Mississippi Highway 6 (MS 6) runs east–west from MS 161 in Lyon, east to MS 25 near Amory. It travels approximately 139 miles (224 km), serving Coahoma, Quitman, Panola, Lafayette, Pontotoc, Lee, and Monroe Counties. West of Tupelo, it is concurrent with US 278. Points of interest along the route include the University of Mississippi, Trace State Park, Natchez Trace Parkway, the Elvis Presley Birthplace, and Tombigbee State Park.
Mississippi Highway 12 is a state highway in northern Mississippi that runs 198.7 miles (319.8 km) west–east from MS 1 west of Hollandale at the Mississippi River to State Route 18 at the Alabama state line northeast of Columbus. MS 12 traverses three major regions of the state, the Mississippi Delta, the North Central Hills, and the Golden Triangle.
Mississippi Highway 50 is a state highway in Mississippi. It generally follows an east/west track for 60 miles (97 km) and runs from MS 9 in Walthall, Mississippi, east to the Alabama state line east of Columbus. MS 50 serves the following Mississippi counties: Lowndes, Clay, and Webster.
Mississippi Highway 30 is a state highway that runs across the North Central Hills of the Appalachian Mountains in northeast Mississippi. It travels east–west for 91.1 miles (146.6 km) from MS 7 at Oxford, Mississippi to the Natchez Trace Parkway in Mingo near the Alabama state line.
Mississippi Highway 4 runs east–west from an intersection in the community of Fox Island west of Tunica, Mississippi, near the border with Arkansas, to MS 25 in Tishomingo County, Mississippi. It travels a distance of 159.8 miles (257.2 km), serving Tunica, Tate, Marshall, Benton, Tippah, Prentiss, and Tishomingo Counties.
Mississippi Highway 3 is a north–south Mississippi state highway, located entirely within the Mississippi Delta region, running from Redwood to Lake Cormorant, both at an intersection with U.S. Route 61. For much of its duration, MS 3 is overlapped (concurrent) with U.S. Route 49W. It travels approximately 192 miles (309 km), serving DeSoto, Tunica, Tate, Panola, Quitman, Tallahatchie, Sunflower, Humphreys, Yazoo, and Warren counties.
Mississippi Highway 8 is an east–west state highway in northern Mississippi, running 168.1 miles (270.5 km) from MS 1 in Rosedale to U.S. Route 278 northeast of Aberdeen. Points of interest along the route include Great River Road State Park, Delta State University, Grenada Lake, Hugh White State Park, and the Natchez Trace Parkway.
Mississippi Highway 9 in the Appalachian Foothills region of northeastern Mississippi, running north–south from MS 30 east of New Albany to MS 12 in Ackerman. It runs approximately 116 miles (187 km), serving Choctaw, Webster, Calhoun, Pontotoc, and Union counties. MS 9W veers off to the left in a curve just about 2 miles north of Bruce. It goes north north-west until it merges with MS 7 just south of Oxford.
Mississippi Highway 43 is a state highway in Mississippi that generally runs north–south in three segments: the first from US 90 near Bay St. Louis to MS 13 south of Columbia, resuming at MS 13 in southern Jefferson Davis County to end near Mendenhall, and finally starting again at MS 18 near Puckett to end at Attala Road 3122 in northern Attala County. It traverses approximately 235 miles (378 km), serving Hancock, Pearl River, Marion, Jefferson Davis, Lawrence, Simpson, Rankin, Madison, Leake, and Attala counties.
Mississippi Highway 9W is a 20.3-mile (32.7 km) long state highway located in northern Mississippi. The southern terminus of the route is at MS 9 north of Bruce in Calhoun County while the northern terminus is at MS 7 south of Oxford in Lafayette County. The route is a two-lane undivided road its entire length and passes through rural areas of woods and farms. Along the way, MS 9W intersects MS 315 in Paris. MS 9W was designated to follow its current alignment in 1956 and was fully paved from a gravel road by 1960.
Mississippi Highway 35 is a state highway in Mississippi. It runs north–south for 274.7 miles (442.1 km), beginning at the Louisiana state line and ending at a junction with MS 315 at Sardis Dam. MS 35 serves the counties of Marion, Jefferson Davis, Covington, Smith, Scott, Leake, Attala, Carroll, Grenada, Tallahatchie, and Panola.
Mississippi Highway 26 is a state highway in southern Mississippi. It runs from west to east for 77.05 miles (124.00 km), serving the counties of Pearl River, Stone, and George.
Mississippi Highway 32 is a state highway in northern Mississippi it runs from east to west for 152.0 miles (244.6 km), serving the counties of Bolivar, Sunflower, Tallahatchie, Yalobusha, Calhoun, and Chickasaw. The publicly accessible portion of MS 32 is divided into two sections, the first of which begins near Perthshire and runs eastward to the rear entrance of the Mississippi State Penitentiary (MSP). The second section begins at the main entrance of MSP and runs eastward to MS 32's terminus in Okolona. A private portion of MS 32 runs from the main entrance of MSP to the rear entrance of MSP.
Mississippi Highway 22 is a state highway in central Mississippi, United States. It runs from east to west for approximately 43 miles (69 km), serving only two counties: Madison and Hinds, while connecting the towns of Edwards, Flora, and Canton.
Mississippi Highway 24 is a state highway in Mississippi, United States. The highway runs 76.0 miles (122.3 km) from Fort Adams east to an interchange with Interstate 55 (I-55) and U.S. Highway 98 in McComb. The roadway passes through Wilkinson, Amite, and Pike counties, serving the communities of Woodville, Centreville, Gloster, and Liberty. MS 24 has concurrencies with MS 33 between Centerville and Gloster and MS 48 from Liberty to west of McComb.
Mississippi Highway 41 (MS 41) is a state highway in northeastern Mississippi. The route starts at U.S. Route 45 and US 278 north of Wren and travels westwards. It then intersects US 45 Alt. east of Okolona. The road enters Okolona, and intersects MS 32 and MS 245. MS 41 then turns northwest and travels toward Pontotoc. Once inside the city, the route turns north at MS 15 and travels through downtown Pontotoc. MS 41 ends at its intersection with MS 9 and MS 338. The route that became MS 41 was first used as an Indian trail. The route was designated by 1932 from Amory to Pontotoc, and it was truncated from Amory to US 45 by 1955. The entirety of MS 41 was paved by 1958.
Mississippi Highway 403 is a state highway in central Mississippi. The route starts at U.S. Route 82 and MS 15 in Mathiston, and it travels north away from the town. It then turns east near Natchez Trace Parkway and then travels below it. MS 403 ends at the intersection of Clarkson Road and Old US 82 near a county highway maintenance barn. The route was designated by 1960, after a paved road extending from Mathiston was constructed around 1958. An extension northwards to MS 50 and MS 341 existed from 1960 to 1967.
Mississippi Highway 782 is a .218-mile-long (0.351 km) state highway located in the U.S. State of Mississippi. Located entirely within Mantee in Webster County, the western terminus of the route is at the western terminus of MS 46, where it continues as Main Street and the eastern terminus is at MS 15. Unlike most of the Mississippi Highways numbered between 701 and 992, MS 782 is signed.
Mississippi Highway 389 is a state highway that runs from south to north in the U.S. State of Mississippi. MS 389 currently exists in two sections. The southern section begins at MS 182 in Starkville. The road travels north out of the city, and crosses U.S. Route 82 and MS 15. North of Starkville, the route continues northwestwards and ends at the Oktibbeha–Clay county line south of Pheba. The northern section starts at MS 46 west of Montpelier, and it travels north to cross the Natchez Trace Parkway in Chickasaw County. MS 389 ends at MS 8 in Houston.
Mississippi Highway 467 is a short 15.1-mile-long (24.3 km) north-south highway located entirely in Hinds County in central Mississippi. It serves to connect the towns of Edwards and Raymond.
MS 50 west of West Point 
