Periapical granuloma

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Periapical granuloma, [1] also sometimes referred to as a radicular granuloma or apical granuloma, is an inflammation at the tip of a dead (nonvital) tooth. It is a lesion or mass that typically starts out as an epithelial lined cyst, and undergoes an inward curvature that results in inflammation of granulation tissue at the root tips of a dead tooth. This is usually due to dental caries or a bacterial infection of the dental pulp. Periapical granuloma is an infrequent disorder that has an occurrence rate between 9.3 to 87.1 percent. [2] Periapical granuloma is not a true granuloma due to the fact that it does not contain granulomatous inflammation; however, periapical granuloma is a common term used. [3]

Contents

Symptoms

Patients who have a periapical granuloma are usually asymptomatic; however, when there is inflammation, patients could experience temperature sensitivity, pain while chewing solid foods, swelling and sensitivity to a dental percussion test. [4] [ better source needed ]

Generally, periapical granuloma is diagnosed due to acute pain in a tooth, or during a radiographic examination in routine visits to the dentist. [5] [ better source needed ]

Radiographic Features

When looking at the radiographic features of periapical granuloma, typically there is a radiolucent lesion visible at the tip of a root on a nonvital tooth. This often is associated with root resorption. The radiolucency must correlate with the lateral root surface or the root of the tooth. [1]

The average size of radiography when looking at periapical granuloma is 7.4 millimeters (mm). [6] [ non-primary source needed ]

Histopathology

When examining the tissues of periapical granuloma for disease, hyperaemia, oedema and chronic inflammation is observed in the periodontal ligament. The vascular amplification and inflammation is adjacent to the bone, and bone absorption occurs next to a large growth in fibroblast and endothelial cells which is composed of the small fibers (fibrils) with small vascular conduits (channels of passage for fluids).[ citation needed ]

The lesion is predominantly composed of plasma cells that are mixed with macrophages and lymphocytes with endothelial cells and fibroblasts. [7]

Treatment

Treatment for periapical granuloma is initially treated with a nonsurgical procedure. Endodontic treatments of teeth with periapical lesions (lesions that occurred as a result of dental pulp inflammation) have a success rate up to 85 percent. [8] [ non-primary source needed ] Other forms of nonsurgical treatments used for periapical lesions are: a root canal, an aspiration-irrigation technique (a technique to help minimize the force required for the removal of root canal irrigant); [9] [ non-primary source needed ] a decompression technique (a minimally invasive surgery that involves the placement of tubing to help maintain drainage); [10] Lesion Sterilization and Repair Therapy (a technique that allows disinfection of pulpal (dental pulp), dentinal (dentin) and periradicular (around a root) lesions by using a combination of antibacterial drugs;[ citation needed ] a method using calcium hydroxide and the Apexum procedure (a minimally invasive removal, through a root canal access, of periapical chronically inflamed tissue).[ citation needed ] It is essential to monitor the healing closely after treatment with frequent follow-up examinations. If nonsurgical techniques fail, surgical intervention is then recommended.[ citation needed ]

There are many things to be considered prior to surgical treatment in order to decide which technique will have the best outcome. When determining an approach for surgical approaches, clinicians must establish the correct diagnosis of the lesion to make sure there isn’t treatment being done on healthy (vital) teeth. It is also important to take into consideration the distance (proximity) of the lesion to the vital teeth. If the lesion is in close proximity to the roots of vital teeth, a surgical approach may have negative outcomes that include the blood vessels and nerves of the adjacent teeth being injured, this of which would jeopardize their vitality (life). Surgical approaches increase the risk of the anatomic structures being damaged. Some of these anatomic structures include: the nasal cavity, mental foramen, the inferior alveolar nerve and / or the inferior alveolar artery and the maxillary sinus. When sinus cavities or adjacent tissue spaces are involved, the nonsurgical aspiration-irrigation technique is also not advised. The patient’s cooperation and age of the patient are very important as well. Patients may experience pain or discomfort during or after treatment when taking the surgical approach which could make them uncooperative. Patients that are older may not be able to tolerate this pain or discomfort, therefore they may require nonsurgical approaches. If access to the apical foramen is prevented due to blockages in the root canal system, a surgical approach may be warranted. Finally, surgery is recommended in cases where patients have the presence of cholesterol crystals or inflammatory apical true cysts (the top of an enclosed space lined by the epithelium and usually contains fluid) [11] due to the fact that these can prevent the healing of the lesions. [2]

See also

Related Research Articles

<span class="mw-page-title-main">Endodontics</span> Field of dentistry

Endodontics is the dental specialty concerned with the study and treatment of the dental pulp.

<span class="mw-page-title-main">Toothache</span> Medical condition of the teeth

Toothache, also known as dental pain or tooth pain, is pain in the teeth or their supporting structures, caused by dental diseases or pain referred to the teeth by non-dental diseases. When severe it may impact sleep, eating, and other daily activities.

<span class="mw-page-title-main">Pulp (tooth)</span> Part in the center of a tooth made up of living connective tissue and cells called odontoblasts

The pulp is the connective tissue, nerves, blood vessels, and odontoblasts that comprise the innermost layer of a tooth. The pulp's activity and signalling processes regulate its behaviour.

A pulp polyp, also known as chronic hyperplastic pulpitis, is a "productive" inflammation of dental pulp in which the development of granulation tissue is seen in response to persistent, low-grade mechanical irritation and bacterial invasion of the pulp.

Dens invaginatus (DI), also known as tooth within a tooth, is a rare dental malformation where there is an infolding of enamel into dentine. The prevalence of condition is 0.3 - 10%, affecting more males than females. The condition is presented in two forms, coronal and radicular, with the coronal form being more common.

<span class="mw-page-title-main">Dentin dysplasia</span> Medical condition

Dentin dysplasia (DD) is a rare genetic developmental disorder affecting dentine production of the teeth, commonly exhibiting an autosomal dominant inheritance that causes malformation of the root. It affects both primary and permanent dentitions in approximately 1 in every 100,000 patients. It is characterized by the presence of normal enamel but atypical dentin with abnormal pulpal morphology. Witkop in 1972 classified DD into two types which are Type I (DD-1) is the radicular type, and type II (DD-2) is the coronal type. DD-1 has been further divided into 4 different subtypes (DD-1a,1b,1c,1d) based on the radiographic features.

<span class="mw-page-title-main">Periapical cyst</span> Medical condition

Commonly known as a dental cyst, the periapical cyst is the most common odontogenic cyst. It may develop rapidly from a periapical granuloma, as a consequence of untreated chronic periapical periodontitis.

<span class="mw-page-title-main">Dental abscess</span> Medical condition

A dental abscess is a localized collection of pus associated with a tooth. The most common type of dental abscess is a periapical abscess, and the second most common is a periodontal abscess. In a periapical abscess, usually the origin is a bacterial infection that has accumulated in the soft, often dead, pulp of the tooth. This can be caused by tooth decay, broken teeth or extensive periodontal disease. A failed root canal treatment may also create a similar abscess.

<span class="mw-page-title-main">Dental radiography</span> X-ray imaging in dentistry

Dental radiographs, commonly known as X-rays, are radiographs used to diagnose hidden dental structures, malignant or benign masses, bone loss, and cavities.

<span class="mw-page-title-main">Root canal treatment</span> Dental treatment

Root canal treatment is a treatment sequence for the infected pulp of a tooth which is intended to result in the elimination of infection and the protection of the decontaminated tooth from future microbial invasion. Root canals, and their associated pulp chamber, are the physical hollows within a tooth that are naturally inhabited by nerve tissue, blood vessels and other cellular entities. Together, these items constitute the dental pulp.

Apical periodontitis is typically the body's defense response to the threat of microbial invasion from the root canal. Primary among the members of the host defense mechanism is the polymorphonuclear leukocyte, otherwise known as the neutrophil. The task of the neutrophil is to locate and destroy microbes that intrude into the body – anywhere in the body – and they represent the hallmark of acute inflammation.

<span class="mw-page-title-main">Pulpotomy</span>

Pulpotomy is a minimally invasive procedure performed in children on a primary tooth with extensive caries but without evidence of root pathology. The minimally invasive endodontic techniques of vital pulp therapy (VPT) are based on improved understanding of the capacity of pulp (nerve) tissues to heal and regenerate plus the availability of advanced endodontic materials. During the caries removal, this results in a carious or mechanical pulp exposure (bleeding) from the cavity. During pulpotomy, the inflamed/diseased pulp tissue is removed from the coronal pulp chamber of the tooth leaving healthy pulp tissue which is dressed with a long-term clinically successful medicament that maintains the survival of the pulp and promotes repair. There are various types of medicament placed above the vital pulp such as Buckley's Solution of formocresol, ferric sulfate, calcium hydroxide or mineral trioxide aggregate (MTA). MTA is a more recent material used for pulpotomies with a high rate of success, better than formocresol or ferric sulfate. It is also recommended to be the preferred pulpotomy agent in the future. After the coronal pulp chamber is filled, the tooth is restored with a filling material that seals the tooth from microleakage, such as a stainless steel crown which is the most effective long-term restoration. However, if there is sufficient remaining supporting tooth structure, other filling materials such as amalgam or composite resin can provide a functional alternative when the primary tooth has a life span of two years or less. The medium- to long-term treatment outcomes of pulpotomy in symptomatic permanent teeth with caries, especially in young people, indicate that pulpotomy can be a potential alternative to root canal therapy (RCT).

<span class="mw-page-title-main">Tooth resorption</span> Medical condition

Resorption of the root of the tooth, or root resorption, is the progressive loss of dentin and cementum by the action of odontoclasts. Root resorption is a normal physiological process that occurs in the exfoliation of the primary dentition. However, pathological root resorption occurs in the permanent or secondary dentition and sometimes in the primary dentition.

Combined periodontic-endodontic lesions are localized, circumscribed areas of bacterial infection originating from either dental pulp, periodontal tissues surrounding the involved tooth or teeth or both.

Pulp necrosis is a clinical diagnostic category indicating the death of cells and tissues in the pulp chamber of a tooth with or without bacterial invasion. It is often the result of many cases of dental trauma, caries and irreversible pulpitis.

A phoenix abscess is an acute exacerbation of a chronic periapical lesion. It is a dental abscess that can occur immediately following root canal treatment. Another cause is due to untreated necrotic pulp. It is also the result of inadequate debridement during the endodontic procedure. Risk of occurrence of a phoenix abscess is minimised by correct identification and instrumentation of the entire root canal, ensuring no missed anatomy.

A cyst is a pathological epithelial lined cavity that fills with fluid or soft material and usually grows from internal pressure generated by fluid being drawn into the cavity from osmosis. The bones of the jaws, the mandible and maxilla, are the bones with the highest prevalence of cysts in the human body. This is due to the abundant amount of epithelial remnants that can be left in the bones of the jaws. The enamel of teeth is formed from ectoderm, and so remnants of epithelium can be left in the bone during odontogenesis. The bones of the jaws develop from embryologic processes which fuse, and ectodermal tissue may be trapped along the lines of this fusion. This "resting" epithelium is usually dormant or undergoes atrophy, but, when stimulated, may form a cyst. The reasons why resting epithelium may proliferate and undergo cystic transformation are generally unknown, but inflammation is thought to be a major factor. The high prevalence of tooth impactions and dental infections that occur in the bones of the jaws is also significant to explain why cysts are more common at these sites.

<span class="mw-page-title-main">Periapical periodontitis</span> Medical condition

Periapical periodontitis or apical periodontitis (AP) is an acute or chronic inflammatory lesion around the apex of a tooth root, most commonly caused by bacterial invasion of the pulp of the tooth. It is a likely outcome of untreated dental caries, and in such cases it can be considered a sequela in the natural history of tooth decay, irreversible pulpitis and pulpal necrosis. Other causes can include occlusal trauma due to 'high spots' after restoration work, extrusion from the tooth of root filling material, or bacterial invasion and infection from the gums. Periapical periodontitis may develop into a periapical abscess, where a collection of pus forms at the end of the root, the consequence of spread of infection from the tooth pulp, or into a periapical cyst, where an epithelial lined, fluid-filled structure forms.

<span class="mw-page-title-main">Regenerative endodontics</span> Dental specialty

Regenerative endodontic procedures is defined as biologically based procedures designed to replace damaged structures such as dentin, root structures, and cells of the pulp-dentin complex. This new treatment modality aims to promote normal function of the pulp. It has become an alternative to heal apical periodontitis. Regenerative endodontics is the extension of root canal therapy. Conventional root canal therapy cleans and fills the pulp chamber with biologically inert material after destruction of the pulp due to dental caries, congenital deformity or trauma. Regenerative endodontics instead seeks to replace live tissue in the pulp chamber. The ultimate goal of regenerative endodontic procedures is to regenerate the tissues and the normal function of the dentin-pulp complex.

In the dental specialty of endodontics, periradicular surgery is surgery to the external root surface. Examples of periradicular surgery include apicoectomy, root resection, repair of root perforation or resorption defects, removal of broken fragments of the tooth or a filling material, and exploratory surgery to look for root fractures.

References

  1. 1 2 Flucke U, Thompson LD (2019). "Non-Neoplastic Lesions of the Gnathic Bones". Head and Neck Pathology (Third ed.). W.B. Saunders. pp. 363–382. doi:10.1016/b978-1-4377-2607-7.00022-1. ISBN   9781437726077.
  2. 1 2 Fernandes M, de Ataide I (October 2010). "Nonsurgical management of periapical lesions". Journal of Conservative Dentistry. 13 (4): 240–5. doi: 10.4103/0972-0707.73384 . PMC   3010029 . PMID   21217952.
  3. Neville BW, Damm DD, Allen CA, Bouquot JE (2002). Oral & maxillofacial pathology (2nd ed.). Philadelphia: W.B. Saunders. pp.  113–124. ISBN   978-0721690032.
  4. Bahcall, J. "A Clinician's Guide to Clinical Endodontics : Percussion Tests for Determining the Status of the Periodontal Ligament". p. 6.
  5. Cleveland Clinic. (2017, January 26). Acute Pain vs. Chronic Pain. Retrieved from https://my.clevelandclinic.org/health/articles/12051-acute-vs-chronic-pain
  6. Farhadi F, Mirinezhad SS, Zarandi A (2016). "Using Periapical Radiography to Differentiate Periapical Granuloma and Radicular Cysts". Avicenna Journal of Dental Research. 8 (2): 7. doi: 10.17795/ajdr-30882 . Archived from the original on 2018-04-10.
  7. "Periapical granuloma". World Health Organization.
  8. Akinyamoju AO, Gbadebo SO, Adeyemi BF (December 2014). "Periapical lesions of the jaws: a review of 104 cases in ibadan". Annals of Ibadan Postgraduate Medicine. 12 (2): 115–9. PMC   4415388 . PMID   25960702.
  9. Fukumoto Y (March 2005). "[Intracanal aspiration technique for root canal irrigation: evaluation of smear layer removal]". Kokubyo Gakkai Zasshi. The Journal of the Stomatological Society, Japan. 72 (1): 13–8. doi:10.5357/koubyou.71and72.13. PMID   15856767.
  10. Fernandes M, De Ataide I (June 2010). "Non-surgical management of a large periapical lesion using a simple aspiration technique: a case report". International Endodontic Journal. 43 (6): 536–42. doi:10.1111/j.1365-2591.2010.01719.x. PMID   20536582.
  11. Holm N (August 27, 2018). "Cutaneous Columnar Cysts". Medscape.