Robert M. Graham (cardiologist)

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Robert M. Graham
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Robert M Graham
Born1948
NationalityAustralian, American
Alma mater University of New South Wales
Occupation(s) Cardiologist
Scientist
Known forContributions to adrenergic receptor structure, function and signalling
AwardsForeign Member, Royal Danish Academy of Sciences and Letters (2010)
Scientific career
FieldsMolecular Cardiology
Molecular Pharmacology
Institutions Victor Chang Cardiac Research Institute
University of New South Wales
University of Texas Southwestern Medical School
Harvard Medical School
Cleveland Clinic Foundation
Thesis Molecular characterization of the α1-adrenergic receptor  (1988)
Website Professor Bob Graham

Robert Michael Graham (born 1948) is an Australian-born clinician-scientist. He is the Des Renford Professor of Medicine at University of New South Wales [1] and the Head of the Molecular Cardiology and Biophysics Division at Victor Chang Cardiac Research Institute. [2]

Contents

Education

Robert Graham received his medical training, MBBS with Honours, and his MD degree from the University of New South Wales. He then trained as a physician in internal medicine and cardiorenal disease in Australia and the US, leading to Fellowships of the Royal Australian College of Physicians and the American College of Physicians.[ citation needed ]

In the US he received postdoctoral training in pharmacology (Alfred G. Gilman, Chairman and Nobel Laureate) and medicine (Don Seldin, Chairman) at the University of Texas Southwestern Medical School. Graham was then appointed as an Assistant Professor in Pharmacology and Medicine at University of Texas Southwestern Medical School. [3]

Career

In 1982, Graham moved to the Massachusetts General Hospital (Cellular and Molecular Research Laboratory, Edgar Haber, Chairman) and Harvard Medical School, Boston as an Associate Professor of Medicine. During his time in Boston, he did a sabbatical in the laboratory of Nobel Laureate H. Gobind Khorana at the Massachusetts Institute of Technology. In 1989, he moved to the Cleveland Clinic Foundation as the Robert C. Tarazi Chairman of the Molecular Cardiology Department, and Professor of Physiology and Biophysics at Case Western Reserve University School of Medicine, Cleveland, Ohio. [3]

Graham returned to Australia in 1994 as the inaugural Executive Director at the Victor Chang Cardiac Research Institute. [4] He held the position until stepping down in March 2020. [5]

Research

Graham's research is reported in over 290 peer-reviewed papers [6] and cited over 26,000 times. [7]

For many years his research has focused on molecular cardiology, with emphasis on circulatory control mechanisms, receptor signalling, hypertension and cardiac hypertrophy. Together with Charles Homcy, his work contributed to understanding receptor structure, function and signalling. This work subsequently led to the discovery that a protein crosslinking enzyme also functions as a unique multifunctional protein involved in receptor signalling. [8] [9]

More recently, together with colleagues, Ahsan Husain and Siiri Iismaa, Graham has been actively involved in studies of cardiac regeneration and the application of stem cells for the treatment of heart diseases, and with A/Prof Eleni Giannoulatou, the pathophysiology and genetics of spontaneous coronary artery dissection. [10]

In 2021, with Glenn King and Nathan Palpant, he co-founded Infensa Bioscience, an Australian biotechnology company. [11]

He serves on the Board of Directors of the Lowy Medical Research Institute [12] [13] in California; and Infensa Bioscience, [14] an Australian biotechnology company, and also as the Chairman of its Clinical Advisory Board. He also serves as Chairman, Strategic Advisory Board, Institute of Molecular Biosciences at the University of Queensland [15] and as Vice-President and Secretary, Biological Sciences, Australian Academy of Science. [16]

Awards and recognition

Personal life

Graham has four children, Dana Cadden, Simon Graham, Caitlin Graham and Shaun Graham, and one sister, Monica Graham. He was married to Jennifer Graham (nee Hilsdon).

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Daniel P. Kelly is Director of the Penn[1][2] and CHOP[3][4] Cardiovascular Institutes (CVI) and the Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases at the University of Pennsylvania Perelman School of Medicine and the Rachel Ash Presidential Professor at Children’s Hospital of Philadelphia (CHOP). He is a cardiologist and physician-scientist recognized for his contributions to the transcriptional control of mitochondrial function and the metabolic origins of heart disease.

References

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  4. "How billionaires, surgeons and royals built the Victor Chang institute". Australian Financial Review. 2019-11-15. Retrieved 2021-09-09.
  5. Professor Bob Graham steps down after 25 years at Victor Chang Cardiac Research Institute, Australian Broadcasting Corporation, 2019-11-19, retrieved 2021-09-09
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  8. Nakaoka, H.; Perez, D. M.; Baek, K. J.; Das, T.; Husain, A.; Misono, K.; Im, M. J.; Graham, R. M. (1994-06-10). "Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function". Science. 264 (5165): 1593–1596. doi:10.1126/science.7911253. ISSN   0036-8075. PMID   7911253.
  9. Lorand, Laszlo; Graham, Robert M. (February 2003). "Transglutaminases: crosslinking enzymes with pleiotropic functions". Nature Reviews. Molecular Cell Biology. 4 (2): 140–156. doi:10.1038/nrm1014. ISSN   1471-0072. PMID   12563291. S2CID   19353789.
  10. Iismaa, Siiri E.; Hesselson, Stephanie; McGrath-Cadell, Lucy; Muller, David W.; Fatkin, Diane; Giannoulatou, Eleni; Kovacic, Jason; Graham, Robert M. (2021-01-01). "Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women". Heart, Lung and Circulation. 30 (1): 27–35. doi:10.1016/j.hlc.2020.05.110. ISSN   1443-9506. PMC   7710561 . PMID   32713767.
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