Repulsive guidance molecule B

RGMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BQ6, 4BQ7, 4BQ8, 4UHZ, 4UI0, 4UI2
Identifiers
Aliases	RGMB , DRAGON, repulsive guidance molecule family member b, repulsive guidance molecule BMP co-receptor b
External IDs	OMIM: 612687; MGI: 1916049; HomoloGene: 65355; GeneCards: RGMB; OMA:RGMB - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q15 Start 98,768,650 bp [1] End 98,798,643 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 A2 Start 15,803,188 bp [2] End 15,831,039 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum pylorus skin of arm skin of thigh tibialis anterior muscle cardia cardiac muscle tissue of right atrium rectum deltoid muscle spinal ganglia Top expressed in Rostral migratory stream otolith organ utricle Paneth cell lateral habenular nucleus paraventricular nucleus of thalamus medial habenular nucleus spinal ganglia lumbar spinal ganglion sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity identical protein binding protein binding Cellular component membrane raft anchored component of membrane plasma membrane membrane endoplasmic reticulum-Golgi intermediate compartment anchored component of plasma membrane Biological process positive regulation of transcription, DNA-templated signal transduction BMP signaling pathway cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285704 68799 Ensembl ENSG00000174136 ENSMUSG00000048027 UniProt Q6NW40 Q7TQ33 RefSeq (mRNA) NM_001012761 NM_173670 NM_001366508 NM_001366509 NM_001366510 NM_001366511 NM_178615 RefSeq (protein) NP_001012779 NP_001353437 NP_001353438 NP_001353439 NP_001353440 NP_848730 Location (UCSC) Chr 5: 98.77 – 98.8 Mb Chr 17: 15.8 – 15.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. ^[5] In humans this protein is encoded by the RGMB gene. ^[6]

Function

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system. ^{[7] [8]}

There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. ^{[9] [10]} Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000174136 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048027 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Corradini, Elena; Babitt, Jodie L.; Lin, Herbert Y. (October 2009). "The RGM/DRAGON family of BMP co-receptors". Cytokine & Growth Factor Reviews. 20 (5–6): 389–398. doi:10.1016/j.cytogfr.2009.10.008. PMC   3715994 . PMID   19897400.
6. "Entrez Gene: RGM domain family".
7. Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ (April 2005). "DRAGON, a bone morphogenetic protein co-receptor". J. Biol. Chem. 280 (14): 14122–9. doi: 10.1074/jbc.M410034200 . PMID   15671031.
8. Severyn CJ, Shinde U, Rotwein P (September 2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". Biochem. J. 422 (3): 393–403. doi:10.1042/BJ20090978. PMC   4242795 . PMID   19698085.
9. Li J, Ye L, Sanders AJ, Jiang WG (March 2012). "Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling". J Cell Biochem. 113 (7): 2523–31. doi:10.1002/jcb.24128. PMID   22415859. S2CID   35629616.
10. Li J, Ye L, Kynaston HG, Jiang WG (February 2012). "Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells". Int. J. Oncol. 40 (2): 544–50. doi: 10.3892/ijo.2011.1251 . PMID   22076499.
11. Li J, Ye L, Mansel RE, Jiang WG (May 2011). "Potential prognostic value of repulsive guidance molecules in breast cancer". Anticancer Res. 31 (5): 1703–11. PMID   21617229.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Samad TA, Srinivasan A, Karchewski LA, et al. (2004). "DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties". J. Neurosci. 24 (8): 2027–36. doi:10.1523/JNEUROSCI.4115-03.2004. PMC   6730385 . PMID   14985445.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.