STRN

STRN
Identifiers
Aliases	STRN , SG2NA, PPP2R6A, striatin, STRN1
External IDs	OMIM: 614765 MGI: 1333757 HomoloGene: 2380 GeneCards: STRN
Gene location (Human)
Chr.	Chromosome 2 (human)
End	36,966,536 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	79,044,625 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; corpus callosum; ; Achilles tendon; ; cavity of mouth; ; inferior ganglion of vagus nerve; ; germinal epithelium; ; subthalamic nucleus; ; Brodmann area 23; ; parietal pleura;
	Top expressed in
	secondary oocyte; ; olfactory tubercle; ; nucleus accumbens; ; cumulus cell; ; substantia nigra; ; superior frontal gyrus; ; globus pallidus; ; ciliary body; ; hair follicle; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding ; estrogen receptor binding ; protein binding ; calmodulin binding ; armadillo repeat domain binding ; protein-containing complex binding ;
Cellular component	cytoplasm ; neuronal cell body ; postsynaptic membrane ; dendritic spine ; protein phosphatase type 2A complex ; cell projection ; membrane ; postsynaptic density ; bicellular tight junction ; dendrite ; FAR/SIN/STRIPAK complex ;
Biological process	dendrite development ; Wnt signaling pathway ; locomotory behavior ; negative regulation of cell population proliferation ; bicellular tight junction assembly ;
	Sources:Amigo / QuickGO
Orthologs
	6801
	268980
	ENSG00000115808
	ENSMUSG00000024077
	O43815
	O55106
	NM_003162
	NM_011500
	NP_003153
	NP_035630
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Striatin is a protein that in humans is encoded by the STRN gene.^[5]^[6]^[7]

Interactions

STRN has been shown to interact with:

Related Research Articles

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.

DNA-directed RNA polymerase I subunit RPA49 is an enzyme that in humans is encoded by the POLR1E gene.

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.

Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene.

Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene.

Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene.

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.

Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the MOBKL3 gene.

MOB kinase activator 1A is an enzyme that in humans is encoded by the MOB1A gene.

Striatin-3 is a protein that in humans is encoded by the STRN3 gene.

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.

Sarcolemmal membrane-associated protein is a protein that in humans is encoded by the SLMAP gene.

Protein FAM40A is a protein that is located on chromosome 1 in humans and is encoded by the FAM40A gene.

Serine/threonine-protein phosphatase 4 regulatory subunit 1 is an enzyme that in humans is encoded by the PPP4R1 gene.

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.

Striatin-4 is a protein that in humans is encoded by the STRN4 gene.

Actin-related protein 3B also known as ARP3-beta is a protein that in humans is encoded by the ACTR3B gene. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115808 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024077 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.
↑ Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968 . PMID 8769426.
↑ "Entrez Gene: STRN striatin, calmodulin binding protein".
1 2 3 4 5 6 7 8 9 10 11 12 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Feb 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". The Journal of Biological Chemistry. 275 (8): 5257–63. doi: 10.1074/jbc.275.8.5257 . PMC 3505218 . PMID 10681496.
Gaillard S, Bartoli M, Castets F, Monneron A (Nov 2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Letters. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. S2CID 7887096.
Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues". Molecular Biology Reports. 28 (4): 185–91. doi:10.1023/A:1015726217890. PMID 12153137. S2CID 9167130.
Hwang J, Pallas DC (February 2014). "STRIPAK complexes: structure, biological function, and involvement in human diseases". The International Journal of Biochemistry & Cell Biology. 47: 118–48. doi:10.1016/j.biocel.2013.11.021. PMC 3927685 . PMID 24333164.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH (Dec 2004). "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha". Proceedings of the National Academy of Sciences of the United States of America. 101 (49): 17126–31. Bibcode:2004PNAS..10117126L. doi: 10.1073/pnas.0407492101 . PMC 534607 . PMID 15569929.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115808 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024077 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693043-5] Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.

[pmid8769426-6] Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968 . PMID 8769426.

[entrez-7] "Entrez Gene: STRN striatin, calmodulin binding protein".

[pmid18782753-8] 1 2 3 4 5 6 7 8 9 10 11 12 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004 . PMID 18782753.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

STRN

Contents

Interactions

Related Research Articles

References

Further reading