Nancy Hogg

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Nancy Hogg
Nancy Hogg.png
Known forStudy of Leukocyte Integrins
Scientific career
FieldsImmunology

Nancy Hogg FMedSci is an immunologist who has made major contributions in the field of adhesion molecules, focusing on the integrins expressed by leukocytes. [1] Hogg was elected to the Academy of Medical Sciences in 2002 and currently holds an emeritus position at the Francis Crick Institute, London.

Contents

Education and academic career

Nancy Hogg studied for a BSc at the University of Toronto. She was awarded a PhD working with Rodney Porter firstly at the University of London and then at Department of Biochemistry, University of Oxford. This was followed by a post–doctoral period at National Institute for Medical Research and finally a position at the Imperial Cancer Research Fund (which became Cancer Research UK London Research Institute and is now part of the Francis Crick Institute). Hogg was located initially at University College London followed by a move to the main laboratories in Lincoln’s Inn Fields where she set up her laboratory focusing initially on the function of macrophages, but then increasingly on the adhesion molecules termed integrins expressed by all leukocytes.

Research interests

Nancy Hogg’s PhD project involved the protein sequencing of immunoglobulin heavy chains identifying for the first time the heterogeneity that accounts for immunoglobulin specificity. [2] During a postdoctoral period at the Imperial Cancer Research Fund she co-discovered the protein that is now known as fibronectin. [3] Through study of leukocyte integrin LFA-1 and particularly special mAb 24, Hogg was the first to document that the state of integrin activity could be controlled by bound divalent cations. [4] [5] The active forms are linked to different cytoskeletal proteins, namely talin for high affinity and a-actinin for clustered intermediate affinity LFA-1 . [6] [7] The lab showed that the LFA-1 ligand ICAM-1 was a target for pathogen binding, for example the malaria parasite Plasmodium falciparum . [8] The generation of LFA-1 null mice revealed the central role of LFA-1 in leukocyte migration within lymph nodes in vivo. [9] [10] Hogg also first identified and characterised unique Leukocyte Adhesion Deficiency-III patients that expressed inactive leukocyte integrins. [11] This integrin malfunction was due to mutation in protein kindlin-3. [12]

Hogg has also studied the S100A8/S100A9 proteins that constitute 45% of neutrophil cytosolic protein. [13] [14] S100a9 null mice demonstrated that myeloid cells could function relatively normally without these proteins but they had a major role in responding to infections such as Streptococcus pneumoniae in terms of cytokine generation. [15]

Professional associations and awards

References

  1. 1 2 "Professor Nancy Hogg | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 16 February 2019.
  2. ↑ Press, E. M.; Hogg, N. M. (23 August 1969). "Comparative study of two immunoglobulin G Fd-fragments". Nature. 223 (5208): 808–810. Bibcode:1969Natur.223..807P. doi:10.1038/223807a0. ISSN   0028-0836. PMID   5799021. S2CID   4255320.
  3. ↑ Hogg, Nancy M. (February 1974). "A Comparison of Membrane Proteins of Normal and Transformed Cells by Lactoperoxidase Labeling". Proceedings of the National Academy of Sciences of the United States of America. 71 (2): 489–492. Bibcode:1974PNAS...71..489H. doi: 10.1073/pnas.71.2.489 . ISSN   0027-8424. PMC   388032 . PMID   4360946.
  4. ↑ Dransfield, I; Hogg, N (1 December 1989). "Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits". The EMBO Journal. 8 (12): 3759–3765. doi:10.1002/j.1460-2075.1989.tb08552.x. ISSN   0261-4189. PMC   402061 . PMID   2479549.
  5. ↑ Dransfield, I.; Cabañas, C.; Craig, A.; Hogg, N. (1 January 1992). "Divalent cation regulation of the function of the leukocyte integrin LFA-1". The Journal of Cell Biology. 116 (1): 219–226. doi:10.1083/jcb.116.1.219. ISSN   0021-9525. PMC   2289255 . PMID   1346139.
  6. ↑ Stanley, Paula; Smith, Andrew; McDowall, Alison; Nicol, Alastair; Zicha, Daniel; Hogg, Nancy (9 January 2008). "Intermediate-affinity LFA-1 binds α-actinin-1 to control migration at the leading edge of the T cell". The EMBO Journal. 27 (1): 62–75. doi:10.1038/sj.emboj.7601959. ISSN   0261-4189. PMC   2147999 . PMID   18079697.
  7. ↑ Smith, Andrew; Carrasco, Yolanda R.; Stanley, Paula; Kieffer, Nelly; Batista, Facundo D.; Hogg, Nancy (4 July 2005). "A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes". The Journal of Cell Biology. 170 (1): 141–151. doi:10.1083/jcb.200412032. ISSN   0021-9525. PMC   2171377 . PMID   15983060.
  8. ↑ Hogg, Nancy; Newbold, Christopher I.; Marsh, Kevin; Sternberg, Michael J. E.; Bates, Paul A.; Craig, Alister G.; McDowall, Alison; Berendt, Anthony R. (10 January 1992). "The binding site on ICAM-1 for plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site" . Cell. 68 (1): 71–81. doi:10.1016/0092-8674(92)90207-S. ISSN   0092-8674. PMID   1370656. S2CID   21267258.
  9. ↑ Berlin-Rufenach, Cornelia; Otto, Florian; Mathies, Meg; Westermann, Juergen; Owen, Michael J.; Hamann, Alf; Hogg, Nancy (3 May 1999). "Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice". The Journal of Experimental Medicine. 189 (9): 1467–1478. doi:10.1084/jem.189.9.1467. ISSN   0022-1007. PMC   2193056 . PMID   10224287.
  10. ↑ Reichardt, Peter; Patzak, Irene; Jones, Kristian; Etemire, Eloho; Gunzer, Matthias; Hogg, Nancy (20 March 2013). "A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes". The EMBO Journal. 32 (6): 829–843. doi:10.1038/emboj.2013.33. ISSN   0261-4189. PMC   3604724 . PMID   23443048.
  11. ↑ Hogg, Nancy; Stewart, Mairi P.; Scarth, Sarah L.; Newton, Rebecca; Shaw, Jacqueline M.; Law, S.K. Alex; Klein, Nigel (1 January 1999). "A novel leukocyte adhesion deficiency caused by expressed but nonfunctional β2 integrins Mac-1 and LFA-1". Journal of Clinical Investigation. 103 (1): 97–106. doi:10.1172/JCI3312. ISSN   0021-9738. PMC   407855 . PMID   9884339.
  12. ↑ Svensson, Lena; Howarth, Kimberley; McDowall, Alison; Patzak, Irene; Evans, Rachel; Ussar, Siegfried; Moser, Markus; Metin, Ayse; Fried, Mike (March 2009). "Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation". Nature Medicine. 15 (3): 306–312. doi:10.1038/nm.1931. ISSN   1078-8956. PMC   2680140 . PMID   19234463.
  13. ↑ Hogg, N.; Freemont, P.; Bennett, R.; Gorman, M.; Edgeworth, J. (25 April 1991). "Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells". Journal of Biological Chemistry. 266 (12): 7706–7713. doi: 10.1016/S0021-9258(20)89506-4 . ISSN   0021-9258. PMID   2019594.
  14. ↑ Hobbs, Josie A. R.; May, Richard; Tanousis, Kiki; McNeill, Eileen; Mathies, Margaret; Gebhardt, Christoffer; Henderson, Robert; Robinson, Matthew J.; Hogg, Nancy (April 2003). "Myeloid Cell Function in MRP-14 (S100A9) Null Mice". Molecular and Cellular Biology. 23 (7): 2564–2576. doi:10.1128/MCB.23.7.2564-2576.2003. ISSN   0270-7306. PMC   150714 . PMID   12640137.
  15. ↑ De Filippo, Katia; Neill, Daniel R.; Mathies, Meg; Bangert, Mathieu; McNeill, Eileen; Kadioglu, Aras; Hogg, Nancy (28 April 2014). "A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia". The FASEB Journal. 28 (8): 3600–3608. doi: 10.1096/fj.13-247460 . ISSN   0892-6638. PMID   24776746. S2CID   23158329.
  16. ↑ "British Society for Immunology |". www.immunology.org. Retrieved 16 February 2019.
  17. ↑ "ukcelladhesion" . Retrieved 16 February 2019.
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