![]() | |
Names | |
---|---|
Other names Maytansin | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.047.944 |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
| |
| |
Properties | |
C34H46ClN3O10 | |
Molar mass | 692.20 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. [1] The maytansine binding site and binding mode has been characterized. [2]
It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus . [1]
Derivatives of maitansine are known as maytansinoids. [3] [4] Some are being investigated as the cytotoxic component of antibody-drug conjugates for cancer treatment, [5] and the antibody-drug conjugate trastuzumab emtansine is an approved drug for the treatment of certain kinds of breast cancer in the EU and in the US. [6] [7]
Examples of maytansinoids are: