Manogepix

Last updated
Manogepix
Manogepix.svg
Clinical data
Other namesE1210, APX001A
ATC code
  • None
Identifiers
  • 3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C12H18N4O2
Molar mass 250.302 g·mol−1
3D model (JSmol)
  • c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N
  • InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
  • Key:WSEKTEUGRLFBSE-UHFFFAOYSA-N

Manogepix (E1210) is an pyridine-isoxazole-based broad-spectrum antifungal. [1] Manogepix targets an enzyme involved in the post-translational modification of fungal proteins.

Manogepix is the active metabolite of the prodrug fosmanogepix. [2]

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References

  1. Pfaller MA, Hata K, Jones RN, Messer SA, Moet GJ, Castanheira M (October 2011). "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease. 71 (2): 167–170. doi:10.1016/j.diagmicrobio.2011.05.001. PMID   21696907.
  2. Badali H, Patterson HP, Sanders CJ, Mermella B, Gibas CF, Ibrahim AS, et al. (May 2021). "Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes". Antimicrobial Agents and Chemotherapy. 65 (6). doi:10.1128/AAC.02343-20. PMC   8315997 . PMID   33722886.