Nicotianamine aminotransferase

Nicotianamine aminotransferase
Identifiers
EC no.	2.6.1.80
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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In enzymology, a nicotianamine aminotransferase (EC 2.6.1.80) is an enzyme that catalyzes the chemical reaction

nicotianamine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 3"-deamino-3"-oxonicotianamine + L-glutamate

Thus, the two substrates of this enzyme are nicotianamine and 2-oxoglutarate, whereas its two products are 3''-deamino-3''-oxonicotianamine and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is nicotianamine:2-oxoglutarate aminotransferase; nicotianamine transaminase. Other names in common use include NAAT, NAAT-I, NAAT-II, and NAAT-III.

References

• Mori S; Higuchi, Kyoko; Nishizawa, Naoko-Kishi; Fushiya, Shinji; Chino, Mitsuo; Mori, Satoshi (1994). "Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae". J. Exp. Bot. 45 (12): 1903–1906. doi:10.1093/jxb/45.12.1903.
• S; Yamaguchi, H; Nakanishi, H; Shioiri, T; Nishizawa, NK; Mori, S (1999). "Cloning Two Genes for Nicotianamine Aminotransferase, a Critical Enzyme in Iron Acquisition (Strategy II) in Graminaceous Plants". Plant Physiol. 121 (3): 947–56. doi:10.1104/pp.121.3.947. PMC   59459 . PMID   10557244.
• Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wiren N (2004). "ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals". J. Biol. Chem. 279 (10): 9091–6. doi: 10.1074/jbc.M311799200 . PMID   14699112.