Robert M. Graham | |
---|---|
Born | 1948 |
Nationality | Australian, American |
Alma mater | University of New South Wales |
Occupation(s) | Cardiologist Scientist |
Known for | Contributions to adrenergic receptor structure, function and signalling |
Awards | Foreign Member, Royal Danish Academy of Sciences and Letters (2010) |
Scientific career | |
Fields | Molecular Cardiology Molecular Pharmacology |
Institutions | Victor Chang Cardiac Research Institute University of New South Wales University of Texas Southwestern Medical School Harvard Medical School Cleveland Clinic Foundation |
Thesis | Molecular characterization of the α1-adrenergic receptor (1988) |
Website | Professor Bob Graham |
Robert Michael Graham (born 1948) is an Australian-born clinician-scientist. He is the Des Renford Professor of Medicine at University of New South Wales [1] and the Head of the Molecular Cardiology and Biophysics Division at Victor Chang Cardiac Research Institute. [2]
Robert Graham received his medical training, MBBS with Honours, and his MD degree from the University of New South Wales. He then trained as a physician in internal medicine and cardiorenal disease in Australia and the US, leading to Fellowships of the Royal Australian College of Physicians and the American College of Physicians.[ citation needed ]
In the US he received postdoctoral training in pharmacology (Alfred G. Gilman, Chairman and Nobel Laureate) and medicine (Don Seldin, Chairman) at the University of Texas Southwestern Medical School. Graham was then appointed as an Assistant Professor in Pharmacology and Medicine at University of Texas Southwestern Medical School. [3]
In 1982, Graham moved to the Massachusetts General Hospital (Cellular and Molecular Research Laboratory, Edgar Haber, Chairman) and Harvard Medical School, Boston as an Associate Professor of Medicine. During his time in Boston, he did a sabbatical in the laboratory of Nobel Laureate H. Gobind Khorana at the Massachusetts Institute of Technology. In 1989, he moved to the Cleveland Clinic Foundation as the Robert C. Tarazi Chairman of the Molecular Cardiology Department, and Professor of Physiology and Biophysics at Case Western Reserve University School of Medicine, Cleveland, Ohio. [3]
Graham returned to Australia in 1994 as the inaugural Executive Director at the Victor Chang Cardiac Research Institute. [4] He held the position until stepping down in March 2020. [5]
Graham's research is reported in over 290 peer-reviewed papers [6] and cited over 26,000 times. [7]
For many years his research has focused on molecular cardiology, with emphasis on circulatory control mechanisms, receptor signalling, hypertension and cardiac hypertrophy. Together with Charles Homcy, his work contributed to understanding receptor structure, function and signalling. This work subsequently led to the discovery that a protein crosslinking enzyme also functions as a unique multifunctional protein involved in receptor signalling. [8] [9]
More recently, together with colleagues, Ahsan Husain and Siiri Iismaa, Graham has been actively involved in studies of cardiac regeneration and the application of stem cells for the treatment of heart diseases, and with A/Prof Eleni Giannoulatou, the pathophysiology and genetics of spontaneous coronary artery dissection. [10]
In 2021, with Glenn King and Nathan Palpant, he co-founded Infensa Bioscience, an Australian biotechnology company. [11]
He serves on the Board of Directors of the Lowy Medical Research Institute [12] [13] in California; and Infensa Bioscience, [14] an Australian biotechnology company, and also as the Chairman of its Clinical Advisory Board. He also serves as Chairman, Strategic Advisory Board, Institute of Molecular Biosciences at the University of Queensland [15] and as Vice-President and Secretary, Biological Sciences, Australian Academy of Science. [16]
Graham has four children, Dana Cadden, Simon Graham, Caitlin Graham and Shaun Graham, and one sister, Monica Graham. He was married to Jennifer Graham (nee Hilsdon).
Victor Peter Chang was a Chinese-born Australian cardiac surgeon and a pioneer of modern heart transplantation in Australia.
The Victor Chang Cardiac Research Institute (VCCRI) is an Australian non-profit medical research facility that is dedicated to finding cures for cardiovascular disease. With headquarters located in Darlinghurst, New South Wales, the research hub is home to more than 20 research laboratories and the Victor Chang Cardiac Research Institute Innovation Centre. The institute's mission is "the relief of pain and suffering, and the promotion of well-being, through an understanding of the fundamental mechanisms of cardiovascular disease". Its key research is focused on the prevention and treatment of various heart diseases, including arrhythmia, cardiac arrest, cardiomyopathy, congenital heart disease, heart attack, heart failure, high cholesterol, obesity, spontaneous coronary artery dissection (SCAD) and stroke.
Abdul Jamil Tajik is a Pakistani American physician and medical investigator in the field of cardiovascular diseases. He is listed by the Institute for Scientific Information as a highly cited researcher – one of the top 250 researchers in his field in terms of number of citations.
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Stefanie Dimmeler is a German biologist specializing in the pathophysiological processes underlying cardiovascular diseases. Her awards and honours include the Gottfried Wilhelm Leibniz Prize of the German Research Foundation for her work on the programmed cell death of endothelial cells. Since 2008 she has led the Institute for Cardiovascular Regeneration at the University of Frankfurt. Her current work is focusing to develop cellular and pharmacological strategies to improve cardiovascular repair and regeneration. Her work aims to establish non-coding RNAs as novel therapeutic targets.
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Walter J. “Wally” Koch is an American scientist best known for his work with G protein-coupled receptors in the heart and gene therapy approaches to cardiovascular disease. He is currently an Instructor at Duke University, and formerly at Lewis Katz School of Medicine at Temple University where he was the Director of the Center for Translational Medicine, Professor and Chairman of the Department of Pharmacology, and W.W. Smith Chair in Cardiovascular Medicine. In 2013, he co-founded the biotech company, Renovacor.
Ashok Seth is an Indian interventional cardiologist, credited with the performance of over 50,000 angiograms and 20,000 angioplasties, which has been included in the Limca Book of Records, a book for achievements and records from an Indian perspective. He is a Fellow of the Royal Colleges of Physicians of London, Edinburgh and Ireland and serves as the chief cardiologist, holding the chairs of the department of cardiovascular sciences and cardiology council at the Fortis Healthcare. Seth, a recipient of the Order of Isabella the Catholic, was honored by the Government of India with the fourth highest Indian civilian award of Padma Shri, in 2003, followed by Padma Bhushan, the third highest Indian civilian award, in 2015.
Nagarur Gopinath was an Indian surgeon and one of the pioneers of cardiothoracic surgery in India. He is credited with the first successful performance of open heart surgery in India which he performed in 1962. He served as the honorary surgeon to two Presidents of India and was a recipient of the fourth highest Indian civilian award of Padma Shri in 1974 and Dr. B. C. Roy Award, the highest Indian medical award in 1978 from the Government of India.
Charles Antzelevitch is an American cardiovascular research scientist in the fields of cardiac electrophysiology and cardiac arrhythmia syndromes.
Richard Paul Harvey is a molecular biologist, the Sir Peter Finley professor of Heart Research at the University of New South Wales and Deputy Director and Head of the Developmental and Stem Cell Biology Division at the Victor Chang Cardiac Research Institute.
Kewal Kishan Talwar is an Indian cardiologist, medical academic and writer, and a former chairman of the Medical Council of India. He is a former director of the Post Graduate Institute of Medical Education and Research (PGIMER) and is reported to have performed the first implantation of Implantable cardioverter-defibrillator (ICD) therapy in South Asia. He is also credited with the introduction of Cardiac Resynchronization Therapy in India. He is a recipient of several honours including B. C. Roy Award, the highest Indian award in the medical category. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 2006, for his contributions to medicine. Presently Dr. Talwar is working in PSRI Hospital Sheikh Sarai, New Delhi as the chairman of Cardiac Sciences
Kenneth R. Chien is an American doctor and medical scientist who has been a research director at Karolinska Institute, in Stockholm, since 2013. Chien has several papers with over 1,000 citations and a h-index of 132. His area of expertise is cardiovascular science. His research into regenerative cardiovascular medicine, specifically while director of the Cardiovascular Program of the Harvard Stem Cell Institute, led to his co-founding, in 2010, of ModeRNA Therapeutics. In 2018, the company re-branded as Moderna, Inc. Chien is a recipient of the Walter Bradford Cannon Award of the American Physiology Society and the Pasarow Award. He is a member of the Norwegian Academy of Science and Letters, the Austrian Academy of Sciences, and has received an honorary doctorate from the University of Edinburgh.
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Günter Breithardt is a German physician, cardiologist and emeritus university professor. He is known for his research in the field of rhythmology, especially the diagnosis and pharmacological and non-pharmacological therapy of cardiac arrhythmias and acute cardiac death, in particular the identification of arrhythmia-triggering gene mutations. For 21 years he headed the Medical Clinic and Polyclinic C at Münster University Hospital. A number of his academic students hold university management and chief physician positions.
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