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Idarubicin or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. Similar to other anthracyclines, it also induces histone eviction from chromatin.
Keratomalacia is an eye disorder that results from vitamin A deficiency. Vitamin A is required to maintain specialized epithelia.
Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. The heart becomes weaker and is not as efficient in pumping blood. Cardiotoxicity may be caused by chemotherapy treatment and/or radiotherapy; complications from anorexia nervosa; adverse effects of heavy metals intake; the long-term abuse of or ingestion at high doses of certain strong stimulants such as cocaine; or an incorrectly administered drug such as bupivacaine.
The central canal is the cerebrospinal fluid-filled space that runs through the spinal cord. The central canal lies below and is connected to the ventricular system of the brain, from which it receives cerebrospinal fluid, and shares the same ependymal lining. The central canal helps to transport nutrients to the spinal cord as well as protect it by cushioning the impact of a force when the spine is affected.
A pulmonary-to-systemic shunt is a cardiac shunt which allows, or is designed to cause, blood to flow from the pulmonary circulation to the systemic circulation. This occurs when:
- there is a passage between two or more of the great vessels; and,
- pulmonic pressure is higher than systemic pressure and/or the shunt has a one-way valvular opening.
The incisive canals are two bony canals of the anterior hard palate connecting the nasal cavity and the oral cavity. An incisive canal courses through each maxilla. Below, the two incisive canals typically converge medially.
Gynecological surgery refers to surgery on the female reproductive system usually performed by gynecologists. It includes procedures for benign conditions, cancer, infertility, and incontinence. Gynecological surgery may occasionally be performed for optional or cosmetic purposes, such as hymenoplasty or labiaplasty.
The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. The lingual septum is closely associated with the hyoglossus membrane, allowing the binding of the tongue to the hyoid muscles.
A nerve fascicle, is a bundle of nerve fibers belonging to a nerve in the peripheral nervous system. A nerve fascicle is also called a fasciculus, as is a nerve tract in the central nervous system.
The incisive papilla is an oval midline mucosal prominence of the anterior hard palate overlying the incisive fossa. It is situated posteriorly to the central incisors, and represents the anterior extremity of the palatine raphe.
Diascopy is a test for blanchability performed by applying pressure with a finger or glass slide and observing color changes.
Curel is a commune in the Alpes-de-Haute-Provence department in southeastern France.
U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive effects, and reverses the memory impairment produced by anticholinergic drugs. U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds. This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.
Chondrodermatitis nodularis chronica helicis is a small, nodular, tender, chronic inflammatory lesion occurring on the helix of the ear, most often in men. it often presents as a benign painful erythematous nodule fixed to the cartilage of the helix or antihelix of the external ear. Although the exact cause of the condition is unknown, it has been linked to head pressure on the ear while sleeping. Treatment options include the use of pressure-relieving devices or, in cases where that is not an option, surgery.
Nasolacrimal duct cysts are a cutaneous condition that is a developmental defect present at birth.
Mouth and genital ulcers with inflamed cartilage syndrome is a cutaneous condition with features of both Behçet's disease and relapsing polychondritis. Recently, it has been questioned whether these two conditions are linked in the same individual or are two separate disorders.
A limbus vertebra is a bone tubercle formed by bone trauma on a vertebral body, bearing a radiographic similarity to a vertebral fracture. The anterior-superior corner of a single vertebra is the common site for this defect although it can also be seen at the inferior corner as well as the posterior or anterior margin. Anatomically, it is assumed to be an intra-vertebral body herniation of the disc material occurring during adolescent growth spurt when the ring apophysis has not yet fused. It was first described by Schmorl in 1927 and later in detail by Leif Sward and Adad Baranto.
The N-localizer is a device that enables guidance of stereotactic surgery or radiosurgery using tomographic images that are obtained via computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET). The N-localizer comprises a diagonal rod that spans two vertical rods to form an N-shape and permits calculation of the point where a tomographic image plane intersects the diagonal rod. Attaching three N-localizers to a stereotactic instrument allows calculation of three points where a tomographic image plane intersects three diagonal rods. These points determine the spatial orientation of the tomographic image plane relative to the stereotactic frame.
Rhytidhysteron is a genus of fungi in the family Patellariaceae. It has 21 species.
ENA-001 is a drug related to almitrine which acts as a respiratory stimulant, with its mechanism of action primarily thought to involve blocking the BKCa potassium channel, although secondary mechanisms may also be involved. It was developed by Galleon Pharmaceuticals, and is being tested in clinical trials for potential uses in post-operative care, as well as more generally to counteract the respiratory depression which can be a side effect of opioid analgesic drugs.
References
- ↑ Mudhigeti, Nagaraja; Patnayak, Rashmi; Kalawat, Usha; Yeddula, Spoorthy Rekha C (2018). "Subcutaneous Rhytidhysteron Infection: A Case Report from South India with Literature Review". Cureus. 10 (4): e2406. doi: 10.7759/cureus.2406 . ISSN 2168-8184. PMC 5984264 . PMID 29872587.
