RGS7

RGS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2A72, 2D9J
Identifiers
Aliases	RGS7 , regulator of G protein signaling 7
External IDs	OMIM: 602517; MGI: 1346089; HomoloGene: 2193; GeneCards: RGS7; OMA:RGS7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q43|1q23.1 Start 240,767,636 bp [1] End 241,357,374 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 81.11 cM Start 174,886,653 bp [2] End 175,320,066 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus frontal pole Region I of hippocampus proper orbitofrontal cortex Brodmann area 46 Brodmann area 10 primary visual cortex paraflocculus of cerebellum Top expressed in facial motor nucleus primary visual cortex dentate gyrus of hippocampal formation granule cell Cortex of frontal lobe superior frontal gyrus prefrontal cortex temporal lobe primary motor cortex cingulate gyrus amygdala More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein beta-subunit binding GTPase activator activity GTPase activity Cellular component cytosol membrane cytoplasm plasma membrane heterotrimeric G-protein complex Biological process G protein-coupled receptor signaling pathway positive regulation of GTPase activity negative regulation of signal transduction intracellular signal transduction protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6000 24012 Ensembl ENSG00000182901 ENSMUSG00000026527 UniProt P49802 O54829 RefSeq (mRNA) NM_001282773 NM_001282775 NM_001282778 NM_002924 NM_001350113 NM_001350114 NM_001350115 NM_001350116 NM_001364886 NM_001374806 NM_001374807 NM_001374808 NM_001374809 NM_001374810 NM_001374811 NM_001374812 NM_001374813 NM_001374814 NM_001374815 NM_001374816 NM_001199003 NM_011880 NM_001347195 NM_001357129 RefSeq (protein) NP_001269702 NP_001269704 NP_001269707 NP_002915 NP_001337042 NP_001337043 NP_001337044 NP_001337045 NP_001351815 NP_001361735 NP_001361736 NP_001361737 NP_001361738 NP_001361739 NP_001361740 NP_001361741 NP_001361742 NP_001361743 NP_001361744 NP_001361745 NP_001185932 NP_001334124 NP_036010 NP_001344058 Location (UCSC) Chr 1: 240.77 – 241.36 Mb Chr 1: 174.89 – 175.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene. ^{[5] [6]}

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling. ^[7]

Interactions

RGS7 has been shown to interact with:

• GNB5, ^{[8] [9]}
• GPR158, ^[10]
• GPR179, ^[10]
• PKD1, ^[11] and
• SNAPAP. ^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000182901 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026527 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi: 10.1016/S0092-8674(00)80998-8 . PMID   8548815. S2CID   7815240.
6. "Entrez Gene: RGS7 regulator of G-protein signalling 7".
7. Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics . 54 (1–3): 33–46. doi:10.1007/s12013-009-9052-9. PMC   2827338 . PMID   19521673.
8. Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi: 10.1073/pnas.96.5.2503 . PMC   26814 . PMID   10051672.
9. Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi: 10.1074/jbc.274.43.31087 . PMID   10521509.
10. Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC   3373406 . PMID   22689652.
11. Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi: 10.1073/pnas.96.11.6371 . PMC   26888 . PMID   10339594.
12. Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID   12659861.

Further reading

• Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". J. Neurochem. 70 (5): 1964–72. doi: 10.1046/j.1471-4159.1998.70051964.x . PMID   9572280.
• Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. Bibcode:1999PNAS...96.2503L. doi: 10.1073/pnas.96.5.2503 . PMC   26814 . PMID   10051672.
• Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi: 10.1074/jbc.274.14.9899 . PMID   10092682.
• Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. Bibcode:1999PNAS...96.6371K. doi: 10.1073/pnas.96.11.6371 . PMC   26888 . PMID   10339594.
• Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi: 10.1073/pnas.96.11.6489 . PMC   26909 . PMID   10339615.
• Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi: 10.1074/jbc.274.43.31087 . PMID   10521509.
• Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity". J. Biol. Chem. 275 (36): 28167–72. doi: 10.1074/jbc.M002905200 . PMID   10862767.
• Rose JJ, Taylor JB, Shi J, Cockett MI, Jones PG, Hepler JR (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms". J. Neurochem. 75 (5): 2103–12. doi: 10.1046/j.1471-4159.2000.0752103.x . PMID   11032900. S2CID   20156736.
• Zhang JH, Barr VA, Mo Y, Rojkova AM, Liu S, Simonds WF (2001). "Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain". J. Biol. Chem. 276 (13): 10284–9. doi: 10.1074/jbc.M009247200 . PMID   11152459.
• Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, Kim E (2002). "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha". J. Biol. Chem. 277 (36): 32954–62. doi: 10.1074/jbc.M200859200 . PMID   12077120.
• Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID   12659861.
• Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction". J. Biol. Chem. 278 (23): 21307–13. doi: 10.1074/jbc.M212884200 . PMID   12670932.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" (PDF). Mol. Cell. Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID   14718574. S2CID   7710900.
• Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMC   1405920 . PMID   15496508.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism". J. Biol. Chem. 281 (38): 28222–31. doi: 10.1074/jbc.M604428200 . PMID   16867977.