NOMO1

NOMO1
Identifiers
Aliases	NOMO1 , Nomo, PM5, NODAL modulator 1
External IDs	OMIM: 609157 MGI: 2385850 HomoloGene: 13810 GeneCards: NOMO1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.11 Start 14,833,721 bp [1] End 14,896,157 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 B3|7 29.66 cM Start 45,683,122 bp [2] End 45,733,636 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans superior frontal gyrus body of pancreas stromal cell of endometrium corpus callosum nucleus accumbens Brodmann area 9 Achilles tendon gastrocnemius muscle caudate nucleus Top expressed in otic placode saccule entorhinal cortex crypt of lieberkuhn of small intestine internal carotid artery blood external carotid artery lacrimal gland pyloric antrum right ventricle More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding molecular function Cellular component membrane integral component of membrane endoplasmic reticulum membrane Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23420 211548 Ensembl ENSG00000103512 ENSMUSG00000030835 UniProt Q15155 Q6GQT9 RefSeq (mRNA) NM_014287 NM_153057 RefSeq (protein) NP_055102 NP_694697 Location (UCSC) Chr 16: 14.83 – 14.9 Mb Chr 7: 45.68 – 45.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene. ^{[5] [6] [7]}

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103512 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030835 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Templeton NS, Rodgers LA, Levy AT, Ting KL, Krutzsch HC, Liotta LA, Stetler-Stevenson WG (Mar 1992). "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family". Genomics. 12 (1): 175–6. doi:10.1016/0888-7543(92)90425-R. PMID   1310294.
6. Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (Aug 2004). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMC   514924 . PMID   15257293.
7. "Entrez Gene: NOMO1 NODAL modulator 1".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID   15862967. S2CID   9746088.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi: 10.1038/nature03187 . PMID   15616553.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
• van Soest S, Swart J, Tijmes N, et al. (1997). "A Locus for Autosomal Recessive Pseudoxanthoma Elasticum, with Penetrance of Vascular Symptoms in Carriers, Maps to Chromosome 16p13.1". Genome Res. 7 (8): 830–4. doi:10.1101/gr.7.8.830. PMC   310666 . PMID   9267806.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID   8076819.