| KIAA1958 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KIAA1958 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 617390 HomoloGene: 136743 GeneCards: KIAA1958 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene. [3] Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.
KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597. [4] Its mRNA has 2683 bp. [3] The gene has these neighbors on chromosome 9:
HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding. [5]
C9orf147: Chromosome 9 open reading frame 147 has an unknown function. [6]
C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability. [7]
SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding. [8]
KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST. [9] The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors. [9] Data from NCBI GEO Profile [10] shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells. [11] KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells [11] and both the embryonic stem cell and the pluripotent stem cell. [11]
KIAA1958 is composed of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375. [12] Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.
PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein. [13] According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.
There is no known proof that KIAA1958 interacts with any other proteins at this time. [14]
| Genus and Species | Common Name | Accession Number | Seq. Length | Seq. Identity | Seq. Similarity |
| Pan troglodytes | Chimpanzee | XM_528391 | 7945 bp | 99% | 99% |
| Mus musculus | Mouse | BAC38268 | 719 a | 97% | 98% |
| Callithrix jacchus | Common marmoset | XM_002743204 | 2346bp | 97% | 82% |
| Pongo abelii | Sumatran Orangutan | XM_002820112 | 1120bp | 96% | 4% |
| Sus scrofa | Wild boar | XM_003122070 | 2502 bp | 93% | 81% |
| Ailuropoda melanoleuca | Giant Panda | XM_002925938 | 2151 bp | 85% | 91% |
| Nomascus leucogenys | White cheeked gibbon | XM_003263945 | 950 bp | 93% | 5% |
| Oryctolagus cuniculus | European rabbit | XM_002707990 | 2223 bp | 93% | 43% |
| Loxodonta africana | African bush elephant | XM_003407521 | 2388 bp | 93% | 80% |
| Cricetulus griseus | Chinese hamster | XM_003505508 | 2534 bp | 92% | 42% |
| Equus caballus | Horse | XM_001916302 | 2536 bp | 91% | 93% |
| Bos taurus | Cow | XM_876102.5 | 2480 bp | 91% | 81% |
| Rattus norvegicus | Rat | XM_002726532 | 1364 bp | 91% | 36% |
| Cavia porcellus | Guinea pig | XM_003463791 | 2217 bp | 91% | 43% |
| Monodelphis domestica | Opossum | XM_001375976 | 2217 bp | 78% | 41% |
| Branchiostoma floridae | Lancelet | XP_002611438 | 719 a | 29% | 48% |
| Amphimedon queenslandica | Sponge | XP_003390994 | 388 a | 25% | 48% |
| Acyrthosiphon pisum | Pea aphid | XP_001943720 | 1197 aa | 24% | 43% |
| Oikopleura dioica | Chordate | CBY34656 | 629 a | 22% | 43% |
| Ciona intestinalis | Vase tunicate | XP_002125964 | 1004 aa | 23% | 43% |
| Xenopus (silurana) tropicalis | Western Clawed frog | AAI61073 | 679 a | 23% | 43% |
| Halocynthia roretzi | Sea pineapple | BAB40645 | 980 a | 23% | 45% |
Chromosome 13 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 13 spans about 113 million base pairs and represents between 3.5 and 4% of the total DNA in cells.
Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 146 million base pairs and represents between 4.5 and 5.0% of the total DNA in cells.
Chromosome 9 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome, as they normally do with all chromosomes. Chromosome 9 spans about 150 million base pairs of nucleic acids and represents between 4.0 and 4.5% of the total DNA in cells.
Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 135 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells. The shorter arm is termed 11p while the longer arm is 11q. At about 21.5 genes per megabase, chromosome 11 is one of the most gene-rich, and disease-rich, chromosomes in the human genome.
MAP11 is a protein that in human is encoded by the gene MAP11. It was previously referred to by the generic name C7orf43. C7orf43 has no other human alias, but in mice can be found as BC037034.
TSR3, or TSR3 Ribosome Maturation Factor, is a hypothetical human protein found on chromosome 16. Its protein is 312 amino acids long. and its cDNA has 1214 base pairs It was previously designated C16orf42.
METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans.
Cilia And Flagella Associated Protein 206 (CFAP206) is a gene that in humans encodes a protein “DUF3508”. This protein has a function that is not currently very well understood. Other known aliases are “dJ382I10.1, UPF0704 Protein C6orf165.” In humans, the gene coding sequence is 56,501 base pairs long, with an mRNA of 2,215 base pairs, and a protein sequence of 622 amino acids. The C6orf165 gene is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, frog, and more C6orf165 is rarely expressed in humans, with relatively high expression in brain, lungs (trachea) and testis. The molecular weight of UPF0704 is 71,193 Da and the PI is 6.38
WD repeat-containing protein 90 is a protein that, in humans, is encoded by the WDR90 gene (16p13.3). This human protein is 1750 amino acids, and has a molecular weight of 187.7 kDa. It contains multiple WD40 repeat domains and one domain of unknown function. This protein is conserved all the way back to invertebrates. Proteins containing WD transducin repeating domains have been found to play a role in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis.
C6orf222 is a protein that in humans is encoded by the C6orf222 gene (6p21.31). C6orf222 is conserved in mammals, birds and reptiles with the most distant ortholog being the green sea turtle, Chelonia mydas. The C6orf222 protein contains one mammalian conserved domain: DUF3293. The protein is also predicted to contain a BH3 domain, which has predicted conservation in distant orthologs from the clade Aves.
Chromosome 16 open reading frame 95 (C16orf95) is a gene which in humans encodes the protein C16orf95. It has orthologs in mammals, and is expressed at a low level in many tissues. C16orf95 evolves quickly compared to other proteins.
Chromosome 15 open reading frame 52 is a human protein encoded by the C15orf52 gene, its function is poorly understood.
OCC-1 is a protein, which in humans is encoded by the gene C12orf75. The gene is approximately 40,882 bp long and encodes 63 amino acids. OCC-1 is ubiquitously expressed throughout the human body. OCC-1 has shown to be overexpressed in various colon carcinomas. Novel splice variant of this gene was also detected in various human cancer types; in addition to encoding a novel smaller protein, OCC-1 gene produces a non-protein coding RNA splice variant lncRNA.
C14orf93 is a protein that is encoded in humans by the C14orf93 gene. It is a globular protein with a conserved C-terminus that is localized to the nucleus. While expressed relatively highly in all tissues except nervous tissue, it is expressed particularly highly in T cells and other immune tissues.
Uncharacterized protein Chromosome 16 Open Reading Frame 71 is a protein in humans, encoded by the C16orf71 gene. The gene is expressed in epithelial tissue of the respiratory system, adipose tissue, and the testes. Predicted associated biological processes of the gene include regulation of the cell cycle, cell proliferation, apoptosis, and cell differentiation in those tissue types. 1357 bp of the gene are antisense to spliced genes ZNF500 and ANKS3, indicating the possibility of regulated alternate expression.
KIAA1211L is a protein that in humans is encoded by the KIAA1211L gene. It is highly expressed in the brain. Furthermore, it is localized to the microtubules and the centrosomes and is subcellularly located in the nucleus. Finally, KIAA1211L is associated with certain mental disorders and various cancers.
Chromosome 8 open reading frame 58 is an uncharacterised protein that in humans is encoded by the C8orf58 gene. The protein is predicted to be localized in the nucleus.
Chromosome 19 open reading frame 18 (c19orf18) is a protein which in humans is encoded by the c19orf18 gene. The gene is exclusive to mammals and the protein is predicted to have a transmembrane domain and a coiled coil stretch. This protein has a function that is not yet fully understood by the scientific community.
Chromosome 20 open reading frame 85, or most commonly known as C20orf85 is a gene that encodes for the C20orf85 Protein. This gene is not yet well understood by the scientific community.
