Mouse brain development timeline

Last updated

The house mouse (Mus musculus) has a gestation period of 19 to 21 days. Key events in mouse brain development occur both before and after birth, beginning with peak neurogenesis of the cranial motor nuclei 9 days after conception, up to eye opening which occurs after birth and about 30 days after conception.

Contents

Stages in brain development

Days post conceptionEventReference
9cranial motor nuclei - peak of neurogenesis Finlay and Darlington (1995)
10 subplate -start of neurogenesisBayer and Altman (1991)
10inferior olivary nucleus - peak of neurogenesisFinlay and Darlington (1995)
10.5 retinal ganglion cell generation - start of neurogenesisRobinson and Dreher (1990)
10.5superficial superior colliculus (SC) laminae- start of neurogenesisRobinson and Dreher (1990)
10.5dorsal lateral geniculate nucleus (dLGN) - start of neurogenesisRobinson and Dreher (1990)
10.5 Purkinje cells - peak of neurogenesisFinlay and Darlington (1995)
11cranial sensory nuclei - peak of neurogenesisFinlay and Darlington (1995)
11subplate - peak of neurogenesisFinlay and Darlington (1995)
11reticular nuclei - peak of neurogenesisFinlay and Darlington (1995)
11 medial geniculate nucleus - peak of neurogenesisFinlay and Darlington (1995)
11 globus pallidus - peak of neurogenesisFinlay and Darlington (1995)
11.5ventral LGN - peak of neurogenesisFinlay and Darlington (1995)
12dLGN - peak of neurogenesisFinlay and Darlington (1995)
12 cochlear nuclei - peak of neurogenesisFinlay and Darlington (1995)
12 mitral cells - peak of neurogenesisFinlay and Darlington (1995)
12 amygdala - peak of neurogenesisFinlay and Darlington (1995)
12subplate - end of neurogenesisBayer and Altman (1991)
12.3axons in optic stalk Dunlop et al. (1997)
12.5 ventral posterior nucleus (VP) and ventrobasal nucleus (VB) of the thalamus - peak of neurogenesisFinlay and Darlington (1995)
12.5nucleus of lateral olfactory tract - peak of neurogenesisFinlay and Darlington (1995)
12.5 claustrum - peak of neurogenesisFinlay and Darlington (1995)
12.5neurogenesis cortical layer VI - peak (VC) of neurogenesisFinlay and Darlington (1995)
12.5dLGN- end of neurogenesisRobinson and Dreher (1990)
12.5 preoptic nucleus - peak of neurogenesisFinlay and Darlington (1995)
13 medial forebrain bundle appearsAshwell et al. (1996)
13 suprachiasmatic nucleus - peak of neurogenesisFinlay and Darlington (1995)
13optic axons at chiasm of optic tract Dunlop et al. (1997)
13 superior colliculus - peak of neurogenesisFinlay and Darlington (1995)
13retinal ganglion cells - peak of neurogenesisFinlay and Darlington (1995)
13 septal nuclei - peak of neurogenesisFinlay and Darlington (1995)
13 entorhinal cortex - peak of neurogenesisFinlay and Darlington (1995)
13 subiculum – peak of neurogenesisFinlay and Darlington (1995)
13neurogenesis cortical layer V - peak (VC) of neurogenesisFinlay and Darlington (1995)
13neurogenesis cortical lamina VI - end (VC) of neurogenesisCaviness (1982)
13.5raphe complex - peak of neurogenesisFinlay and Darlington (1995)
13.5 anterior olfactory nucleus - peak of neurogenesisFinlay and Darlington (1995)
13.5anteroventral (AV), anterodorsal (AD) and anteromedial (AM) thalamic nuclei - peak of neurogenesisFinlay and Darlington (1995)
13.5 pontine nuclei – peak of neurogenesisFinlay and Darlington (1995)
13.5 parasubiculum – peak of neurogenesisFinlay and Darlington (1995)
13.5 stria terminalis appearsAshwell et al. (1996)
13.5presubiculum – peak of neurogenesisFinlay and Darlington (1995)
14fasciculus retroflexus appearsFinlay and Darlington (1995)
14 caudoputamen – peak of neurogenesisFinlay and Darlington (1995)
14superficial SC laminae - end of neurogenesisRobinson and Dreher (1990)
14 fornix appearsAshwell et al. (1996)
14cones - peak of neurogenesisFinlay and Darlington (1995)
14neurogenesis cortical layer V - end (VC) of neurogenesisCaviness (1982)
14.5optic axons reach dLGN and SCRobinson and Dreher (1990)
14.5 anterior commissure appearsAshwell et al. (1996)
15neurogenesis cortical lamina IV - start (VC) of neurogenesisCaviness (1982)
15CA 1, CA 2 of hippocampus - peak of neurogenesisFinlay and Darlington (1995)
15retinal amacrine cells - peak of neurogenesisFinlay and Darlington (1995)
15 hippocampal commissure appearsAshwell et al. (1996)
15neurogenesis cortical layer II /III - peak (VC) of neurogenesisFinlay and Darlington (1995)
15.5optic axons invade visual centersDunlop et al. (1997)
16 nucleus accumbens - peak of neurogenesisFinlay and Darlington (1995)
16tufted cells - peak of neurogenesisFinlay and Darlington (1995)
16isles of Calleja - peak of neurogenesisFinlay and Darlington (1995)
17neurogenesis cortical layer IV - peak (VC) of neurogenesisCaviness (1982)
17 corpus callosum appearsAshwell et al. (1996)
17neurogenesis cortical layer IV - end (VC) of neurogenesisBayer and Altman (1991)
18.5 retinal ganglion cell generation - end of neurogenesisRobinson and Dreher (1990)
19initial differentiation of layer V (S1)Finlay and Darlington (1995)
19rods - peak of neurogenesisFinlay and Darlington (1995)
21complete separation of layer V (S1)Rice et al. (1985)
22onset of barrels (S1)Rice et al. (1985)
22onset of sublayers in layer V (S1)Rice et al. (1985)
22onset of trilaminar plate (S1)Rice et al. (1985)
24onset of barrel field septa (S1)Rice et al. (1985)
25.5ipsi/contra segregation in LGN and SCRobinson and Dreher (1990)
30 eye openingDunlop et al. (1997)

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References

See also