U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee, just northeast of Johnson City. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
U.S. Route 276 is a United States highway that runs for 106.4 miles (171.2 km) from Mauldin, South Carolina to Cove Creek, North Carolina. It is known both as a busy urban highway in Greenville, South Carolina and a scenic back-road in Western North Carolina. Despite its numbering, it does not intersect its parent route U.S. Route 76.
U.S. Route 19W (US 19W) traverses approximately 63 miles (101 km) from Cane River, North Carolina, to Bluff City, Tennessee.
North Carolina Highway 75 (NC 75) is a primary state highway in the U.S. state of North Carolina. Its entire length runs through Union County and serves as the primary connector between the towns of Waxhaw, Mineral Springs, and Monroe. The route roughly parallels a CSX railroad line for its entire span.
North Carolina Highway 226 (NC 226) is a primary state highway in the U.S. state of North Carolina. Traveling north–south through Western North Carolina, it connects the cities and towns of Grover, Shelby, Marion, Spruce Pine and Bakersville. It also a scenic byway in the South Mountains area and connects with the summer colony of Little Switzerland, via NC 226A.
U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the Outer Banks. The route passes through the westernmost municipality in the state, Murphy, and one of the most easternmost municipalities, Manteo, making US 64 a symbolic representation of the phrase "from Murphy to Manteo" which is used to refer to the expanse of the state. The highway is a major east–west route through the central and eastern portion of the state.
North Carolina Highway 16 (NC 16) is a 143.8-mile primary state highway in the U.S. state of North Carolina. Traveling in a north–south direction, it connects the cities and towns of Charlotte, Newton, Conover, Taylorsville, Wilkesboro and Jefferson, linking the Charlotte metropolitan area with the mountainous High Country. NC 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
North Carolina Highway 11 is a primary state highway in the U.S. state of North Carolina. Traveling 193.2 miles (310.9 km) in a north–south alignment through Eastern North Carolina, it connects the towns and cities of Wallace, Kenansville, Kinston, Greenville and Murfreesboro.
North Carolina Highway 18 (NC 18) is a primary state highway in the U.S. state of North Carolina. Traveling north–south through the Foothills region, it connects the cities of Shelby, Morganton, Lenoir, Wilkesboro and North Wilkesboro.
North Carolina Highway 28 (NC 28) is an 81.2-mile-long (130.7 km) primary state highway in the U.S. state of North Carolina. The highway runs north–south through the Nantahala National Forest in Western North Carolina.
North Carolina Highway 62 (NC 62) is a primary state highway in the U.S. state of North Carolina. Primarily in the Piedmont Triad, it runs from NC 109 in Thomasville northeast to the Virginia state line in Milton.
North Carolina Highway 268 (NC 268) is a primary state highway in the U.S. state of North Carolina. It connects many communities as it traverses through the northwestern North Carolina mountains and foothills.
North Carolina Highway 115 is a primary state highway in the U.S. state of North Carolina. It runs from U.S. Route 21 in North Charlotte north through Mecklenburg, Iredell and Wilkes counties. Its northern terminus is at its intersection with US 421 Business, NC 18 and NC 268 in North Wilkesboro.
North Carolina Highway 197 is a South-to-North state highway in Western North Carolina. The route is approximately 58 miles (93 km) in length and with its continuation into Tennessee as SR 395 connects Erwin, Tennessee to Flat Creek, North Carolina. Portions of this highway lie within the Pisgah National Forest and is one of the few highways in the state with an unpaved portion.
North Carolina Highway 105 (NC 105) is a primary state highway in the U.S. state of North Carolina. It traverses from the mountain community of Linville to the town of Boone.
North Carolina Highway 175 (NC 175) is a primary state highway in the U.S. state of North Carolina. The highway runs north from the Georgia state line to US 64, along the eastern banks of Chatuge Lake.
North Carolina Highway 183 (NC 183) is a primary state highway in the U.S. state of North Carolina. It traverses from US 221, in the community of Linville Falls, to NC 181, near the community of Jonas Ridge.
North Carolina Highway 181 (NC 181) is a primary state highway in the U.S. state of North Carolina. It runs north–south from Morganton to Newland.
North Carolina Highway 194 (NC 194) is a primary state highway in the U.S. state of North Carolina. Entirely in the High Country, it runs from US 19E, in Ingalls, to the Virginia state line, near Helton.
North Carolina Highway 171 (NC 171) is a primary state highway in the U.S. state of North Carolina. It utilized as a connector route running from US 17 in Old Ford between Washington and Williamston to US 64 Business in Jamesville.
US 321 in Lenoir 
US 64 / NC 18 in Lenoir
I-40 in Statesville 
