Pocapavir

Last updated
Pocapavir
Pocapavir structure.png
Clinical data
Other namesV-073
Identifiers
  • 1,3-dichloro-2-{[4-[(2-chloro-4-methoxyphenoxy)methyl]phenyl]methoxy}benzene
CAS Number
PubChem CID
DrugBank
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C21H17Cl3O3
Molar mass 423.71 g·mol−1
3D model (JSmol)
  • COC1=CC(=C(C=C1)OCC2=CC=C(C=C2)COC3=C(C=CC=C3Cl)Cl)Cl
  • InChI=1S/C21H17Cl3O3/c1-25-16-9-10-20(19(24)11-16)26-12-14-5-7-15(8-6-14)13-27-21-17(22)3-2-4-18(21)23/h2-11H,12-13H2,1H3
  • Key:XXMDDBVNWRWNCW-UHFFFAOYSA-N

Pocapavir (V-073, SCH48973) is an antiviral drug which acts as a capsid inhibitor. It was developed for the treatment of enterovirus infections, including diseases such as polio and coxsackievirus, and also has activity against parechoviruses. [1] [2] [3] [4] [5] [6] [7] [8] [9]

See also

References

  1. ↑ Lentz KN, Smith AD, Geisler SC, Cox S, Buontempo P, Skelton A, DeMartino J, Rozhon E, Schwartz J, Girijavallabhan V, O'Connell J, Arnold E (July 1997). "Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes". Structure. 5 (7): 961–978. doi: 10.1016/s0969-2126(97)00249-9 . PMID   9261087.
  2. ↑ De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J (April 2008). "Potential use of antiviral agents in polio eradication". Emerging Infectious Diseases. 14 (4): 545–551. doi:10.3201/eid1404.070439. PMC   2570929 . PMID   18394270.
  3. ↑ McKinlay MA, Collett MS, Hincks JR, Oberste MS, Pallansch MA, Okayasu H, Sutter RW, Modlin JF, Dowdle WR (November 2014). "Progress in the development of poliovirus antiviral agents and their essential role in reducing risks that threaten eradication". The Journal of Infectious Diseases. 210: S447 –S453. doi:10.1093/infdis/jiu043. PMID   25316866.
  4. ↑ Torres-Torres S, Myers AL, Klatte JM, Rhoden EE, Oberste MS, Collett MS, McCulloh RJ (January 2015). "First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis". The Pediatric Infectious Disease Journal. 34 (1): 52–54. doi:10.1097/INF.0000000000000497. PMID   25229269.
  5. ↑ Collett MS, Hincks JR, Benschop K, Duizer E, van der Avoort H, Rhoden E, Liu H, Oberste MS, McKinlay MA, Hartford M (February 2017). "Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model". The Journal of Infectious Diseases. 215 (3): 335–343. doi:10.1093/infdis/jiw542. PMC   5393058 . PMID   27932608.
  6. ↑ Harik N, DeBiasi RL (April 2018). "Neonatal nonpolio enterovirus and parechovirus infections". Seminars in Perinatology. 42 (3): 191–197. doi:10.1053/j.semperi.2018.02.007. PMID   29526382.
  7. ↑ Copelyn J, Hincks JR, Wilmshurst JM, Petersen W, Howard W, Jallow S, Moonsamy S, Seakamela L, Suchard M, Collett MS, Eley B (May 2020). "Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir". The Pediatric Infectious Disease Journal. 39 (5): 435–437. doi:10.1097/INF.0000000000002584. PMID   32150007.
  8. ↑ Kankam MK, Burns JM, Collett MS, Corrado ML, Hincks JR (September 2021). "A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers". Antimicrobial Agents and Chemotherapy. 65 (10): e0102921. doi:10.1128/AAC.01029-21. PMC   8448163 . PMID   34370575.
  9. ↑ Tomatis Souverbielle C, Erdem G, Sánchez PJ (June 2023). "Update on nonpolio enterovirus and parechovirus infections in neonates and young infants". Current Opinion in Pediatrics. 35 (3): 380–389. doi:10.1097/MOP.0000000000001236. PMID   36876331.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.