Myod family inhibitor domain containing

MDFIC
Identifiers
Aliases	MDFIC , HIC, MyoD family inhibitor domain containing, MDFIC1
External IDs	OMIM: 614511 MGI: 104611 HomoloGene: 18404 GeneCards: MDFIC
Gene location (Human)
Chr.	Chromosome 7 (human)
End	115,019,917 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	15,802,168 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; tibia; ; lactiferous duct; ; visceral pleura; ; germinal epithelium; ; periodontal fiber; ; cavity of mouth; ; superficial temporal artery; ; parietal pleura; ; palpebral conjunctiva;
	Top expressed in
	cumulus cell; ; ciliary body; ; iris; ; right lung lobe; ; conjunctival fornix; ; calvaria; ; sciatic nerve; ; left lung lobe; ; carotid body; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor binding ; Tat protein binding ; protein binding ; cyclin binding ;
Cellular component	nucleolus ; nucleus ; cytoplasm ; Golgi apparatus ; nucleoplasm ;
Biological process	positive regulation of transcription, DNA-templated ; positive regulation of viral transcription ; regulation of Wnt signaling pathway ; viral process ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; negative regulation of protein import into nucleus ; negative regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	29969
	16543
	ENSG00000135272
	ENSMUSG00000041390
	Q9P1T7
	Q8BX65
	NM_199072 ; NM_001166345 ; NM_001166346
	NM_175088
	NP_001159817 ; NP_001159818 ; NP_951038
	NP_780297
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. ^[5]

Function

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

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