Oxford Nanopore Technologies

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Oxford Nanopore Technologies plc
Company type Public limited company
LSE:  ONT
ISIN GB00BP6S8Z30
Industry Nanopore sequencing
Founded2005;20 years ago (2005)
Founders
Headquarters,
Key people
  • Duncan Tatton-Brown (Chair)
  • Gordon Sanghera (CEO)
RevenueIncrease2.svg £183.2 million (2024) [1]
Increase2.svg £(152.3) million (2024) [1]
Increase2.svg £(146.2) million (2024) [1]
Website nanoporetech.com

Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore sequencing products (including the portable DNA sequencer, MinION) for the direct, electronic analysis of single molecules. [2] [3] [4] It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index. [5]

Contents

History

The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley, [6] Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group. [7] The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT. [8]

In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel). [9] The company stated in a webcast that R9 is designed to improve error rates and yield. [10]

American astronaut Kate Rubins with a MinION sequencer on the ISS in August 2016. First-ever sequencing of DNA in space, performed by Kate Rubins on the ISS. 128f0462 sequencer 1.jpg
American astronaut Kate Rubins with a MinION sequencer on the ISS in August 2016.

In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station. [11] The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment. [12] During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth. [13] Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications. [14]

Products

Top view of a closed Oxford Nanopore Technologies MinION sequencer showing how it is small enough to be held in one hand Oxford Nanopore MinION top cropped.jpg
Top view of a closed Oxford Nanopore Technologies MinION sequencer showing how it is small enough to be held in one hand

The main products of Oxford Nanopore are:

These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research. [3] [28]

References

  1. 1 2 3 "Annual Results for year ended 31 December 2024" (PDF). Oxford Nanopore Technologies. Retrieved 4 March 2025.
  2. ↑ Eisenstein, M. (2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology . 30 (4): 295–6. doi:10.1038/nbt0412-295. PMID   22491260. S2CID   205267199.
  3. 1 2 3 Mikheyev, A. S.; Tin, M. M. Y. (2014). "A first look at the Oxford Nanopore MinION sequencer". Molecular Ecology Resources. 14 (6): 1097–102. Bibcode:2014MolER..14.1097M. doi:10.1111/1755-0998.12324. PMID   25187008. S2CID   3674911.
  4. ↑ Loman, N. J.; Quinlan, A. R. (2014). "Poretools: A toolkit for analyzing nanopore sequence data". Bioinformatics. 30 (23): 3399–401. doi:10.1093/bioinformatics/btu555. PMC   4296151 . PMID   25143291.
  5. ↑ "FTSE UK Index Series Quarterly Review December 2024". FTSE Russell. 4 December 2024. Retrieved 20 December 2024.
  6. ↑ "BAYLEY, Prof. (John) Hagan (Pryce)" . Who's Who . Vol. 2015 (online edition via Oxford University Press  ed.). A & C Black.(Subscription or UK public library membership required.)
  7. ↑ "DNA sequencing: The hole story". The Economist. London. 16 October 2008. Retrieved 19 October 2014.
  8. ↑ "London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market". 11 October 2021.
  9. ↑ "VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore" . Retrieved 9 May 2016.
  10. ↑ "No thanks, I've already got one". YouTube . 8 March 2016. Retrieved 9 May 2016.
  11. ↑ Ramsey, Sarah (21 June 2016). "Next SpaceX Commercial Cargo Launch Now No Earlier Than July 18" . Retrieved 25 July 2016.
  12. ↑ "Sequencing DNA in Space - SpaceRef". spaceref.com. Retrieved 25 July 2016.
  13. ↑ Rainey, Kristine (29 August 2016). "First DNA Sequencing in Space a Game Changer". NASA. Retrieved 17 October 2016.
  14. ↑ McIntyre, Alexa B. R.; Rizzardi, Lindsay; Yu, Angela M.; Rosen, Gail L.; Alexander, Noah; Botkin, Douglas J.; John, Kristen K.; Castro-Wallace, Sarah L.; Burton, Aaron S. (10 December 2015). "Nanopore Sequencing in Microgravity". bioRxiv   10.1101/032342 .
  15. ↑ Check Hayden, E. (2014). "Data from pocket-sized genome sequencer unveiled". Nature. doi: 10.1038/nature.2014.14724 .
  16. ↑ Check Hayden, E. (2015). "Pint-sized DNA sequencer impresses first users". Nature. 521 (7550): 15–6. Bibcode:2015Natur.521...15C. doi: 10.1038/521015a . PMID   25951262.
  17. ↑ "IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC". Archived from the original on 21 November 2015. Retrieved 20 November 2015.
  18. ↑ Loman, Nicholas J; Watson, Mick (2015). "Successful test launch for nanopore sequencing". Nature Methods. 12 (4): 303–304. doi:10.1038/nmeth.3327. ISSN   1548-7091. PMID   25825834. S2CID   5604121.
  19. ↑ "Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements". GenomeWeb. Retrieved 6 July 2017.
  20. ↑ "GridION X5". nanoporetech.com. Retrieved 6 July 2017.
  21. ↑ "Community - Oxford Nanopore Technologies". Archived from the original on 27 June 2015. Retrieved 17 June 2015.
  22. ↑ "Specifications - Community - Oxford Nanopore Technologies". Archived from the original on 1 June 2016. Retrieved 20 November 2015.
  23. ↑ "Oxford Nanopore CTO Clive Brown's Talk at London Calling: MinION ASIC, volTRAX, promethION". Next Gen Seek. 14 May 2015.
  24. ↑ "VolTRAX". nanoporetech.com. Retrieved 17 October 2016.
  25. ↑ "Oxford Nanopore: we want to create the internet of living things". Wired UK.
  26. ↑ "Metrichor". metrichor.com. Retrieved 17 August 2016.
  27. ↑ "SmidgION - Products & services - Oxford Nanopore Technologies". www2.nanoporetech.com. Archived from the original on 23 August 2016. Retrieved 17 August 2016.
  28. ↑ Check Hayden, Erika (2012). "Nanopore genome sequencer makes its debut". Nature. doi: 10.1038/nature.2012.10051 . ISSN   1744-7933.