14-65 amino acids. [18] There is also an area of low complexity at 2913-2917 bp in the 3’ UTR region. [19] [20] There is a conserved domain of unknown function, known as DUF1704, located at 1390-2083 bp. [21]
The following is a list of predicted post translational modifications found for KIAA0895L. [22] These are predicted in all mammalian orthologs in the public sequence database.
| type of modification | residues modified |
|---|---|
| O-GlaNAc glycosylation | T19, T96, T174, and T314 |
| Ser, Thr, and Tyr phosphorylation | S16, S20, S23, S31, S80, S82, S85, S88, S136, S349, S419, T96, T112, T125, T284, T379, T406, Y84, Y360, and Y420 |
| Kinase-specific phosphorylation | T96 and T125 |
No proteins that interact with KIAA0895L or its homolog have yet been identified.
KIAA0895L is expressed in many tissues of the body such as brain, testis, mammary glands, bladder, and the eye. [23]
KIAA0895L has been shown to be up regulated [24] in lymphoblastoid cells from males with autism that is caused by an expansion of a CGG repeat in the promoter region of the fragile X mental retardation 1 gene located at Xq27.3 [25] as well as in cells with a 15q11-q13 mutation.
Uncharacterized protein KIAA1109 is a protein that in humans is encoded by the KIAA1109 gene.
GeneCards is a database of human genes that provides genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes. It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science, in collaboration with LifeMap Sciences.
KIAA0895 is a protein that in Homo sapiens is encoded by the KIAA0895 gene. The gene encodes a protein commonly known as the KIAA0895 protein. It's aliases include hypothetical protein LOC23366, OTTHUMP00000206979, OTTHUMP00000206980, 9530077C05Rik, and 1110003N12Rik. It is located at 7p14.2.
Chromosome X open reading frame 36 (CXorf36) is a gene that in humans encodes a protein “hypothetical protein LOC79742”. This protein has a function that is not currently very well understood. Other known aliases are “FLJ14103, DKFZp313K0825, FLJ55198, PRO3743, FLJ55198, hCG1981635, bA435K1.1,” and “4930578C19Rik.”
KIAA1704, also known as LSR7, is a protein that in humans is encoded by the GPALPP1 gene. The function of KIAA1704 is not yet well understood. KIAA1704 contains one domain of unknown function, DUF3752. The protein contains a conserved, uncharged, repeated motif GPALPP(GF) near the N terminus and an unusual, conserved, mixed charge throughout. It is predicted to be localized to the nucleus.
Glutamine-rich protein 2 is a protein that in humans is decoded by the QRICH2 gene on human chromosome 17. The function of QRICH2 protein is mostly unknown, but it has been shown that QRICH2 gene contains a high molecular weight Glutenin domain and an ATPase involved domain. QRICH2 gene is highly expressed in testis, and the subcellular location of QRICH2 protein is in the nucleus.
Family with Sequence Similarity 203, Member B (FAM203B) is a protein encoded by the FAM203B gene (8q24.3) in humans. While FAM203B is only found in humans and possibly non-human primates, its paralog, FAM203A, is highly conserved. The FAM203B protein contains two conserved domains of unknown function, DUF383 and DUF384, and no transmembrane domains. This protein has no known function yet, although the homolog of FAM203A in Caenorhabditis elegans (Y54H5A.2) is thought to help regulate the actin cytoskeleton.
KIAA1841 is a gene in humans that encodes a protein known as KIAA1841. KIAA1841 is targeted for the nucleus and it predicted to play a role in regulating transcription.
Family with sequence similarity 63, member A is a protein that, in humans, is encoded by the FAM63A gene. It is located on the minus strand of chromosome 1 at locus 1q21.3.
Ankyrin repeat domain-containing protein 24 is a protein in humans that is coded for by the ANKRD24 gene. The gene is also known as KIAA1981. The protein's function in humans is currently unknown. ANKRD24 is in the protein family that contains ankyrin-repeat domains.
Vexin is a protein encoded by VXN gene. VXN is found to be highly expressed in regions of the brain and spinal cord.
Transmembrane Protein 176B, or TMEM176B is a transmembrane protein that in humans is encoded by the TMEM176B gene. It is thought to play a role in the process of maturation of dendritic cells.
KIAA1211L is a protein that in humans is encoded by the KIAA1211L gene. It is highly expressed in the brain. Furthermore, it is localized to the microtubules and the centrosomes and is subcellularly located in the nucleus. Finally, KIAA1211L is associated with certain mental disorders and various cancers.
Chromosome 21 Open Reading Frame 58 (C21orf58) is a protein that in humans is encoded by the C21orf58 gene.
Chromosome 19 open reading frame 44 is a protein that in humans is encoded by the C19orf44 gene. C19orf44 is an uncharacterized protein with an unknown function in humans. C19orf44 is non-limiting implying that the protein exists in other species besides human. The protein contains one domain of unknown function (DUF) that is highly conserved throughout its orthologs. This protein is most highly expressed in the testis and ovary, but also has significant expression in the thyroid and parathyroid. Other names for this protein include: LOC84167.
Transmembrane protein 179 is a protein that in humans is encoded by the TMEM179 gene. The function of transmembrane protein 179 is not yet well understood, but it is believed to have a function in the nervous system.
The FAM214B, also known as protein family with sequence similarity 214, B (FAM214B) is a protein that, in humans, is encoded by the FAM214B gene located on the human chromosome 9. The protein has 538 amino acids. The gene contain 9 exon. There has been studies that there are low expression of this gene in patients with major depression disorder. In most organisms such as mammals, amphibians, reptiles, and birds, there are high levels of gene expression in the bone marrow and blood. For humans in fetal development, FAM214B is mostly expressed in the brains and bone marrow.
C4orf19 is a protein which in humans is encoded by the C4orf19 gene.
Transmembrane protein 212 is a protein that in humans is encoded by the TMEM212 gene. The protein consists of 5 transmembrane domains and localizes in the plasma membrane and endoplasmic reticulum. TMEM212 has orthologs in vertebrates but not invertebrates. TMEM212 has been associated with sporadic Parkinson's disease, facial processing, and adiposity in African Americans.
Human uncharacterized protein CXorf65 is encoded by the gene CXorf65, which is located on the minus strand of chromosome X. Its transcript is 834 nucleotides long and consists of 6 exons. The translated protein is 183 amino acids in length. with a molecular weight of 21.3 kDa
