List of adverse effects of ribavirin

List of adverse effects of ribavirin by frequency. ^{[1] [2] [3]}

Very common (>10% frequency)

• Abdominal pain
• Anemia
• Anxiety
• Appetite loss
• Concentration impaired
• Depression
• Diarrhea
• Dizziness
• Dry mouth
• Dry skin
• Emotional lability
• Fatigue
• Fever
• Hair loss
• Headache
• Influenza-like illness
• Insomnia
• Irritability
• Itchiness
• Joint aches and pains
• Muscle aches and pains
• Muscle weakness
• Musculoskeletal pain
• Nausea
• Neutropenia
• Rash
• Rigors
• Shortness of breath
• Viral pharyngitis
• Vomiting
• Weight loss

Common (1-10% frequency)

• Arthritis
• Back pain
• Cardiac murmur
• Chest discomfort
• Chest pain
• Dehydration
• Feeling abnormal
• Flushing
• Hemolytic anemia
• Hepatomegaly
• Hyperbilirubinemia
• Hyperglycemia
• Hypertension
• Hyperthyroidism
• Hyperuricemia
• Hypocalcemia
• Hypotension
• Hypothyroidism
• Increased appetite
• Jaundice
• Leukopenia
• Lymphadenopathy
• Lymphopenia
• Malaise
• Micturition frequency
• Muscle spasms
• Neoplasm formation
• Pain in extremity
• Palpitation
• Peripheral edema
• Polyuria
• Tachycardia
• Thirst
• Thrombocytopenia
• Urine abnormality

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• Gastrointestinal disturbances (including mouth ulcers, indigestion, diarrhea, constipation, etc.)
• Infections (including sinusitis, the flu, sepsis, UTIs, etc.)
• Neurologic disturbances (including memory loss, migraines, incoordination, sensory distortions, etc.)
• Psychiatric disturbances (including suicidal ideation and psychosis)
• Sexual disturbances (including erectile dysfunction, prostatis, amenorrhea, etc.)
• Skin disturbances (including acne, eczema, psoriasis, etc.)
• Upper respiratory tract disturbances (including nosebleeds, nasal/sinus congestion, etc.)
• Visual and hearing disturbances (including tinnitus, blurred vision, etc.)

Uncommon (0.1-1% frequency)

• Bone pain
• Diabetes mellitus
• Facial edema
• Heart attack
• Hypersensitivity
• Hypertriglyceridemia
• Immediately life-threatening psychiatric disturbances, including suicide attempts and hallucinations
• Mouth pain
• Neuropathy
• Pancreatitis

Rare (0.01-0.1% frequency)

• Arrhythmia
• Bipolar episode
• Cardiomyopathy
• Ischemic colitis
• Kidney failure or insufficiency
• Myositis
• Pneumonia
• Rhabdomyolysis
• Rheumatoid arthritis
• Sarcoidosis
• Seizures
• Serious eye complications
• Vasculitis

Very rare (<0.01% frequency)

• Aplastic anemia
• Cardiac ischemia
• Encephalopathy
• Erythema multiforme
• Life-threatening lung complications
• Liver failure
• Nephrotic syndrome
• Polyneuropathy
• Stevens–Johnson syndrome
• Stroke
• Suicide
• Toxic epidermal necrolysis
• Ulcerative colitis

Unknown frequency

• Anaphylaxis
• Angioedema
• Bronchoconstriction
• Facial palsy
• Hives
• Homicidal ideation
• Idiopathic thrombocytopenic purpura
• Mania
• Mental status change
• Mononeuropathies
• Pericardial effusion
• Pericarditis
• Periodontal disease
• Pure red cell aplasia
• Systemic lupus erythematosus
• Thrombotic thrombocytopenic purpura
• Vasculitis
• Vogt–Koyanagi–Harada disease

References

1. "PRODUCT INFORMATION REBETOL (RIBAVIRIN) CAPSULES" (PDF). TGA eBusiness Services. Merck Sharp & Dohme (Australia) Pty Limited. 29 April 2013. Retrieved 23 February 2014.
2. "COPEGUS (RIBAVIRIN) TABLET, FILM COATED [GENENTECH, INC]". DailyMed. Genentech, Inc. February 2013. Retrieved 23 February 2014.
3. "Rebetol 200mg hard capsules - Summary of Product Characteristics". Merck Sharp & Dohme Limited. 27 January 2014. Retrieved 23 February 2014.