Olga Vitek

Last updated

Olga Vitek
Alma mater Purdue University
Scientific career
Fields biostatistics, mass spectrometry, proteomics
Institutions Northeastern University
Thesis An inferential approach to protein backbone nuclear magnetic resonance assignment  (2005)
Doctoral advisor Bruce A. Craig and Chris Bailey-Kellogg

Olga Vitek is a biostatistician and computer scientist specializing in bioinformatics, proteomics, mass spectrometry, causal inference of biological function, and the development of open-source software for statistical analysis in these areas. She is a professor in the College of Science and Khoury College of Computer Sciences of Northeastern University.

Contents

Education and career

Vitek earned a bachelor's degree in econometrics and statistics from the University of Geneva in 1995, and a master's degree in 1996. She earned a second master's degree in mathematical statistics at Purdue University in 2001, and completed her PhD at Purdue in 2005. [1] As a graduate student, she interned with Eli Lilly and Company; [2] her 2005 doctoral dissertation, An Inferential Approach to Protein Backbone Nuclear Magnetic Resonance Assignment, [3] was jointly supervised by statistician Bruce A. Craig and computer scientist Chris Bailey-Kellogg. [4]

After postdoctoral research with Ruedi Aebersold at the Institute for Systems Biology in Seattle, Vitek joined the Purdue University faculty in 2006, [4] with a joint appointment in the departments of statistics and computer science. She moved to Northeastern University in 2014, where she held the title of Sy and Laurie Sternberg Interdisciplinary Associate Professor before being promoted to full professor. [2]

She serves as council member for the Human Proteome Organization, [5] board of director for the US Human Proteome Organization, [6] and president of the American Statistical Association Boston Chapter. [7] She is a founding committee member of Computational Mass Spectrometry (CompMS). [8] She is an editorial board member of Molecular and Cellular Proteomics , [9] and associate editor of Bioinformatics . [10]

Research

Vitek's research contributions include work with David E. Salt at Purdue University on genetic adaptations allowing plants to tolerate salt, [11] and a study debunking earlier claims that some programming languages cause their users to write buggier code than other languages. [12] She leads the project MSstats with Meena Choi and the project Cardinal with Kylie Bemis to develop open-sourced statistical software for mass spectrometry analyses, funded by the Essential Open Source Software for Science program of the Chan Zuckerberg Initiative. [13]

Recognition

Vitek was named a Fellow of the American Statistical Association in 2021. [14] She received the Gilbert S. Omenn Computational Proteomics Award from the US Human Proteome Organization, [15] and the Indigo BioAutomation FeMS Distinguished Contribution Award in 2021. [16]

Related Research Articles

<span class="mw-page-title-main">Proteomics</span> Large-scale study of proteins

Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body.

Mass spectrometry is a scientific technique for measuring the mass-to-charge ratio of ions. It is often coupled to chromatographic techniques such as gas- or liquid chromatography and has found widespread adoption in the fields of analytical chemistry and biochemistry where it can be used to identify and characterize small molecules and proteins (proteomics). The large volume of data produced in a typical mass spectrometry experiment requires that computers be used for data storage and processing. Over the years, different manufacturers of mass spectrometers have developed various proprietary data formats for handling such data which makes it difficult for academic scientists to directly manipulate their data. To address this limitation, several open, XML-based data formats have recently been developed by the Trans-Proteomic Pipeline at the Institute for Systems Biology to facilitate data manipulation and innovation in the public sector. These data formats are described here.

The Association of Biomolecular Resource Facilities (ABRF) is dedicated to advancing core and research biotechnology laboratories through research, communication, and education. ABRF members include over 2000 scientists representing 340 different core laboratories in 41 countries, including those in industry, government, academic and research institutions.

<span class="mw-page-title-main">Ruedi Aebersold</span> Swiss biologist (born 1954)

Rudolf Aebersold is a Swiss biologist, regarded as a pioneer in the fields of proteomics and systems biology. He has primarily researched techniques for measuring proteins in complex samples, in many cases via mass spectrometry. Ruedi Aebersold is a professor of Systems biology at the Institute of Molecular Systems Biology (IMSB) in ETH Zurich. He was one of the founders of the Institute for Systems Biology in Seattle, Washington, where he previously had a research group.

The Proteomics Standards Initiative (PSI) is a working group of the Human Proteome Organization. It aims to define data standards for proteomics to facilitate data comparison, exchange and verification.

<i>Molecular & Cellular Proteomics</i> Academic journal

Molecular & Cellular Proteomics is a monthly peer-reviewed scientific journal established in 2002 and published by the American Society for Biochemistry and Molecular Biology. It covers research on structural and functional properties of proteins, especially with regard to development.

<span class="mw-page-title-main">Pavel A. Pevzner</span> Russian-born American professor of computational mass spectrometry

Pavel Arkadevich Pevzner is the Ronald R. Taylor Professor of Computer Science and Director of the NIH Center for Computational Mass Spectrometry at University of California, San Diego. He serves on the Editorial Board of PLoS Computational Biology and he is a member of the Genome Institute of Singapore scientific advisory board.

Richard Dale Smith is a chemist and a Battelle Fellow and Chief Scientist within the Biological Sciences Division, as well as the Director of Proteomics Research at the Pacific Northwest National Laboratory (PNNL). Dr. Smith is also Director of the NIH Proteomics Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho and the Department of Molecular Microbiology & Immunology, Oregon Health & Science University. He is the author or co-author of approximately 1100 peer-reviewed publications and has been awarded 70 US patents.

<span class="mw-page-title-main">Catherine Clarke Fenselau</span> American scientist

Catherine Clarke Fenselau is an American scientist who was the first trained mass spectrometrist on the faculty of an American medical school; she joined Johns Hopkins School of Medicine in 1968. She specializes in biomedical applications of mass spectrometry. She has been recognized as an outstanding scientist in the field of bioanalytical chemistry because of her work using mass spectrometry to study biomolecules.

<span class="mw-page-title-main">Ronald Beavis</span> Canadian protein biochemist

Ronald Charles Beavis is a Canadian protein biochemist, who has been involved in the application of mass spectrometry to protein primary structure, with applications in the fields of proteomics and analytical biochemistry. He has developed methods for measuring the identity and post-translational modification state of proteins obtained from biological samples using mass spectrometry. He is currently best known for developing new methods for analyzing proteomics data and applying the results of these methods to problems in computational biology.

Zeng Rong is a Chinese biochemist researching and developing technology for proteomics research. She is currently a professor at the Institute of Biochemistry and Cell Biology at the Shanghai Institutes for Biological Sciences.

David Fenyö is a Swedish-American physicist and mass spectrometrist. He is currently professor in the Department of Biochemistry and Molecular Pharmacology at NYU Langone Medical Center. Fenyö's research focuses on the development of methods to identify, characterize and quantify proteins and in the integration of data from multiple modalities including mass spectrometry, sequencing and microscopy.

Ying Ge is a Chinese-American biologist who is a Professor of Cell and Regenerative Biology at the University of Wisconsin–Madison. Her research considers the molecular mechanisms that underpin cardiac disease. She has previously served on the board of directors of the American Society for Mass Spectrometry. In 2020 Ge was named on the Analytical Scientist Power List.

Catherine E. Costello is the William Fairfield Warren distinguished professor in the Department of Biochemistry, Cell Biology and Genomics, and the director of the Center for Biomedical Mass Spectrometry at the Boston University School of Medicine.

Jennifer Eileen Van Eyk is the Erika Glazer Chair in Women's Heart Health, the Director of Advanced Clinical Biosystems Institute in the Department of Biomedical Sciences, the Director of Basic Science Research in the Women's Heart Center, a Professor in Medicine and in Biomedical Sciences at Cedars-Sinai. She is a renowned scientist in the field of clinical proteomics.

Lingjun Li is a Professor in the School of Pharmacy and Department of Chemistry at University of Wisconsin-Madison. She develops mass spectrometry based tools to study neuropeptides, peptide hormones and neurotransmitters.

Amanda Grace Paulovich is an oncologist, and a pioneer in proteomics using multiple reaction monitoring mass spectrometry to study tailored cancer treatment.

Yu-Ju Chen (陳玉如) is a Taiwanese proteomics research scientist, who leads international projects in proteogenomics.

References

  1. ↑ "Olga Vitek", People, Purdue University Department of Statistics, retrieved 2021-07-04
  2. 1 2 "Olga Vitek", People, Khoury College of Computer Sciences, retrieved 2021-07-04
  3. ↑ Olga Vitek at the Mathematics Genealogy Project
  4. 1 2 Alexandrov, Theodore (November 2013), "Leading a statistical bioinformatics lab: it's all about finding balance", PLOS Computational Biology (Interview with Olga Vitek), 9 (11): e1003333, Bibcode:2013PLSCB...9E3333V, doi:10.1371/journal.pcbi.1003333, PMC   3820503 , PMID   24244141
  5. ↑ "HUPO - Governance". www.hupo.org. Retrieved 2023-01-15.
  6. ↑ "US HUPO - Board of Directors". www.ushupo.org. Retrieved 2023-01-15.
  7. ↑ "ASA Boston Chapter Current Officers". ASA Community. Retrieved 2023-01-15.
  8. ↑ "About | Computational Mass Spectrometry". compms.org. Retrieved 2023-01-15.
  9. ↑ "MCP Editorial Board". apps.asbmb.org. Retrieved 2023-01-15.
  10. ↑ "Editorial Board". Bioinformatics. Retrieved 2023-01-15.
  11. ↑ "Plants can adapt genetically to survive harsh environments", ScienceDaily, 31 January 2011
  12. ↑ Claburn, Thomas (30 January 2019), "Boffins debunk study claiming certain languages (cough, C, PHP, JS...) lead to more buggy code than others", The Register
  13. ↑ "MSstats and Cardinal: Next Generation Statistical Mass Spectrometry in R". Chan Zuckerberg Initiative. Retrieved 2023-01-15.
  14. ↑ ASA Fellows list, American Statistical Association, retrieved 2021-07-04
  15. ↑ "US HUPO - Computational Proteomics Award". www.ushupo.org. Retrieved 2022-06-11.
  16. ↑ "Indigo BioAutomation FeMS Awards". Females in Mass Spectrometry. 5 November 2021. Retrieved 2022-12-25.
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