List of adverse effects of aripiprazole

The rates of adverse effects of aripiprazole are: ^{[1] [2] [3] [4] [5]}

Adults

Very common (>10% incidence)

• Weight gain
• Headache
• Agitation
• Insomnia
• Anxiety
• Nausea & vomiting
• Akathisia — a sense of unease and restlessness that presents itself with anxiety
• Lightheadedness
• Constipation
• Emotional instability
• Euphoria or Dysphoria

Common (1–10% incidence)

• Dizziness
• Dyspepsia — indigestion
• Somnolence — which is usually mild and transient and less severe than that seen with most antipsychotics. ^[6]
• Fatigue
• Restlessness
• Dry mouth
• Extrapyramidal side effects (e.g. dystonia, parkinsonism, tremor, myoclonic jerks, etc.)
• Orthostatic hypotension
• Musculoskeletal stiffness
• Abdominal discomfort
• Blurred vision
• Cough
• Pain
• Myalgia
• Rash
• Rhinitis

Uncommon (0.1–1% incidence)

• Leukopenia
• Thrombocytopenia
• Bradycardia (low heart rate)
• Palpitations
• Orthostatic hypotension
• Dry eye
• Photophobia
• Diplopia
• Eyelid oedema
• Photopsia
• Diarrhoea
• Gastritis
• Pathological gambling ^[7]
• Dysphagia
• Gastroesophageal reflux disease
• Swollen tongue
• Oesophagitis
• Hypoaesthesia oral
• Face oedema
• Gait disturbance
• Chills
• Discomfort
• Feeling abnormal
• Mobility decreased
• Self-mutilation
• Heart rate increased
• Blood glucose increased
• Pyrexia
• Blood prolactin increased
• Blood urea increased
• Electrocardiogram QT prolonged
• Blood bilirubin increased
• Hepatic enzyme increased
• Increased appetite
• Nocturia
• Polyuria
• Pollakiuria
• Incontinence
• Urinary retention
• Sexual dysfunction
• Amenorrhoea
• Pruritus
• Photosensitivity reaction
• Urticaria

Rare (<0.1%)

• Neuroleptic malignant syndrome (Combination of fever, muscle stiffness, faster breathing, sweating, reduced consciousness, and sudden change in blood pressure and heart rate)
• Neutropenia ^[8]
• Suicidal ideation and behavior
• Depression
• Painful and/or sustained erection (Priapism)
• Seizures ^[9]
• Rhabdomyolysis
• Agranulocytosis
• Cardiopulmonary failure
• Myocardial infarction (heart attack)
• Atrial flutter
• Supraventricular tachycardia
• Ventricular tachycardia
• Atrioventricular block
• Extrasystoles
• Sinus tachycardia
• Atrial fibrillation
• Angina pectoris
• Myocardial ischaemia
• Pancreatitis
• Diabetic ketoacidosis
• Prolonged QT interval (less common than with most other atypical antipsychotic drugs) ^[6]
• Speech disorder
• Electrolyte abnormalities including hyponatraemia, hypokalaemia, hypocalcaemia, etc.
• Hypertension
• Dysphagia
• Oropharyngeal spasm
• Laryngospasm
• Hepatitis
• Jaundice
• Hypersalivation
• Chest pain
• Urinary retention or incontinence
• Alopecia (hair loss)
• Photosensitivity reaction
• Rash
• Xerostomia (when given by injection)
• Tardive dyskinesia (As with all antipsychotic medication, patients using aripiprazole may develop the permanent neurological disorder tardive dyskinesia.) ^{[10] [11] [12]}
• Stroke
• Transient Ischaemic Attack
• Increased body temperature
• Angioedema
• Cardiorespiratory arrest
• Cardiorespiratory failure

Sudden unexplained death has been reported, however the frequency is unknown. ^[13]

Common in children

• Feeling sleepy
• Headache
• Vomiting
• Fatigue
• Increased appetite
• Insomnia
• Nausea
• Stuffy nose
• Weight gain
• Uncontrolled movement such as restlessness, tremor muscle stiffness ^[7]

References

1. "Product Information for ABILIFY Aripiprazole Tablets & Orally Disintegrating Tablets". TGA eBusiness Services. Bristol-Myers Squibb Australia Pty Ltd. 1 November 2012. Retrieved 22 October 2013.
2. "ABILIFY (aripiprazole) tablet ABILIFY (aripiprazole) solution ABILIFY DISCMELT (aripiprazole) tablet, orally disintegrating ABILIFY (aripiprazole) injection, solution [Otsuka America Pharmaceutical, Inc.]". DailyMed. Otsuka America Pharmaceutical, Inc. April 2013. Retrieved 22 October 2013.
3. "Abilify Tablets, Orodispersible Tablets, Oral Solution - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Archived from the original on 4 March 2016. Retrieved 22 October 2013.
4. "ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF). European Medicines Agency. Otsuka Pharmaceutical Europe Ltd. Retrieved 22 October 2013.
5. "Abilify Discmelt, Abilify Maintena (aripiprazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 October 2013.
6. Leucht S, Cipriani A, Spineli L, Mavridis D, Orey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, Lässig B, Salanti G, Davis JM (September 2013). "Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis". Lancet. 382 (9896): 951–962. doi:10.1016/S0140-6736(13)60733-3. PMID   23810019. S2CID   32085212.
7. "ABILIFY (aripiprazole) [package insert]" (PDF). Otsuka Pharmaceutical Co, Ltd. Retrieved 18 October 2012.
8. Felin, Tricia; Naveed, Sadiq; Chaudhary, Amna M. (2018-05-01). "Aripiprazole-Induced Neutropenia: Case Report and Literature Review". Journal of Psychosocial Nursing and Mental Health Services. 56 (5). SLACK, Inc.: 21–24. doi:10.3928/02793695-20180419-02. ISSN   0279-3695. PMID   29715374.
9. Thabet, Farouq I.; Sweis, Rochelle T.; Joseph, Suja A. (2013). "Aripiprazole-Induced Seizure in a 3-Year-Old Child". Clinical Neuropharmacology. 36 (1). Ovid Technologies (Wolters Kluwer Health): 29–30. doi:10.1097/wnf.0b013e3182767efb. ISSN   0362-5664. PMID   23334073.
10. Abbasian C, Power P (March 2009). "A case of aripiprazole and tardive dyskinesia". J Psychopharmacol (Oxford). 23 (2): 214–5. doi:10.1177/0269881108089591. PMID   18515468. S2CID   206489666.
11. Zaidi SH, Faruqui RA (January 2008). "Aripiprazole is associated with early onset of Tardive Dyskinesia like presentation in a patient with ABI and psychosis". Brain Inj. 22 (1): 99–102. doi:10.1080/02699050701822493. PMID   18183513. S2CID   11197371.
12. Maytal G, Ostacher M, Stern TA (June 2006). "Aripiprazole-related tardive dyskinesia". CNS Spectr. 11 (6): 435–9. doi:10.1017/s1092852900014632. PMID   16816781. S2CID   41849016.
13. http://www.medicines.org.uk/EMC/pdfviewer.aspx?isAttachment=true&documentid=16161 ^{[ dead link ]}