Oxford Nanopore Technologies

Last updated

Oxford Nanopore Technologies plc
Company type Public limited company
LSE:  ONT
ISIN GB00BP6S8Z30
Industry Nanopore sequencing
Founded2005;20 years ago (2005)
Founders
Headquarters,
Key people
  • Duncan Tatton-Brown (Chair)
  • Gordon Sanghera (CEO)
RevenueIncrease2.svg £183.2 million (2024) [1]
Increase2.svg £(152.3) million (2024) [1]
Increase2.svg £(146.2) million (2024) [1]
Website nanoporetech.com

Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore sequencing products (including the portable DNA sequencer, MinION) for the direct, electronic analysis of single molecules. [2] [3] [4] It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index. [5]

Contents

History

The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley, [6] Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group. [7] The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT. [8]

In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel). [9] The company stated in a webcast that R9 is designed to improve error rates and yield. [10]

American astronaut Kate Rubins with a MinION sequencer on the ISS in August 2016. First-ever sequencing of DNA in space, performed by Kate Rubins on the ISS. 128f0462 sequencer 1.jpg
American astronaut Kate Rubins with a MinION sequencer on the ISS in August 2016.

In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station. [11] The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment. [12] During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth. [13] Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications. [14]

Products

Top view of a closed Oxford Nanopore Technologies MinION sequencer showing how it is small enough to be held in one hand Oxford Nanopore MinION top cropped.jpg
Top view of a closed Oxford Nanopore Technologies MinION sequencer showing how it is small enough to be held in one hand

The main products of Oxford Nanopore are:

These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research. [3] [28]

References

  1. 1 2 3 "Annual Results for year ended 31 December 2024" (PDF). Oxford Nanopore Technologies. Retrieved 4 March 2025.
  2. Eisenstein, M. (2012). "Oxford Nanopore announcement sets sequencing sector abuzz". Nature Biotechnology . 30 (4): 295–6. doi:10.1038/nbt0412-295. PMID   22491260. S2CID   205267199.
  3. 1 2 3 Mikheyev, A. S.; Tin, M. M. Y. (2014). "A first look at the Oxford Nanopore MinION sequencer". Molecular Ecology Resources. 14 (6): 1097–102. Bibcode:2014MolER..14.1097M. doi:10.1111/1755-0998.12324. PMID   25187008. S2CID   3674911.
  4. Loman, N. J.; Quinlan, A. R. (2014). "Poretools: A toolkit for analyzing nanopore sequence data". Bioinformatics. 30 (23): 3399–401. doi:10.1093/bioinformatics/btu555. PMC   4296151 . PMID   25143291.
  5. "FTSE UK Index Series Quarterly Review December 2024". FTSE Russell. 4 December 2024. Retrieved 20 December 2024.
  6. "BAYLEY, Prof. (John) Hagan (Pryce)" . Who's Who . Vol. 2015 (online edition via Oxford University Press  ed.). A & C Black.(Subscription or UK public library membership required.)
  7. "DNA sequencing: The hole story". The Economist. London. 16 October 2008. Retrieved 19 October 2014.
  8. "London Stock Exchange welcomes Oxford Nanopore Technologies plc to the Main Market". 11 October 2021.
  9. "VIB announces collaboration with Oxford Nanopore Technologies on new DNA sequencing nanopore" . Retrieved 9 May 2016.
  10. "No thanks, I've already got one". YouTube . 8 March 2016. Retrieved 9 May 2016.
  11. Ramsey, Sarah (21 June 2016). "Next SpaceX Commercial Cargo Launch Now No Earlier Than July 18" . Retrieved 25 July 2016.
  12. "Sequencing DNA in Space - SpaceRef". spaceref.com. Retrieved 25 July 2016.
  13. Rainey, Kristine (29 August 2016). "First DNA Sequencing in Space a Game Changer". NASA. Retrieved 17 October 2016.
  14. McIntyre, Alexa B. R.; Rizzardi, Lindsay; Yu, Angela M.; Rosen, Gail L.; Alexander, Noah; Botkin, Douglas J.; John, Kristen K.; Castro-Wallace, Sarah L.; Burton, Aaron S. (10 December 2015). "Nanopore Sequencing in Microgravity". bioRxiv   10.1101/032342 .
  15. Check Hayden, E. (2014). "Data from pocket-sized genome sequencer unveiled". Nature. doi: 10.1038/nature.2014.14724 .
  16. Check Hayden, E. (2015). "Pint-sized DNA sequencer impresses first users". Nature. 521 (7550): 15–6. Bibcode:2015Natur.521...15C. doi: 10.1038/521015a . PMID   25951262.
  17. "IP Group PLC – Portfolio company Oxford Nanopore announces £70m fundraising – IP Group PLC". Archived from the original on 21 November 2015. Retrieved 20 November 2015.
  18. Loman, Nicholas J; Watson, Mick (2015). "Successful test launch for nanopore sequencing". Nature Methods. 12 (4): 303–304. doi:10.1038/nmeth.3327. ISSN   1548-7091. PMID   25825834. S2CID   5604121.
  19. "Oxford Nanopore Launches GridIon X5 Nanopore Sequencer, Details Product Improvements". GenomeWeb. Retrieved 6 July 2017.
  20. "GridION X5". nanoporetech.com. Retrieved 6 July 2017.
  21. "Community - Oxford Nanopore Technologies". Archived from the original on 27 June 2015. Retrieved 17 June 2015.
  22. "Specifications - Community - Oxford Nanopore Technologies". Archived from the original on 1 June 2016. Retrieved 20 November 2015.
  23. "Oxford Nanopore CTO Clive Brown's Talk at London Calling: MinION ASIC, volTRAX, promethION". Next Gen Seek. 14 May 2015.
  24. "VolTRAX". nanoporetech.com. Retrieved 17 October 2016.
  25. "Oxford Nanopore: we want to create the internet of living things". Wired UK.
  26. "Metrichor". metrichor.com. Retrieved 17 August 2016.
  27. "SmidgION - Products & services - Oxford Nanopore Technologies". www2.nanoporetech.com. Archived from the original on 23 August 2016. Retrieved 17 August 2016.
  28. Check Hayden, Erika (2012). "Nanopore genome sequencer makes its debut". Nature. doi: 10.1038/nature.2012.10051 . ISSN   1744-7933.