The highest-selling singles in Japan are ranked in the Oricon Weekly Chart, which is published by Oricon Style magazine. [1] The data are compiled by Oricon based on each singles' weekly physical sales. [2] In 2010 25 singles reached number-one.
| Issue Date | Singles | Artist(s) | Reference(s) |
|---|---|---|---|
| January 4 | "Gift (White)" | Kanjani Eight | [3] |
| January 18 | "You Were.../Ballad" | Ayumi Hamasaki | [4] |
| January 25 | "Phantom Minds" | Nana Mizuki | [5] |
| February 1 | "Gloria" | Yui | [6] |
| February 8 | "Break Out!" | TVXQ | [7] |
| February 15 | "Modorenai Ashita" (戻れない明日; Tomorrow When I Can't Come Back) | Aiko | [8] |
| February 22 | "Love Yourself (Kimi ga Kirai na Kimi ga Suki)" | KAT-TUN | [9] |
| March 1 | "Sakura no Shiori" | AKB48 | [10] |
| March 8 | "Hitomi no Screen" | Hey! Say! JUMP | [11] |
| March 15 | "Troublemaker" | Arashi | [12] |
| March 22 | "Lion" (ライオン, Raion) | Yusuke | [13] |
| March 29 | "AkKanbe Bashi" (アッカンベー橋; Akkanbē Bridge) | Watarirouka Hashiritai | [14] |
| April 5 | "Toki o Tomete" | TVXQ | [15] |
| April 12 | "Sakura Girl" (さくらガール, Sakura Gāru; Cherry Blossom Girl) | NEWS | [16] |
| April 19 | "Yūki 100%" | NYC | [17] |
| April 26 | "Happy" | Bump of Chicken | [18] |
| May 3 | "Mahō no Ryōri (Kimi Kara Kimi e)" | [19] | |
| May 10 | "Go! Go! Maniac" | Ho-kago Tea Time [ broken anchor ] | [20] |
| May 17 | "Aitai Riyū/Dream After Dream (Yume Kara Sameta Yume)" | AAA | [21] |
| May 24 | "Going!" | KAT-TUN | [22] |
| May 31 | "Monster" | Arashi | [23] |
| June 7 | "Ponytail to Chouchou" | AKB48 | [24] |
| June 14 | "To Mother" | Yui | [25] |
| June 21 | "Ring a Ding Dong" | Kaela Kimura | [26] |
| June 28 | "Haruka" | Tokio | [27] |
| July 5 | "Okay" | Koshi Inaba | [28] |
| July 12 | "Wonderful World!!" | Kanjani Eight | [29] |
| July 19 | "To Be Free" | Arashi | [30] |
| July 26 | "Moon/Blossom" | Ayumi Hamasaki | [31] |
| August 2 | "Kokoro no Hane" (心の羽根; Wings of the Heart) | Team Dragon From AKB48 | [32] |
| August 9 | "One in a Million" | Tomohisa Yamashita | [33] |
| August 16 | "This Is Love" | SMAP | [34] |
| August 23 | "Hotaru/Shōnen" | Masaharu Fukuyama | [35] |
| August 30 | "Heavy Rotation" | AKB48 | [36] |
| September 6 | "Life (Me no Mae no Mukou e)" | Kanjani Eight | [37] |
| September 13 | "Only Dreaming/Catch" | V6 | [38] |
| September 20 | "Love Rainbow" | Arashi | [39] |
| September 27 | "Motto Tsuyoku" (もっと強く; Stronger) | Exile | [40] |
| October 4 | "Crossroad" | Ayumi Hamasaki | [41] |
| October 11 | "L" | [42] | |
| October 18 | "Dear Snow" | Arashi | [43] |
| October 25 | "Uchūhikōshi e no Tegami/Motorcycle" (宇宙飛行士への手紙/モーターサイクル; Letter to Astronaut/Mōtāsaikuru) | Bump of Chicken | [44] |
| November 1 | "Yoku Asobi Yoku Manabe" (よく遊びよく学べ; Lots of Play, Lots of Study) | NYC | [45] |
| November 8 | "Beginner" | AKB48 | [46] |
| November 15 | "Fighting Man" | NEWS | [47] |
| November 22 | "Hatenai Sora" | Arashi | [48] |
| November 29 | "Change Ur World" | KAT-TUN | [49] |
| December 6 | "Ai wa Takaramono" (愛はタカラモノ; Love Is Treasure) | Tackey & Tsubasa | [50] |
| December 13 | "Family (Hitotsu ni Naru Koto)" (Family ~ひとつになること; Family (To Become One)) | KinKi Kids | [51] |
| December 20 | "Chance no Junban" | AKB48 | [52] |
| December 27 | "Arigatō (Sekai no Doko ni Ite mo)" | Hey! Say! JUMP | [53] |