SF3B3

SF3B3
Identifiers
Aliases	SF3B3 , RSE1, SAP130, SF3b130, STAF130, splicing factor 3b subunit 3
External IDs	OMIM: 605592 MGI: 1289341 HomoloGene: 6579 GeneCards: SF3B3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,577,670 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,573,419 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; stromal cell of endometrium; ; skin of abdomen; ; canal of the cervix; ; right lobe of thyroid gland; ; right uterine tube; ; tibial nerve; ; minor salivary gland; ; left lobe of thyroid gland; ; left uterine tube;
	Top expressed in
	maxillary prominence; ; somite; ; primitive streak; ; endocardial cushion; ; dermis; ; abdominal wall; ; thymus; ; ovary; ; hand; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; RNA binding ; nucleic acid binding ; protein-containing complex binding ;
Cellular component	catalytic step 2 spliceosome ; spliceosomal complex ; U12-type spliceosomal complex ; nucleolus ; small nuclear ribonucleoprotein complex ; nucleus ; nucleoplasm ; U2-type precatalytic spliceosome ;
Biological process	RNA splicing, via transesterification reactions ; mRNA splicing, via spliceosome ; mRNA processing ; RNA splicing ; negative regulation of protein catabolic process ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	23450
	101943
	ENSG00000189091
	ENSMUSG00000033732
	Q15393
	Q921M3
	NM_012426
	NM_133953
	NP_036558
	NP_598714
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.^[5]^[6]

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.^[6]

Interactions

SF3B3 has been shown to interact with SF3B1,^[5]^[7] Transcription initiation protein SPT3 homolog ^[8] and TAF9.^[8]

Related Research Articles

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

Pinin is a protein that in humans is encoded by the PNN gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.

Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000189091 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033732 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155". Mol Cell Biol. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676 . PMID 10490618.
1 2 "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa".
↑ Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279 . PMID 12234937.
1 2 Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856 . PMID 11564863.

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID 7584028.
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Mintz PJ, Patterson SD, Neuwald AF, et al. (1999). "Purification and biochemical characterization of interchromatin granule clusters". EMBO J. 18 (15): 4308–20. doi:10.1093/emboj/18.15.4308. PMC 1171507 . PMID 10428969.
Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203 . PMID 11406595.
Gangloff YG, Pointud JC, Thuault S, et al. (2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol. Cell. Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236 . PMID 11438666.
Will CL, Schneider C, MacMillan AM, et al. (2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMC 125580 . PMID 11500380.
Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856 . PMID 11564863.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266 . PMID 11991638.
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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000189091 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033732 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10490618-5] 1 2 Das BK; Xia L; Palandjian L; Gozani O; Chyung Y; Reed R (February 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155". Mol Cell Biol. 19 (10): 6796–802. doi:10.1128/mcb.19.10.6796. PMC 84676 . PMID 10490618.

[entrez-6] 1 2 "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa".

[pmid12234937-7] Will, Cindy L; Urlaub Henning; Achsel Tilmann; Gentzel Marc; Wilm Matthias; Lührmann Reinhard (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279 . PMID 12234937.

[pmid11564863-8] 1 2 Martinez, E; Palhan V B; Tjernberg A; Lymar E S; Gamper A M; Kundu T K; Chait B T; Roeder R G (October 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856 . PMID 11564863.

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SF3B3

Contents

Interactions

Related Research Articles

References

Further reading