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Ishmael "Ish" Taylor – A natural-born leader of African-American descent. He is hip, funny, smart, insightful, caring and brave. He loves video games and football and has a winning personality that endears him to his community. Ish was the very first Guardian, and lived in San Diego, California in the first season. In the second season, Season of the Guardians, Ish is now 11 years old, and living with his family in their new home of Canton, Ohio, and is captain of his local football team. With more training and experience than before, he is able to manifest a power armor with various abilities that consists of a football uniform and helmet via his new NFL-R watch with an inserted shield coin by shouting "Enter the Rush Zone!" and turning the dial. He is soon joined by a new team of Guardians with similar power armors, including his old friend Ash, and works together with them to protect the 32 Megacores from the evil Wild Card's clutches. In the second season finale, he sacrificed his Guardian powers to defeat Wild Card. His powers later returned and upgraded in the third season, Guardians Unleashed. His favorite team is the San Diego Chargers. He is voiced by Joshua Jackson in the first season, and Malachi Cohen in the second and third seasons.
Ashley "Ash" Reynolds – A tomboyish Caucasian redhead with freckles and green eyes, she is a good student and athlete. During the first season, she was under Sudden Death's spell, and only befriended Ish initially under his orders, but soon genuinely came to like him, and overcame Sudden Death's power to help Ish defeat him. In the second season, Ash is 11 years old, has reformed and is looking to redeem herself. She lost her mother a few years ago, and is now being raised by Charles Reynolds, her loving, and sometimes overprotective father. She is the brains of the group – complex plays or stats are easy for her. Her favorite team is the New England Patriots. She is voiced by Marisa Kreiss (daughter of head writer Nick Kreiss) in the first season, and by Sonic Boom Star Nika Futterman in the second and third seasons.
Troy Kang – A fun-loving and daring, slightly arrogant and hot-headed Korean-American 11-year-old boy who often leaps before he looks. But he is also incredibly loyal and dependable, especially when bravery is needed. Troy is a terrific athlete, but often he struggles to keep his grades up and is under constant pressure from his parents to do so. Being a Guardian teaches him to be a better team player, and someone who can share the spotlight and put the needs of others first. His favorite team is the New Orleans Saints. He is voiced by Power Rangers star Johnny Yong Bosch.
Tua Tupola – An 11-year-old Samoan-American from a family that is completely into football. He is the muscle and heart of the team. Because Tua is a boy of few words, people sometimes underestimate his intelligence, but he is actually very smart. He is warm, caring, insightful, thoughtful, and a straight shooter. He can be shy and a little insecure, but don't get him mad – he is a fierce fighter and a terrific football player. He is laid-back and easy-going, but being a Guardian teaches him the importance of practice and persistence. His favorite team is the Chicago Bears. He is voiced by Butt Ugly Martians Star Ogie Banks.
Martin "Marty" Stevens – An excitable fast-talking, Caucasian 11-year-old who is always ready to pull a prank, crack a joke, or defend his beloved Cleveland Browns. He is the class clown of the team, but also really smart, a good student, and handy with tech and computers. He has agility and moves like no other. When it comes time to fight, he can spin, twist, jump or dodge just about anything. His favorite team is the Cleveland Browns. He is voiced by Andy Aragon.
Ricardo "Ricky" Cervantes – A tough, competitive 11-year-old kid of Latino descent with an even tougher, more competitive dad. Ricky is rough on the outside and can be sarcastic and blunt. But he proves himself to be a loyal and dedicated friend and has something of a close bond with Ash. He started off as a rival towards Ish and was once under Wild Card's control, but now works with Ish and his friends as a Guardian. Ricky is the QB of the rival Youth Tackle Football team, the Tigers, and has amazing arm strength and firepower and can throw a football harder, faster and more accurately than just about anyone. His favorite team is the Arizona Cardinals. He is voiced by Nicolas Roye.
Villains
Sudden Death – In the first season, he planned on using the Core to take over the universe and hired Ash when she was rejected as the Guardian. He was destroyed at the end of season 1 during the final battle for the Core... but his final words to Ish were that they hadn't seen the last of him. This was later proven true after he returned in the third season, with a new plan to use the Megacores to either rule or destroy Earth. He is voiced by Matthew Mercer.
The Anticorians – Three alien humanoids who have sworn rivalry with Rusherz. They come to serve Sudden Death as their almighty leader in the third season.
- Angkoro – Obsequious, conniving and ruthless Anticorian. Uses telekinesis to levitate objects with his Antigravity power. Angkoro wants to be Sudden Death's number two, but is neither as strong nor as smart as his two colleagues, much to his dismay. He is voiced by Cam Clarke.
- Stellaria – Sleek, ninja-like Anticorian female. Smart, savvy, and athletic, she possesses the ability to conjure the power of wind to battle her enemy. She is voiced Nika Futterman.
- Zich – Large, brutish, strong, smart. Zich is both the technical brains and brawn behind the Anticorians. He speaks only in grunts but the Anticorians have no problem understanding him. His size is imposing. He is voiced by Liam O'Brien.
Wild Card – The main antagonist of the second season who wants to destroy the guardians and the NFL. He has a very short temper and hates losing more than anything. In the episode "The Mystery Guardian", it is revealed that Wild Card's true identity is Warren Zimmer, Richard Zimmer's (thus RZ's) son. He is finally defeated when his powers overloaded in the second season finale. He later returns as a supporting antagonist in the third season, when Sudden Death breaks him out of prison and forces him to work with him, but soon convinces Drop Kick, who had betrayed him the previous season to plot against Sudden Death and the Anticorians. After playing both sides in the third season finale, he escapes, vowing to eventually return. He is voiced by Troy Baker.
Drop Kick – Wild Card's mostly incompetent robot lackey, who is frequently the target of Wild Card's rage. In the episode "The Mystery Guardian", it is revealed that Drop Kick's true identity is Sidekick, also known as RZ 1.0, Richard Zimmer's robot assistant. Eventually, fed up with Wild Card's mistreatment of him, Drop Kick betrays his master near the end of the second season to try and take power for himself, but is defeated and destroyed by the Guardians. The Anticorians later rebuild him during the third season, but he is manipulated in to plotting against them and Sudden Death by Wild Card. He is destroyed once more in the season finale. He is voiced by Jesse Corti.
Allies
OT as RZ – The strange man who explains to Ish about the Core, the Rusherz, and Sudden Death. In the second season, he reveals himself as a supercomputer named RZ 6.0, telling Ish that "OT" was just one of many avatars he took to hide his true self. In the episode "The Mystery Guardian", it is revealed that he contains the essence of the scientist who made him, Richard Zimmer, as a result of an accident caused when Richard, with his son and his robot assistant performed an experiment with the power of the Core He is voiced by Liam O'Brien.
Shandra Taylor – Ish's mother. At first, she was clueless to the goings-on in regards to Ish's Guardian Status and was deeply puzzled by his newfound propensity to wander off, though she later found out. Soon after, OT warns her that, as the Guardian's parent, she would be a target for Sudden Death. In the second season, a few years after the defeat of Sudden Death, she and her husband, Lt. Matt Taylor, are aware of Ish's Guardian activities and have agreed to let Ish continue them. More than once has she has had to cover for her son's disappearances, and currently works as a tour guide at the Pro Football Hall of Fame.
Bolt – the Chargers Rusher, whom Ish met at the Chargers home game. He is a humanoid creature whose outfit consists of a white and blue football helmet with Chargers lightning bolts for a facemask and wears blue and yellow shorts with floral print. He was voiced by Zach Appelman.
The Gameballz – Ish's guardians in the first season:
- Huddle – a golden colored football with laces for a mouth who can speak Spanish.
- Fumble – A light salmon colored football with a green mohawk.
- Scream – A traditionally colored football with one eye, who is the more intelligent and tactical of the group.
- Additionally, Gameballz representing NFL teams appeared throughout the series.
BlitzBotz – Sudden Death's mechanical minions with one mission: collect the shards. They also have an arsenal of corruption footballs, which corrupt biological beings, transforming them into fellow BlitzBotz. 6 Rusherz had succumbed to this power, but were freed from it after Sudden Death's defeat.
