RINT1

RINT1
Identifiers
Aliases	RINT1 , RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089 MGI: 1916233 HomoloGene: 11070 GeneCards: RINT1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	105,567,677 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,025,367 bp
RNA expression pattern
	Top expressed in
	tibia; ; body of pancreas; ; gastrocnemius muscle; ; right uterine tube; ; Achilles tendon; ; skin of abdomen; ; cerebellar hemisphere; ; gastric mucosa; ; sural nerve; ; biceps brachii;
	Top expressed in
	spermatocyte; ; islet of Langerhans; ; fossa; ; esophagus; ; stomach; ; neural tube; ; yolk sac; ; spermatid; ; proximal tubule; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ; Dsl1/NZR complex ; endoplasmic reticulum membrane ; endoplasmic reticulum ; membrane ; cytosol ;
Biological process	protein transport ; cell cycle ; regulation of ER to Golgi vesicle-mediated transport ; Golgi vesicle transport ; vesicle-mediated transport ; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ; Golgi organization ;
	Sources:Amigo / QuickGO
Orthologs
	60561
	72772
	ENSG00000135249
	ENSMUSG00000028999
	Q6NUQ1
	Q8BZ36
	NM_021930 ; NM_001346599 ; NM_001346600 ; NM_001346601 ; NM_001346603 Contents Interactions ; References ; Further reading ;
	NM_177323 ; NM_001310467
	NP_001333528 ; NP_001333529 ; NP_001333530 ; NP_001333532 ; NP_068749
	NP_001297396 ; NP_796297
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.^[5]^[6]^[7]

Interactions

RINT1 has been shown to interact with Rad50 ^[5] and ZW10.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi: 10.1074/jbc.M008893200 . PMID 11096100.
1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410 . PMID 15029241.
↑ "Entrez Gene: RINT1 RAD50 interactor 1".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507 . PMID 15272311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792 . PMID 16571679.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. doi: 10.1016/j.molcel.2006.02.016 . PMID 16600870.
Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. doi:10.1128/MCB.02396-06. PMC 1951495 . PMID 17470549.
Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMC 1995728 . PMID 17699596.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11096100-5] 1 2 Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi: 10.1074/jbc.M008893200 . PMID 11096100.

[pmid15029241-6] 1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410 . PMID 15029241.

[entrez-7] "Entrez Gene: RINT1 RAD50 interactor 1".

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RINT1

Contents

Interactions

Related Research Articles

References

Further reading