Transcription initiation protein SPT3 homolog

Last updated
SUPT3H
Identifiers
Aliases SUPT3H , SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDs OMIM: 602947 MGI: 1923723 HomoloGene: 121570 GeneCards: SUPT3H
Orthologs
SpeciesHumanMouse
Entrez

8464

109115

Ensembl

ENSG00000196284

ENSMUSG00000038954

UniProt

O75486

n/a

RefSeq (mRNA)

NM_178652
NM_001357320

RefSeq (protein)

n/a

Location (UCSC) Chr 6: 44.81 – 45.38 Mb Chr 17: 45.09 – 45.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene. [5] [6] [7]

Contents

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2, [8] [9] TAF6L, [9] TADA3L, [9] TAF5L, [9] SF3B3, [9] SUPT7L, [9] Myc, [10] TAF9, [9] Transformation/transcription domain-associated protein, [9] TAF12, [9] TAF10, [8] [9] TAF4 [8] and DDB1. [9]

Related Research Articles

<span class="mw-page-title-main">TATA-binding protein</span> Protein-coding gene in the species Homo sapiens

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

<span class="mw-page-title-main">PCAF</span> Protein-coding gene in the species Homo sapiens

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

<span class="mw-page-title-main">TAF6</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.

<span class="mw-page-title-main">Transformation/transcription domain-associated protein</span> Protein-coding gene in the species Homo sapiens

Transformation/transcription domain-associated protein, also known as TRRAP, is a protein that in humans is encoded by the TRRAP gene. TRRAP belongs to the phosphatidylinositol 3-kinase-related kinase protein family.

<span class="mw-page-title-main">KAT2A</span> Protein-coding gene in the species Homo sapiens

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

<span class="mw-page-title-main">DDB1</span> Protein-coding gene in the species Homo sapiens

DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.

<span class="mw-page-title-main">TAF9</span> Protein-coding gene in the species Homo sapiens

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.

<span class="mw-page-title-main">TAF12</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

<span class="mw-page-title-main">TAF4</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

<span class="mw-page-title-main">TAF2</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

<span class="mw-page-title-main">TAF10</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

<span class="mw-page-title-main">TAF5</span> Protein-coding gene in the species Homo sapiens

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

<span class="mw-page-title-main">TADA3L</span> Protein-coding gene in the species Homo sapiens

Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene. Cytogenetic location: 3p25.3

<span class="mw-page-title-main">SF3B3</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

<span class="mw-page-title-main">TADA2L</span> Protein-coding gene in the species Homo sapiens

Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.

<span class="mw-page-title-main">TAF5L</span> Protein-coding gene in the species Homo sapiens

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L is an enzyme that in humans is encoded by the TAF5L gene.

<span class="mw-page-title-main">TAF6L</span> Protein-coding gene in the species Homo sapiens

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.

<span class="mw-page-title-main">SUPT7L</span> Protein-coding gene in the species Homo sapiens

STAGA complex 65 subunit gamma is a protein that in humans is encoded by the SUPT7L gene.

<span class="mw-page-title-main">TBP-associated factor</span> Protein domains

The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a part of the transcription initiation factor TFIID multimeric protein complex. It also makes up many other factors, including SL1. They mediate the formation of the transcription preinitiation complex, a step preceding transcription of DNA to RNA by RNA polymerase II.

<span class="mw-page-title-main">POLE4</span> Protein-coding gene in the species Homo sapiens

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196284 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038954 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi: 10.1016/S0092-8674(00)81219-2 . PMID   9674425. S2CID   18942972.
  6. ↑ Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi: 10.1074/jbc.273.37.23781 . PMID   9726987.
  7. ↑ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
  8. 1 2 3 Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC   150203 . PMID   11406595.
  9. 1 2 3 4 5 6 7 8 9 10 11 Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC   99856 . PMID   11564863.
  10. ↑ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi: 10.1074/jbc.M211795200 . PMC   4031917 . PMID   12660246.

Further reading

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