STRN

STRN
Identifiers
Aliases	STRN , SG2NA, PPP2R6A, striatin, STRN1
External IDs	OMIM: 614765; MGI: 1333757; HomoloGene: 2380; GeneCards: STRN; OMA:STRN - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p22.2 Start 36,837,698 bp [1] End 36,966,536 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E3 Start 78,957,342 bp [2] End 79,044,625 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell amniotic fluid corpus callosum gingival epithelium Achilles tendon oral cavity inferior ganglion of vagus nerve germinal epithelium subthalamic nucleus epithelium of colon Top expressed in zygote secondary oocyte primary oocyte dorsal striatum olfactory tubercle nucleus accumbens cumulus cell substantia nigra superior frontal gyrus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 2A binding estrogen receptor binding protein binding calmodulin binding armadillo repeat domain binding protein-containing complex binding Cellular component cytoplasm soma postsynaptic membrane dendritic spine protein phosphatase type 2A complex cell projection membrane postsynaptic density bicellular tight junction dendrite FAR/SIN/STRIPAK complex Biological process dendrite development Wnt signaling pathway locomotory behavior negative regulation of cell population proliferation bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6801 268980 Ensembl ENSG00000115808 ENSMUSG00000024077 UniProt O43815 O55106 RefSeq (mRNA) NM_003162 NM_011500 RefSeq (protein) NP_003153 NP_035630 Location (UCSC) Chr 2: 36.84 – 36.97 Mb Chr 17: 78.96 – 79.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Striatin is a protein that in humans is encoded by the STRN gene. ^{[5] [6] [7]}

Interactions

STRN has been shown to interact with:

• CTTNBP2NL, ^[8]
• CTTNBP2, ^[8]
• FAM40A, ^[8]
• MOBKL3, ^[8]
• PDCD10, ^[8]
• PPP2CA, ^[8]
• PPP2R1A, ^[8]
• RP6-213H19.1, ^[8]
• STK24, ^{[8] [9]}
• STK25, ^[8]
• STRN3, ^[8] and
• TRAF3IP3. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000115808 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024077 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID   9693043.
6. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC   2120968 . PMID   8769426.
7. "Entrez Gene: STRN striatin, calmodulin binding protein".
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Feb 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". The Journal of Biological Chemistry. 275 (8): 5257–63. doi: 10.1074/jbc.275.8.5257 . PMC   3505218 . PMID   10681496.
• Gaillard S, Bartoli M, Castets F, Monneron A (Nov 2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Letters. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID   11707266. S2CID   7887096.
• Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues". Molecular Biology Reports. 28 (4): 185–91. doi:10.1023/A:1015726217890. PMID   12153137. S2CID   9167130.
• Hwang J, Pallas DC (February 2014). "STRIPAK complexes: structure, biological function, and involvement in human diseases". The International Journal of Biochemistry & Cell Biology. 47: 118–48. doi:10.1016/j.biocel.2013.11.021. PMC   3927685 . PMID   24333164.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH (Dec 2004). "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha". Proceedings of the National Academy of Sciences of the United States of America. 101 (49): 17126–31. Bibcode:2004PNAS..10117126L. doi: 10.1073/pnas.0407492101 . PMC   534607 . PMID   15569929.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.