STRN3

STRN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N6J
Identifiers
Aliases	STRN3 , SG2NA, PPP2R6B, striatin 3, S/G2NA
External IDs	OMIM: 614766; MGI: 2151064; HomoloGene: 82078; GeneCards: STRN3; OMA:STRN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q12 Start 30,893,799 bp [1] End 31,026,401 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 B3 Start 51,656,415 bp [2] End 51,738,680 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon biceps brachii sural nerve Skeletal muscle tissue of biceps brachii testicle tail of epididymis Skeletal muscle tissue of rectus abdominis gastrocnemius muscle muscle of thigh Top expressed in interventricular septum triceps brachii muscle temporal muscle ankle muscle of thigh medial head of gastrocnemius muscle intercostal muscle sternocleidomastoid muscle digastric muscle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein phosphatase 2A binding protein binding calmodulin binding armadillo repeat domain binding protein-containing complex binding Cellular component cytoplasm soma plasma membrane Golgi apparatus dendrite protein phosphatase type 2A complex membrane nucleus nucleoplasm protein-containing complex FAR/SIN/STRIPAK complex Biological process response to estradiol negative regulation of intracellular estrogen receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29966 94186 Ensembl ENSG00000196792 ENSMUSG00000020954 UniProt Q13033 Q9ERG2 RefSeq (mRNA) NM_001083893 NM_014574 NM_001172098 NM_052973 NM_001364437 RefSeq (protein) NP_001077362 NP_055389 NP_001165569 NP_443205 NP_001351366 Location (UCSC) Chr 14: 30.89 – 31.03 Mb Chr 12: 51.66 – 51.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Striatin-3 is a protein that in humans is encoded by the STRN3 gene. ^{[5] [6] [7]}

Interactions

STRN3 has been shown to interact with:

• CTTNBP2NL, ^[8]
• CTTNBP2, ^[8]
• FAM40A, ^[8]
• MOBKL3, ^[8]
• PDCD10, ^[8]
• PPP2CA, ^[8]
• PPP2R1A, ^[8]
• RP6-213H19.1, ^[8]
• STK24, ^{[8] [9]} and
• STRN. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000196792 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020954 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Muro Y, Chan EK, Landberg G, Tan EM (Mar 1995). "A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells". Biochem. Biophys. Res. Commun. 207 (3): 1029–37. doi:10.1006/bbrc.1995.1288. PMID   7864889.
6. Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Mar 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi: 10.1074/jbc.275.8.5257 . PMC   3505218 . PMID   10681496.
7. "Entrez Gene: STRN3 striatin, calmodulin binding protein 3".
8. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi: 10.1074/mcp.M800266-MCP200 . PMC   2621004 . PMID   18782753.
9. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

Further reading

• Landberg G, Tan EM (1994). "Characterization of a DNA-binding nuclear autoantigen mainly associated with S phase and G2 cells". Exp. Cell Res. 212 (2): 255–61. doi:10.1006/excr.1994.1141. PMID   7910562.
• Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi: 10.1074/jbc.M909782199 . PMID   10748158.
• Moreno CS, Lane WS, Pallas DC (2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". J. Biol. Chem. 276 (26): 24253–60. doi: 10.1074/jbc.M102398200 . PMC   3503316 . PMID   11319234.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID   16396496.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.