Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. [5] [6]
This gene encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene. [6]
Loss of function mutations in PDCD10 result in the onset of Cerebral Cavernous Malformations (CCM) illness. [5] Therefore, this gene is also called CCM3. Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and spinal cord made of dilated capillary vessels.
CCM3 encodes a protein called Programmed Cell Death 10 (PDCD10). The function of this protein has only recently begun to be understood. PDCD10 has roles in vascular development and VEGF signaling1, [7] apoptosis [8] and functions as part of a larger signaling complex that includes germinal center kinase III. [9] [10] Specifically, PDCD10 has been shown to interact with RP6-213H19.1, [11] STK25, [11] [12] STRN, [11] STRN3, [11] MOBKL3, [11] CTTNBP2NL, [11] STK24 [11] [12] [13] and FAM40A. [11]