CTTNBP2

CTTNBP2
Identifiers
Aliases	CTTNBP2 , C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDs	OMIM: 609772 MGI: 1353467 HomoloGene: 14125 GeneCards: CTTNBP2
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q31.31 Start 117,710,651 bp [1] End 117,874,139 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 A2 Start 18,366,477 bp [2] End 18,514,842 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ganglionic eminence subthalamic nucleus inferior ganglion of vagus nerve endothelial cell external globus pallidus medulla oblongata germinal epithelium caudate nucleus putamen Top expressed in subiculum lateral geniculate nucleus piriform cortex medial geniculate nucleus superior cervical ganglion medial dorsal nucleus olfactory tubercle visual cortex habenula nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding Cellular component cytoplasm dendritic spine cell projection cell cortex synaptic vesicle postsynaptic actin cytoskeleton glutamatergic synapse Biological process brain development regulation of synapse organization regulation of modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83992 30785 Ensembl ENSG00000077063 ENSMUSG00000000416 UniProt Q8WZ74 B9EJA2 RefSeq (mRNA) NM_033427 NM_001363349 NM_001363350 NM_001363351 NM_080285 RefSeq (protein) NP_219499 NP_001350278 NP_001350279 NP_001350280 NP_525024 Location (UCSC) Chr 7: 117.71 – 117.87 Mb Chr 6: 18.37 – 18.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene. ^{[5] [6]}

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton. ^[6]

Interactions

CTTNBP2 has been shown to interact with:

• MOBKL3, ^[7]
• PPP2CA, ^[7]
• RP6-213H19.1, ^[7]
• STRN3, ^[7] and
• STRN. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000077063 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000416 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID   11707066.
6. "Entrez Gene: CTTNBP2 cortactin binding protein 2".
7. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC   2621004 . PMID   18782753.

External links

• Human CTTNBP2 genome location and CTTNBP2 gene details page in the UCSC Genome Browser .

Further reading

• Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells. 3 (9): 603–12. doi: 10.1046/j.1365-2443.1998.00216.x . PMID   9813110. S2CID   22413036.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
• Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei". J. Cell Biol. 166 (6): 815–25. doi:10.1083/jcb.200404107. PMC   2172106 . PMID   15364959.